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LYSIONOTIN

Product Name
LYSIONOTIN
CAS No.
152743-19-6
Chemical Name
LYSIONOTIN
Synonyms
Nebadensin;LYSIONOTIN;Lysionotin ,98%;shidiaolanjiasu;LYSIONOTIN USP/EP/BP;Lysionotin 152743-19-6;5,7-dihydroxy-6,8-dimethoxy-2-(4-methoxyphenyl)chromen-4-one
CBNumber
CB5254480
Molecular Formula
C18H16O7
Formula Weight
344.317
MOL File
152743-19-6.mol
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological
Product number
300600
Product name
Lysionotin
Packaging
20mg
Price
$320
Updated
2021/12/16
AK Scientific
Product number
X1181
Product name
Lysionotin
Packaging
250mg
Price
$358
Updated
2021/12/16
Biorbyt Ltd
Product number
orb594097
Product name
Lysionotin
Packaging
100mg
Price
$408
Updated
2021/12/16
ApexBio Technology
Product number
N2226
Product name
Lysionotin
Packaging
20mg
Price
$200
Updated
2021/12/16
Biosynth Carbosynth
Product number
FL66117
Product name
Lysionatin
Packaging
1g
Price
$200
Updated
2021/12/16
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LYSIONOTIN Chemical Properties,Usage,Production

Description

Chinese stone Chlorophytum is the whole herb of Lysionotus pauciflorus Maxim, which belongs to Gesneriaceae. Stone Chlorophytum is a small evergreen shrub, which is born in wet places of rock slope and clings to the stone or a tree. Cutting stone Chlorophytum in summer and autumn season when leafiness, removing impu rities, and drying. Stone Chlorophytum is more in Jiangsu, Zhejiang, Anhui, Jiangxi, Hunan, Hubei, Shaanxi, Sichuan, Yunnan, Guizhou, and Guangxi.
Stone Chlorophytum has a long medical history in Yunnan, Guizhou, and south of Qinling region. The function was described in various previous dynasty medicine classics. Stone Chlorophytum tastes bitter, is flat, and goes into the lung, liver, and kidney meridians. It has been recorded in herbal formula that stone Chlorophytum could eliminate sputum and poison, promote digestion, nourish blood, and cure rheumatism, emphysema, dizziness, and various kinds of deficiency. In the classifi cation of herbs, it was recorded that stone Chlorophytum could cure hematemesis, blood vomiting, pain of waist and knee, and contusions. It has been described incommon folk medicinal herbs that stone Chlorophytum could clear the lung to relieve cough, cool blood, and hemostasis .

Physical properties

Appearance: yellow needle crystal or light yellow powder, odorless, and tasteless. Solubility: slightly soluble in chloroform and in methanol, ethanol, or ethyl acetate, very slightly soluble in ether, insoluble in water, and soluble in 5% sodium carbon ate solution, potassium hydroxide, or sodium hydroxide solution. Melting point: 197–199 °C

History

Stone Chlorophytum is the folk antituberculous herb, the fat-soluble component separated from which is lysionotin. China’s scientists for the first time found that lysionotin is the effective component of the antituberculosis in stone Chlorophytum. Xu Yin et al., who worked in Shanghai Institute of Materia Medica, Chinese Academy of Sciences, found that lysionotin is 5,7-dihydroxy 4′,6′,8-trimethoxy flavonoids by structure identification, which is the known compound nevadensin
Farkas et al. used a 14-step synthesis to demonstrate the structure of nevadensin with complex reaction steps. The synthesis route was simpler, which was designed by Tang Cheng-fang in Shanghai Institute of Materia Medica, Chinese Academy of Sciences, and the total yield was ten times higher .
oluble, clinical use of injection caused pain to the patients. In order to overcome the above shortcomings, methylamine glucoside salt of nevadensin was synthesized for intramuscular injection. The effect is significant without causing pain. In order to explore its structure-activity relationship, seven chemical analogues were designed and synthesized with good activity in antibacterial test of Mycobacterium tuberculo sis, which include 6,8-dichloro-4′-methoxyflavone, 6,7-dimethyl-4′-methoxyflavone, 6,7-dichloro-4′-methoxyflavone, dimethoxy-3′, 4′-dimethoxyflavone, 6,7-dichloro-3′, 4′-dimethoxyflavone, 6-chloro-4′-methoxyflavone, and 4-dichloro 6-(4-methoxybenzoyloxy) acetophenone (Fig. 3)

Definition

ChEBI: Nevadensin is a trimethoxyflavone that is flavone substituted by methoxy groups at positions 6, 8 and 4' and hydroxy groups at positions 5 and 7 respectively. It has a role as a plant metabolite. It is a trimethoxyflavone and a dihydroxyflavone. It is functionally related to a flavone. It is a conjugate acid of a nevadensin-7-olate.

