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ASARININ

Product Name
ASARININ
CAS No.
133-04-0
Chemical Name
ASARININ
Synonyms
ASARININ;L-Asarinin;EPI-SESAMIN;(-)-ASARININ;(-)-SESAMINE;(-)-Episesamin;Eleutheroside B4;TIANFU CHEM-- ASARININ;ASARININ(RG)(SEE SESAMIN);(-)-Asarinin, 10 mM in DMSO
CBNumber
CB4703390
Molecular Formula
C20H18O6
Formula Weight
354.35
MOL File
133-04-0.mol
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ASARININ Property

Melting point:
121°
alpha 
D20 -118.6°; D23 -122° (chloroform)
Boiling point:
504.4±50.0 °C(Predicted)
Density 
1.385±0.06 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
Chloroform (Slightly), DMSO (Slightly, Sonicated)
form 
Solid
color 
White to Off-White
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
27456
Product name
Asarinin
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
27456
Product name
Asarinin
Packaging
25mg
Price
$456
Updated
2024/03/01
Cayman Chemical
Product number
27456
Product name
Asarinin
Packaging
5mg
Price
$122
Updated
2024/03/01
Cayman Chemical
Product number
27456
Product name
Asarinin
Packaging
10mg
Price
$214
Updated
2024/03/01
Usbiological
Product number
361818
Product name
L-Asarinin
Packaging
20mg
Price
$390
Updated
2021/12/16
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ASARININ Chemical Properties,Usage,Production

Description

Asarinin is a lignan that has been found in A. sieboldii. It is an epimer of sesamin and a noncompetitive inhibitor of Δ5-desaturase (Ki = 0.28 mM). It is selective for Δ5-desaturase over Δ6- and Δ9-desaturase. Asarinin is cytotoxic to A2780 and SKOV3 ovarian cancer cells (IC50s = 38.45 and 60.87 μM, respectively) but not immortalized ovarian surface epithelial cells (IC50 = >200 μM). It induces apoptosis and activates caspase-3, -8, and -9 in A2780 and SKOV3 cells.

Chemical Properties

White needle-like crystals, soluble in boiling methanol, ethanol, chloroform, acetone, benzene, practically insoluble in water, from A. sarum .sieboldii pepper pepper Zanthoxylum piperitum, hairy puffball Paulownia tomentosa, two-faced needle.

Uses

l-Asarinin in combination with pellitorine is a potential larvicides for the control of insecticide-resistant mosquito populations. Possesses antimicrobial activity.

in vivo

(-)-Asarinin (5-20 mg/kg; gavage; once daily; 16 weeks) improves the morphology of gastric mucosal glands, alleviate intestinal metaplasia, inhibit the STAT3 pathway, promote ROS accumulation, and induce apoptosis of gastric mucosal cells in the N-Nitroso-N-methylurea (MNU) (HY-34758)-induced mouse model of gastric precancerous lesions[1].
(-)-Asarinin (5.0 mg/kg; oral administration; before intranasal OVA challenge) significantly inhibits the allergic reaction, reduces paw swelling and Evans blue exudation in mice, and decreases the degree of mast cell degranulation in the skin in the OVA-induced passive cutaneous anaphylaxis mouse model[3].
(-)-Asarinin (2.50 mg/kg; oral administration) reduces the concentrations of histamine, TNF-α, MCP-1, IL-4, and IL-5 in the serum of mice in the OVA - induced systemic anaphylaxis mouse model<[3].
(-)-Asarinin (5.0 mg/kg; oral administration; once daily; from day 21-28) significantly inhibits the scratching and sneezing responses of mice, reduces the concentrations of histamine, total IgE, and IL-4 in the serum of mice, and alleviates the inflammatory infiltration and thickening of the nasal mucosa in the OVA-induced allergic rhinitis mouse model[3].
(-)-Asarinin (2.5 mg/kg, 5.0 mg/kg, 10 mg/kg; oral administration) inhibits paw swelling and Evans blue exudation in mice and reduces the concentrations of histamine, TNF-α, MCP-1, and IL-8 in the serum in the C48/80-induced allergic reaction mouse model[3].
C57BL/6 mice (male, 18-22 g), OVA-induced passive cutaneous anaphylaxis model3 5.0 mg/kg Oral administration Significantly suppressed passive cutaneous anaphylaxis (PCA) in mice, reduced the degree of swelling and Evens blue exudation of mice paw, and decreased the degree of degranulation of MCs in skin. C57BL/6 mice (male, 18-22 g), OVA-induced passive cutaneous anaphylaxis model3 2.50 mg/kg Oral administration Significantly reduced the concentration of histamine, TNF-α, MCP-1, IL-4 and IL-5 in mice serum. C57BL/6 mice (male, 18-22 g), OVA-induced passive cutaneous anaphylaxis model3 5.0 mg/kg Oral administration, once daily, from day 21 - 28 Significantly inhibited the scratching and sneezing response of mice, reduced the concentration of histamine, total IgE, and IL - 4 in mice serum, and attenuated the inflammatory infiltrates and nasal mucosa incrassation in the AR mice. C57BL/6 mice (male, 18-22 g), C48/80-induced allergic reaction model3 2.5 mg/kg, 5.0 mg/kg, 10 mg/kg Oral administration Reduced C48/80-induced paw swelling and Evens blue exudation, and decreased the concentration of histamine, TNF-α, MCP-1 and IL-8 in mice serum.

Animal Model:Animal Model: SPF-grade BALB/c mice (male and female, 18-20 g, 4-week-old), established by administration of carcinogenic agent MNU[1]
Dosage:20 mg/kg, 5 mg/kg
Administration:Gavage, once daily, 16 weeks
Result:Reversed the deterioration of the gastric mucosal glands' morphology, reduced the severity of intestinal metaplasia, promoted ROS accumulation, inhibited the STAT3 pathway, and induced apoptosis in the gastric mucosa of GPL mice.
Animal Model:C57BL/6 mice (male, 18-22 g), OVA-induced passive cutaneous anaphylaxis model[3]
Dosage:5.0 mg/kg
Administration:Oral administration
Result:Significantly suppressed passive cutaneous anaphylaxis (PCA) in mice, reduced the degree of swelling and Evens blue exudation of mice paw, and decreased the degree of degranulation of MCs in skin.
Animal Model:C57BL/6 mice (male, 18-22 g), OVA-induced passive cutaneous anaphylaxis model[3]
Dosage:5 mg/kg
Administration:Oral administration, once daily, from day 21-28
Result:Significantly inhibited the scratching and sneezing response of mice, reduced the concentration of histamine, total IgE, and IL - 4 in mice serum, and attenuated the inflammatory infiltrates and nasal mucosa incrassation in the AR mice.
Animal Model:C57BL/6 mice (male, 18-22 g), OVA-induced passive cutaneous anaphylaxis model3
Dosage:2.50 mg/kg
Administration:Oral administration
Result:Significantly reduced the concentration of histamine, TNF-α, MCP-1, IL-4 and IL-5 in mice serum.
Animal Model:C57BL/6 mice (male, 18-22 g), C48/80-induced allergic reaction model3
Dosage:2.5 mg/kg, 5.0 mg/kg, 10 mg/kg
Administration:Oral administration
Result:Reduced C48/80-induced paw swelling and Evens blue exudation, and decreased the concentration of histamine, TNF-α, MCP-1 and IL-8 in mice serum.

target

IL Receptor | IFN-γ | CXCR | TLR

References

[1] MIRAN JEONG. (-)-Asarinin from the Roots of Asarum sieboldii Induces Apoptotic Cell Death via Caspase Activation in Human Ovarian Cancer Cells.[J]. Molecules, 2018, 23 8. DOI: 10.3390/molecules23081849
[2] SAKAYU SHIMIZU. Inhibition of Δ5-desaturase in polyunsaturated fatty acid biosynthesis by (?)-asarinin and (?)-epiasarinin[J]. Phytochemistry, 1992, 31 3: Pages 757-760. DOI: 10.1016/0031-9422(92)80008-3

ASARININ Preparation Products And Raw materials

Raw materials

Preparation Products

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ASARININ Suppliers

China 165 New Zealand 1 United Kingdom 3 United States 12 Global 181
Chembest Research Laboratories Limited
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+86-21-20908456
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021-58180499
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sales@BioChemBest.com
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China
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Sichuan Kulinan Technology Co., Ltd
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400-1166-196 18981987031
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028-84555506 800101999
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China
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Dalian Meilun Biotech Co., Ltd.
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0411-62910999 13889544652
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sales@meilune.com
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BioBioPha Co., Ltd.
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0871-65217109 13211707573;
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0871-65215563
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y.liu@mail.biobiopha.com
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China
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ShangHai YuanYe Biotechnology Co., Ltd.
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021-61312847 13636370518
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021-55068248
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shyysw007@163.com
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Chengdu Biopurify Phytochemicals Ltd.
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+86-028-82633397 18982077548
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+86-28-82633165
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cwb1@biopurify.cn
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China
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The future of Shanghai Industrial Co., Ltd.
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021-61552785
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Shanghai Ruji Biology Technology Co., Ltd.
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+86-21-65211385-8001 36031160
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+86-21-65211385-8004
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Shanghai Tauto Biotech Co., Ltd.
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021-51320588
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0086-21-51320502
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TargetMol Chemicals Inc.
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021-021-33632979 15002134094
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021-33632979
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View Lastest Price from ASARININ manufacturers

Shanghai Standard Technology Co., Ltd.
Product
Asarinin 133-04-0
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2019-12-27
Career Henan Chemical Co
Product
ASARININ 133-04-0
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
25kg
Release date
2019-07-12

133-04-0, ASARININRelated Search:

(-)-ASARININ 97,(-)-ASARININ 97%,ASARININ(P) Asatone Epmedin B Ganoderenic acid D MOLLUGIN Paederosidic acid Jujuboside B Astragaloside II Sesamin ENTERODIOL ASARININ (R)-(+)-2-METHYL-1-PHENYL-1-PROPANOL Masoprocol 4-(4-METHOXYPHENYL)-1-BUTANOL Vanillyl butyl ether (1R)-1-(3-METHOXYPHENYL)ETHANOL 3-BENZO[1,3]DIOXOL-5-YL-PROPAN-1-OL 2,3-dibenzylbutane-1,4-diol

  • (-)-SESAMINE
  • (-)-ASARININ
  • ASARININ
  • EPI-SESAMIN
  • (-)-5,5'-[(1R,3aα,4S,6aα)-Tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl]bis[1,3-benzodioxole]
  • 5,5'-[(1R,3aα,4S,6aα)-Tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl]bis(1,3-benzodioxole)
  • L-Asarinin
  • 5-[4-(1,3-benzodioxol-5-yl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-1-yl]-1,3-benzodioxole
  • ASARININ(RG)(SEE SESAMIN)
  • Asarinin, 98%, from Aristolochia debilis Sieb. & Zucc.
  • Eleutheroside B4
  • 1,3-Benzodioxole, 5,5'-[(1R,3aS,4S,6aS)-tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl]bis-
  • 5-[(3R,3aS,6S,6aS)-3-(1,3-benzodioxol-5-yl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-6-yl]-1,3-benzodioxole
  • (-)-Episesamin
  • TIANFU CHEM-- ASARININ
  • (1R,3aS,4S,6aS)-1,4-Bis(benzo[d][1,3]dioxol-5-yl)tetrahydro-1H,3H-furo[3,4-c]furan
  • (-)-Asarinin, 10 mM in DMSO
  • 133-04-0
  • Lichen Products