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CARDAMONIN

Product Name
CARDAMONIN
CAS No.
19309-14-9
Chemical Name
CARDAMONIN
Synonyms
(8CI);Cardamonin;Cardamomin-RM;CARDAMONIN(RG);(E)-Cardamonin;Cardamonin, >=98%;Alpinetin chalcone;6-Diaminocaproic acid;CAS19309-14-9 CARDAMONIN;(E)-Cardamonin ((E)-Cardamomin)
CBNumber
CB31092214
Molecular Formula
C16H14O4
Formula Weight
270.28
MOL File
19309-14-9.mol
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CARDAMONIN Property

Melting point:
199~200℃
Boiling point:
484.5±45.0 °C(Predicted)
Density 
1.282±0.06 g/cm3(Predicted)
storage temp. 
room temp
solubility 
DMSO: ≥20mg/mL
form 
powder
pka
7.00±0.40(Predicted)
color 
yellow
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 weeks.
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Safety

Hazard Codes 
N
Risk Statements 
50/53
Safety Statements 
61-24/25
RIDADR 
UN 3077 9 / PGIII
HS Code 
29242990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C8249
Product name
Cardamonin
Purity
≥98% (HPLC)
Packaging
5mg
Price
$168
Updated
2024/03/01
Sigma-Aldrich
Product number
681672
Product name
Wnt/β-catenin Inhibitor, Cardamonin
Packaging
2mg
Price
$172
Updated
2024/03/01
Cayman Chemical
Product number
18310
Product name
Cardamonin
Purity
≥98%
Packaging
5mg
Price
$59
Updated
2024/03/01
Cayman Chemical
Product number
18310
Product name
Cardamonin
Purity
≥98%
Packaging
10mg
Price
$112
Updated
2024/03/01
Sigma-Aldrich
Product number
PHL80379
Product name
Cardamomin
Purity
phyproof Reference Substance
Packaging
10mg
Price
$400
Updated
2024/03/01
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CARDAMONIN Chemical Properties,Usage,Production

Description

Cardamonin (19309-14-9) inhibits NF-κB activation via inhibition of IκBα degradation and phosphorylation, IκB kinase activation and NF-κB nuclear translocation.1,2 Cardamonin displays anti-inflammatory activity in various models.3?Cell permeable.

Uses

Cardamonin has been used as a glycogen synthase kinase 3 (GSK3) inhibitor to study its effects on β-catenin loss and gain-of-function in human preimplantation embryos.

Definition

ChEBI: Cardamonin is a member of chalcones.

General Description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Biological Activity

Chalone analog that display anti-inflammatory activity. Inhibits NO and PGE 2 production from LPS- and IFN- γ -induced RAW cells and inhibits TXB 2 production via the COX-1 and COX-2 pathways. Inhibits NF- κ B activation via inhibition of I κ B α degradation and phosphorylation, I κ B kinase activation and NF- κ B nuclear translocation.

Biochem/physiol Actions

Cardamonin is a calchone from Aplinia species (zingiberaceous plant species). Cardamonin inhibits pigmentation in melanocytes through suppression of Wnt/b-catenin signaling pathway. Cardamonin suppressed Wnt/b-catenin signaling by a mechanism involving proteasome-mediated degradation of b-catenin (GSK-3b-independent pathway). Research has shown that Cardamonin possesses anti-inflammatory activity via suppression of NF-kB nuclear translocation and Ik-Ba phosphorylation.

storage

Store at +4°C

References

1) Lee?et al. (2006),?Blockade of nuclear factor-kappaB signaling pathway and anti-inflammatory activity of cardamonin, a chalcone analog from Alpinia conchigera; J. Pharmacol. Exp. Ther.,?316?271 2) Israf?et al. (2007),?Cardamonin inhibits COX and iNOS expression via inhibition of p65NF-kappaB nuclear translocation and Ikappa-B phosphorylation in RAW 264.7 macrophage cells; Mol. Immunol.,?44?673 3) Ahmad?et al. (2006),?Cardamonin, inhibits pro-inflammatory mediators in activated RAW 264.7 cells and whole blood; Eur. Pharmacol. Exp. Ther., 538?188

CARDAMONIN Preparation Products And Raw materials

Raw materials

Preparation Products

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CARDAMONIN Suppliers

A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
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View Lastest Price from CARDAMONIN manufacturers

Shanghai Standard Technology Co., Ltd.
Product
Cardamonin 19309-14-9
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2019-10-23
Shanghai Standard Technology Co., Ltd.
Product
Cardamonin 19309-14-9
Price
US $0.00/mg
Min. Order
5mg
Purity
Analytical Standard
Supply Ability
10 g
Release date
2019-10-24
Career Henan Chemical Co
Product
CARDAMONIN 19309-14-9
Price
US $1.00/KG
Min. Order
1g
Purity
99%
Supply Ability
100KG
Release date
2018-12-24

19309-14-9, CARDAMONINRelated Search:


  • Alpinetin chalcone
  • Chalcone, 2', 4'-dihydroxy-6'-methoxy-
  • (E)-2',4'-Dihydroxy-6'-methoxychalcone
  • (E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-phenylprop-2-en-1-one
  • Cardamonin
  • (E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-phenyl-2-propen-1-one
  • 2-Propen-1-one, 1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenyl-, (2E)-
  • CARDAMONIN(RG)
  • (2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-phenyl-2-propen-1-one
  • Cardamonin (E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-phenylprop-2-en-1-one
  • (8CI)
  • Cardamonin, >=98%
  • Wnt/β-catenin Inhibitor, Cardamonin
  • Cardamonin, 98%, from Alpinia katsumadai Hayata
  • Wnt/β-catenin Inhibitor, Cardamonin - CAS 19309-14-9 - Calbiochem
  • (E)-Cardamonin
  • CAS19309-14-9 CARDAMONIN
  • 6-Diaminocaproic acid
  • (E)-Cardamonin ((E)-Cardamomin)
  • Cardamonin, from Alpinia katsumadai Hayata
  • Cardamomin-RM
  • 19309-14-9
  • 1939-14-9
  • Inhibitors
  • Chalcones