Indications

It can make expectoration easy, relieve a cough, soften hard lumps, and dispel nodes. It is used clinically for bronchitis, lymph node tuberculosis, chill cold, etc

Pharmacology

Anti-Mycobacterium tuberculosis, Anti-inflammatory Effect
Nevadensin 200 μg/ml in vitro has obvious anti-Mycobacterium tuberculosis effect; in vivo test also has a protective effect. The treatment for lymph node is sig nificant . Nevadensin has significant inhibitory effect on the experimental arthri tis caused by serotonin, formaldehyde, and kaolin. It also has an inhibitory effect on the cotton ball granuloma. Furthermore, the anti-inflammatory effect does not depend on the presence of adrenal cortex
Antihypertensive Effect
The main role of nevadensin in the central nervous system causes blood pressure reduction, which also has an impact on the peripheral nervous system. Lateral ventricle injection of nevadensin could reduce arterial blood pressure, and the effect of lowering systolic blood pressure was stronger than that of reducing diastolic blood pressure. The mechanism might be that the action of nevadensin on α-adrenergic receptor is stronger than that of the central β-adrenergic receptor.
Scavenging Free Radicals
Phenolic hydroxyl group of nevadensin is the main active group that scavenges free radicals (OH).

Clinical Use

Nevadensin has been used for the adjuvant therapy of cervical lymph node tuberculosis, tuberculosis, bone tuberculosis, and bronchitis treatment. Adverse reactions were mainly nausea, vomiting, diarrhea and abdominal discomfort, etc

LYSIONOTIN Preparation Products And Raw materials

Raw materials

Preparation Products

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LYSIONOTIN Suppliers

Chembest Research Laboratories Limited
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+86-21-20908456
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021-58180499
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sales@BioChemBest.com
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China
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Jia Xing Isenchem Co.,Ltd
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0573-85285100 18627885956
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0573-85285100
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isenchem@163.com
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China
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Sichuan Kulinan Technology Co., Ltd
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400-1166-196 18981987031
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028-84555506 800101999
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cdhxsj@163.com
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China
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Dalian Meilun Biotech Co., Ltd.
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0411-62910999 13889544652
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meilunui@163.com
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China
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Chengdu Ai Keda Chemical Technology Co., Ltd.
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4008-755-333 18080918076
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028-86757656
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800078821@qq.com
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China
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Beijing HuaMeiHuLiBiological Chemical
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010-56205725
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010-65763397
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waley188@sohu.com
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China
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Shanghai Ruji Biology Technology Co., Ltd.
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+86-21-65211385-8001 36031160
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+86-21-65211385-8004
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sales@shruji.com
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China
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Shanghai Tauto Biotech Co., Ltd.
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021-51320588
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0086-21-51320502
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tauto@tautobiotech.com
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China
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3989
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TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
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021-33632979
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marketing@targetmol.com
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China
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7783
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Cheng Du Pufeide Biotechnology Co., Ltd.
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028-82610909 13388174823
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8171-1798
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scglp@glp-china.com
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China
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View Lastest Price from LYSIONOTIN manufacturers

Shanghai Standard Technology Co., Ltd.
Product
Lysionotin 152743-19-6
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2019-10-15
Shanghai Standard Technology Co., Ltd.
Product
Lysionotin 152743-19-6
Price
US $0.00/mg
Min. Order
5mg
Purity
Analytical Standard
Supply Ability
10 g
Release date
2019-10-15
NanJing Spring & Autumn Biological Engineering CO., LTD.
Product
Lysionotin 152743-19-6 152743-19-6
Price
US $10.50/g
Min. Order
1g
Purity
≥98%
Supply Ability
1000.00 kgs
Release date
2019-07-16

152743-19-6, LYSIONOTINRelated Search:


  • LYSIONOTIN
  • shidiaolanjiasu
  • Lysionotin ,98%
  • Lysionotin 152743-19-6
  • 5,7-dihydroxy-6,8-dimethoxy-2-(4-methoxyphenyl)chromen-4-one
  • LYSIONOTIN USP/EP/BP
  • Nebadensin
  • 152743-19-6
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract