MOLLUGIN

Product Name: MOLLUGIN
CAS No.: 55481-88-4
Chemical Name: MOLLUGIN
Synonyms: MOLLUGIN;Rubimaillin;Mollugin-RM;MOLLUGIN(SH);Mollugin/rubiMaillin;RUBIMAILLIN; MOLLUGIN;6-hydroxy-2, 2-dimethyl-, methylester;Mollugin, 98%, from Rubia cordifolia L.;2H-Naphtho[1,2-b]pyran-5-carboxylic acid;Methyl 6-hydroxy-2,2-dimethylbenzo[h]chromene-5-carboxylate
CBNumber: CB4279530
Molecular Formula: C17H16O4
Formula Weight: 284.31
MOL File: 55481-88-4.mol

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MOLLUGIN Property

Melting point:: 132～134℃
Boiling point:: 453.2±45.0 °C(Predicted)
Density: 1.239±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
form: Solid
pka: 8.40±0.40(Predicted)
color: Yellow to Green
InChI: InChI=1S/C17H16O4/c1-17(2)9-8-12-13(16(19)20-3)14(18)10-6-4-5-7-11(10)15(12)21-17/h4-9,18H,1-3H3
InChIKey: VLGATXOTCNBWIT-UHFFFAOYSA-N
SMILES: C12=C3C(C=CC=C3)=C(O)C(C(OC)=O)=C1C=CC(C)(C)O2

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Safety

Safety Statements: 24/25
HS Code: 29329990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHL80499
Product name: Mollugin
Purity: phyproof? Reference Substance
Packaging: 10MG
Price: $427
Updated: 2025/07/31

Sigma-Aldrich

Product number: SMB00431
Product name: Mollugin
Purity: ≥98% (HPLC)
Packaging: 1MG
Price: $137
Updated: 2023/06/20

Sigma-Aldrich

Product number: SMB00431
Product name: Mollugin
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $340
Updated: 2023/06/20

TCI Chemical

Product number: M3091
Product name: Mollugin
Purity: >98.0%(HPLC)
Packaging: 10mg
Price: $77
Updated: 2025/07/31

TCI Chemical

Product number: M3091
Product name: Mollugin
Purity: >98.0%(HPLC)
Packaging: 50mg
Price: $228
Updated: 2025/07/31

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MOLLUGIN Chemical Properties,Usage,Production

Chemical Properties

Derived from the dried root of Rubia cordifolia L.

Uses

Mollugin is an anti-tumor agent inducing apoptosis and autophagy in various cancer models.

Definition

ChEBI: Rubimaillin is a benzochromene that is 2H-benzo[h]chromene which is substituted by two methyl groups at position 2, a methoxycarbonyl group at position 5, and a hydroxy group at position 6. Found in the Chinese medical plant Rubia cordifola, It has an anti-cancer effect by inhibition of TNF-alpha-induced NF-kappaB activation. It is also a dual inhibitor of acyl-CoA:cholesterol acyltransferase 1 and 2 (ACAT1 and ACAT2), but is more selective for the ACAT2 isozyme. It has a role as a plant metabolite, an acyl-CoA:cholesterol acyltransferase 2 inhibitor, a NF-kappaB inhibitor, an antineoplastic agent, an apoptosis inducer, a neuroprotective agent and an anti-inflammatory agent. It is a benzochromene, a methyl ester and a member of phenols.

Biological Activity

Mollugin displays inhibitory activity in arachidonic acid- and collagen-induced platelet aggregation. Mollugin has been reported to inhibit cancer cell proliferation, and has other biological activities including anti-inflammatory and apoptotic effects.

in vivo

Mollugin (0-75 mg/kg, Orally, three times per week for 36 days) inhibits growth of HeLa cells in a xenograft tumor model^[1].

Animal Model:	BALB/c female athymic nude mice (six-week-old, subcutaneously injected with 0.2 mL HeLa cells)^[1]
Dosage:	0, 25 and 75 mg/kg
Administration:	Orally, three times per week for 36 days
Result:	Suppressed tumor growth, whereas the body weight did not change. Significantly reduced the protein expression of p-p65 and COX-2 in the tumors.

MOLLUGIN Preparation Products And Raw materials

Raw materials

Preparation Products

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MOLLUGIN Suppliers

Americas 1 China 214 Europe 1 Germany 1 India 2 Japan 1 United Kingdom 2 United States 14 Global 236

Shaanxi Jianchuang Biotechnology Co., Ltd.

Tel: 13335389838
Email: 3305337057@qq.com
Country: China
ProdList: 221
Advantage: 58

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
Advantage: 61

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14101
Advantage: 59

Shandong Xiya Chemical Co., Ltd

Tel: 4009903999 13355009207
Fax: 0539-6365991
Email: 3007715519@qq.com
Country: China
ProdList: 18729
Advantage: 57

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7811
Advantage: 57

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4747
Advantage: 58

BioBioPha Co., Ltd.

Tel: 0871-65217109 13211707573;
Fax: 0871-65215563
Email: y.liu@mail.biobiopha.com
Country: China
ProdList: 5653
Advantage: 65

Chengdu Biopurify Phytochemicals Ltd.

Tel: +86-028-82633397 18982077548
Fax: +86-28-82633165
Email: cwb1@biopurify.cn
Country: China
ProdList: 2376
Advantage: 60

Chengdu Climax Biotech Co., Ltd.

Tel: 028-83311324 1278112614
Fax: 028-83311324
Email: climaxbiotech@gmail.com
Country: China
ProdList: 925
Advantage: 58

Shanghai Winherb Medical Technology Co., Ltd.

Tel: 021-38218169 13341702378
Fax: QQ：190129269
Email: winherb@126.com
Country: China
ProdList: 1245
Advantage: 58

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View Lastest Price from MOLLUGIN manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Mollugin 55481-88-4
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2019-10-08

Shanghai Standard Technology Co., Ltd.

Product: Mollugin 55481-88-4
Price: US $0.00/mg
Min. Order: 5mg
Purity: Analytical Standard
Supply Ability: 10 g
Release date: 2019-10-08

Career Henan Chemical Co

Product: MOLLUGIN 55481-88-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2019-05-25

55481-88-4, MOLLUGINRelated Search:

ASARININ Paederosidic acid Jujuboside B Astragaloside II Dihydromollugin 1-Hydroxy-2-naphthoic acid Trifluoromethoxybenzaldehyde2 1-ALLYLOXYNAPHTHALENE 1,4-Dihydroxy-2-naphthoic acid METHYL 5-METHOXYSALICYLATE MOLLUGIN 4-METHOXY-1-NAPHTHOL 5-Methoxysalicylic acid 3-ALLYLOXY-BENZOIC ACID 3-(ALLYLOXY)BENZALDEHYDE METHYL 1-HYDROXY-2-NAPHTHOATE 1-(Allyloxy)-4-(hydroxymethyl)benzene 5-ETHOXYSALICYLIC ACID

Rubimaillin

2H-Naphtho[1,2-b]pyran-5-carboxylic acid

6-hydroxy-2, 2-dimethyl-, methylester

2,2-Dimethyl-6-hydroxy-2H-naphtho[1,2-b]pyran-5-carboxylic acid methyl ester

6-Hydroxy-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5-carboxylic acid methyl ester

MOLLUGIN

Methyl 6-hydroxy-2,2-dimethylbenzo[h]chromene-5-carboxylate

RUBIMAILLIN; MOLLUGIN

Mollugin/rubiMaillin

2-DiMethyl-6-hydroxy-2H-naphtho[1,2-b]pyran-5-carboxylic acid Methyl ester

MOLLUGIN(SH)

Mollugin, 98%, from Rubia cordifolia L.

2H-Naphtho[1,2-b]pyran-5-carboxylic acid, 6-hydroxy-2,2-dimethyl-, methyl ester

6-Hydroxy-2,2-dimethyl-2H-benzo[h]chromene-5-carboxylic Acid Methyl Ester

Methyl 6-Hydroxy-2,2-dimethyl-2H-benzo[h]chromene-5-carboxylate

Mollugin-RM

55481-88-4

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

reference substance