CARDAMONIN

ChemicalBook > CAS DataBase List > CARDAMONIN

Product Name: CARDAMONIN
CAS No.: 19309-14-9
Chemical Name: CARDAMONIN
Synonyms: (8CI);Cardamonin;CARDAMONIN(RG);(E)-Cardamonin;Cardamonin, >=98%;Alpinetin chalcone;6-Diaminocaproic acid;CAS19309-14-9 CARDAMONIN;(E)-Cardamonin ((E)-Cardamomin);Wnt/β-catenin Inhibitor, Cardamonin
CBNumber: CB31092214
Molecular Formula: C16H14O4
Formula Weight: 270.28
MOL File: 19309-14-9.mol

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CARDAMONIN Property

Melting point:: 199～200℃
Boiling point:: 484.5±45.0 °C(Predicted)
Density: 1.282±0.06 g/cm3(Predicted)
storage temp.: room temp
solubility: DMSO: ≥20mg/mL
form: powder
pka: 7.00±0.40(Predicted)
color: yellow
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 weeks.

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Safety

Hazard Codes: N
Risk Statements: 50/53
Safety Statements: 61-24/25
RIDADR: UN 3077 9 / PGIII
HS Code: 29242990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C8249
Product name: Cardamonin
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $168
Updated: 2024/03/01

Sigma-Aldrich

Product number: 681672
Product name: Wnt/β-catenin Inhibitor, Cardamonin
Packaging: 2mg
Price: $172
Updated: 2024/03/01

Cayman Chemical

Product number: 18310
Product name: Cardamonin
Purity: ≥98%
Packaging: 5mg
Price: $59
Updated: 2024/03/01

Cayman Chemical

Product number: 18310
Product name: Cardamonin
Purity: ≥98%
Packaging: 10mg
Price: $112
Updated: 2024/03/01

Sigma-Aldrich

Product number: PHL80379
Product name: Cardamomin
Purity: phyproof Reference Substance
Packaging: 10mg
Price: $400
Updated: 2024/03/01

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CARDAMONIN Chemical Properties,Usage,Production

Description

Cardamonin (19309-14-9) inhibits NF-κB activation via inhibition of IκBα degradation and phosphorylation, IκB kinase activation and NF-κB nuclear translocation.1,2 Cardamonin displays anti-inflammatory activity in various models.3?Cell permeable.

Uses

Cardamonin has been used as a glycogen synthase kinase 3 (GSK3) inhibitor to study its effects on β-catenin loss and gain-of-function in human preimplantation embryos.

Definition

ChEBI: Cardamonin is a member of chalcones.

General Description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Biological Activity

Chalone analog that display anti-inflammatory activity. Inhibits NO and PGE 2 production from LPS- and IFN- γ -induced RAW cells and inhibits TXB 2 production via the COX-1 and COX-2 pathways. Inhibits NF- κ B activation via inhibition of I κ B α degradation and phosphorylation, I κ B kinase activation and NF- κ B nuclear translocation.

Biochem/physiol Actions

Cardamonin is a calchone from Aplinia species (zingiberaceous plant species). Cardamonin inhibits pigmentation in melanocytes through suppression of Wnt/b-catenin signaling pathway. Cardamonin suppressed Wnt/b-catenin signaling by a mechanism involving proteasome-mediated degradation of b-catenin (GSK-3b-independent pathway). Research has shown that Cardamonin possesses anti-inflammatory activity via suppression of NF-kB nuclear translocation and Ik-Ba phosphorylation.

storage

Store at +4°C

References

1) Lee?et al. (2006),?Blockade of nuclear factor-kappaB signaling pathway and anti-inflammatory activity of cardamonin, a chalcone analog from Alpinia conchigera; J. Pharmacol. Exp. Ther.,?316?271 2) Israf?et al. (2007),?Cardamonin inhibits COX and iNOS expression via inhibition of p65NF-kappaB nuclear translocation and Ikappa-B phosphorylation in RAW 264.7 macrophage cells; Mol. Immunol.,?44?673 3) Ahmad?et al. (2006),?Cardamonin, inhibits pro-inflammatory mediators in activated RAW 264.7 cells and whole blood; Eur. Pharmacol. Exp. Ther., 538?188

CARDAMONIN Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from CARDAMONIN manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Cardamonin 19309-14-9
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2019-10-23

Shanghai Standard Technology Co., Ltd.

Product: Cardamonin 19309-14-9
Price: US $0.00/mg
Min. Order: 5mg
Purity: Analytical Standard
Supply Ability: 10 g
Release date: 2019-10-24

Career Henan Chemical Co

Product: CARDAMONIN 19309-14-9
Price: US $1.00/KG
Min. Order: 1g
Purity: 99%
Supply Ability: 100KG
Release date: 2018-12-24

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Alpinetin chalcone

Chalcone, 2', 4'-dihydroxy-6'-methoxy-

(E)-2',4'-Dihydroxy-6'-methoxychalcone

(E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-phenylprop-2-en-1-one

Cardamonin

(E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-phenyl-2-propen-1-one

2-Propen-1-one, 1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenyl-, (2E)-

CARDAMONIN(RG)

(2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-phenyl-2-propen-1-one

Cardamonin (E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-phenylprop-2-en-1-one

(8CI)

Cardamonin, >=98%

Wnt/β-catenin Inhibitor, Cardamonin

Cardamonin, 98%, from Alpinia katsumadai Hayata

Wnt/β-catenin Inhibitor, Cardamonin - CAS 19309-14-9 - Calbiochem

(E)-Cardamonin

CAS19309-14-9 CARDAMONIN

6-Diaminocaproic acid

(E)-Cardamonin ((E)-Cardamomin)

Cardamonin, from Alpinia katsumadai Hayata

19309-14-9

1939-14-9

Inhibitors

Chalcones