Ganoderenic acid D
- Product Name
- Ganoderenic acid D
- CAS No.
- 100665-43-8
- Chemical Name
- Ganoderenic acid D
- Synonyms
- Ganoderenic acid d;Apoptosis,Inhibitor,inhibit,Ganoderenic acid D;(20E)-7β-Hydroxy-3,11,15,23-tetraoxolanosta-8,20(22)-diene-26-oic acid;(20E)-7β-Hydroxy-3,11,15,23-tetraoxo-5α-lanosta-8,20(22)-dien-26-oic acid;(7beta,20E)-7-Hydroxy-3,11,15,23-tetraoxolanosta-8,20(22)-dien-26-oic acid;Lanosta-8,20(22)-dien-26-oic acid, 7-hydroxy-3,11,15,23-tetraoxo-, (7β,20E)-;(E)-6-((5R,7S,10S,13R,14R,17R)-7-Hydroxy-4,4,10,13,14-pentamethyl-3,11,15-trioxo-2,3,4,5,6,7,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-methyl-4-oxohept-5-enoic acid
- CBNumber
- CB52192797
- Molecular Formula
- C30H40O7
- Formula Weight
- 512.6344
- MOL File
- 100665-43-8.mol
Ganoderenic acid D Property
- Melting point:
- 218-220℃
- Boiling point:
- 702.3±60.0 °C(Predicted)
- Density
- 1.24±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- form
- Powder
- pka
- 4.63±0.23(Predicted)
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- 300301
- Product name
- Ganoderenic acid D
- Packaging
- 10mg
- Price
- $490
- Updated
- 2021/12/16
- Product number
- orb259246
- Product name
- Ganoderenic acid D
- Purity
- 98%
- Packaging
- 5mg
- Price
- $654.5
- Updated
- 2021/12/16
- Product number
- 3481
- Product name
- Ganoderenic acid D
- Packaging
- 10mg
- Price
- $590
- Updated
- 2021/12/16
- Product number
- 3481
- Product name
- Ganoderenic acid D
- Packaging
- 2mg
- Price
- $249
- Updated
- 2021/12/16
- Product number
- CFN90300
- Product name
- GanoderenicacidD
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $476
- Updated
- 2021/12/16
Ganoderenic acid D Chemical Properties,Usage,Production
Chemical Properties
White powder, soluble in organic solvents such as methanol, ethanol, and DMSO. It is derived from the dried fruiting body of Ganoderma lucidum (Leyss. exFr.) Karst. of the Polyporaceae family.
Uses
Ganoderic acid D, a highly oxygenated tetracyclic triterpenoid, is the major active component of Ganoderma lucidum. Ganoderic acid D upregulates the protein expression of SIRT3 and induces the deacetylated cyclophilin D (CypD) by SIRT3. It inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate production, pyruvate and acetyl-coenzyme production in colon cancer cells. It also induces HeLa human cervical carcinoma apoptosis.
Definition
ChEBI: Ganoderenic acid D is a triterpenoid.
Biological Activity
Ganoderenic acid D is a triterpenoid originally isolated from G. lucidum and has diverse biological activities. It inhibits angiotensin-converting enzyme (ACE; IC50 = 734 μM). Ganoderenic acid D is cytotoxic to HepG2 liver, HeLa cervical, and Caco-2 colon cancer cells (IC50s = 0.14, 0.18, and 0.26 mg/ml, respectively). It inhibits LPS-induced nitric oxide (NO) production in BV-2 microglia (IC50 = 13.77 μM).
References
[1] TRAN HAI-BANG Kuniyoshi S. Structure–activity relationship and inhibition pattern of reishi-derived (Ganoderma lingzhi) triterpenoids against angiotensin-converting enzyme[J]. Phytochemistry Letters, 2015, 12: Pages 243-247. DOI: 10.1016/j.phytol.2015.04.021
[2] WEIMEI RUAN. Extraction optimisation and isolation of triterpenoids from Ganoderma lucidum and their effect on human carcinoma cell growth.[J]. Natural Product Research, 2014, 28 24: 2264-2272. DOI: 10.1080/14786419.2014.938337
[3] YANG JIAO . Lanostane triterpenoids from Ganoderma curtisii and their NO production inhibitory activities of LPS-induced microglia[J]. Bioorganic & Medicinal Chemistry Letters, 2016, 26 15: Pages 3556-3561. DOI: 10.1016/j.bmcl.2016.06.023
Ganoderenic acid D Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ganoderenic acid D manufacturers
- Product
- Ganoderenic acid D 100665-43-8
- Price
- US $0.00/mg
- Min. Order
- 5mg
- Purity
- ≥98%(HPLC)
- Supply Ability
- 10 g
- Release date
- 2020-04-13
- Product
- Ganoderenic acid D 100665-43-8
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1kg , 5kg, 50kg
- Release date
- 2020-01-17