ChemicalBook > CAS DataBase List > Ganoderenic acid D

Ganoderenic acid D

Product Name: Ganoderenic acid D
CAS No.: 100665-43-8
Chemical Name: Ganoderenic acid D
Synonyms: Ganoderenic acid d;Apoptosis,Inhibitor,inhibit,Ganoderenic acid D;(20E)-7β-Hydroxy-3,11,15,23-tetraoxolanosta-8,20(22)-diene-26-oic acid;(20E)-7β-Hydroxy-3,11,15,23-tetraoxo-5α-lanosta-8,20(22)-dien-26-oic acid;(7beta,20E)-7-Hydroxy-3,11,15,23-tetraoxolanosta-8,20(22)-dien-26-oic acid;Lanosta-8,20(22)-dien-26-oic acid, 7-hydroxy-3,11,15,23-tetraoxo-, (7β,20E)-;(E)-6-((5R,7S,10S,13R,14R,17R)-7-Hydroxy-4,4,10,13,14-pentamethyl-3,11,15-trioxo-2,3,4,5,6,7,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-methyl-4-oxohept-5-enoic acid
CBNumber: CB52192797
Molecular Formula: C30H40O7
Formula Weight: 512.6344
MOL File: 100665-43-8.mol

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Ganoderenic acid D Property

Melting point:: 218-220℃
Boiling point:: 702.3±60.0 °C(Predicted)
Density: 1.24±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: Powder
pka: 4.63±0.23(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological

Product number: 300301
Product name: Ganoderenic acid D
Packaging: 10mg
Price: $490
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb259246
Product name: Ganoderenic acid D
Purity: 98%
Packaging: 5mg
Price: $654.5
Updated: 2021/12/16

AvaChem

Product number: 3481
Product name: Ganoderenic acid D
Packaging: 10mg
Price: $590
Updated: 2021/12/16

AvaChem

Product number: 3481
Product name: Ganoderenic acid D
Packaging: 2mg
Price: $249
Updated: 2021/12/16

Arctom

Product number: CFN90300
Product name: GanoderenicacidD
Purity: ≥98%
Packaging: 10mg
Price: $476
Updated: 2021/12/16

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Ganoderenic acid D Chemical Properties,Usage,Production

Chemical Properties

White powder, soluble in organic solvents such as methanol, ethanol, and DMSO. It is derived from the dried fruiting body of Ganoderma lucidum (Leyss. exFr.) Karst. of the Polyporaceae family.

Uses

Ganoderic acid D, a highly oxygenated tetracyclic triterpenoid, is the major active component of Ganoderma lucidum. Ganoderic acid D upregulates the protein expression of SIRT3 and induces the deacetylated cyclophilin D (CypD) by SIRT3. It inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate production, pyruvate and acetyl-coenzyme production in colon cancer cells. It also induces HeLa human cervical carcinoma apoptosis.

Definition

ChEBI: Ganoderenic acid D is a triterpenoid.

Biological Activity

Ganoderenic acid D is a triterpenoid originally isolated from G. lucidum and has diverse biological activities. It inhibits angiotensin-converting enzyme (ACE; IC50 = 734 μM). Ganoderenic acid D is cytotoxic to HepG2 liver, HeLa cervical, and Caco-2 colon cancer cells (IC50s = 0.14, 0.18, and 0.26 mg/ml, respectively). It inhibits LPS-induced nitric oxide (NO) production in BV-2 microglia (IC50 = 13.77 μM).

References

[1] TRAN HAI-BANG Kuniyoshi S. Structure–activity relationship and inhibition pattern of reishi-derived (Ganoderma lingzhi) triterpenoids against angiotensin-converting enzyme[J]. Phytochemistry Letters, 2015, 12: Pages 243-247. DOI: 10.1016/j.phytol.2015.04.021
[2] WEIMEI RUAN. Extraction optimisation and isolation of triterpenoids from Ganoderma lucidum and their effect on human carcinoma cell growth.[J]. Natural Product Research, 2014, 28 24: 2264-2272. DOI: 10.1080/14786419.2014.938337
[3] YANG JIAO . Lanostane triterpenoids from Ganoderma curtisii and their NO production inhibitory activities of LPS-induced microglia[J]. Bioorganic & Medicinal Chemistry Letters, 2016, 26 15: Pages 3556-3561. DOI: 10.1016/j.bmcl.2016.06.023

Ganoderenic acid D Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Ganoderenic acid D manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Ganoderenic acid D 100665-43-8
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2020-04-13

Career Henan Chemical Co

Product: Ganoderenic acid D 100665-43-8
Price: US $3.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1kg , 5kg, 50kg
Release date: 2020-01-17

100665-43-8, Ganoderenic acid DRelated Search:

LUCIDENIC ACID D2(SH) (5alpha,7beta)-7-Hydroxy-4,4,14-trimethyl-3,11,15-trioxo-chola-8,20-dien-24-oic acid Lucidenic acid L 23S-hydroxyl-11,15-dioxo-ganoderic acid DM Lucidenic acid B Lucidenic acid C Ganoderenic acid E VIGABATRIN ECHINOCYSTIC ACID Epmedin B ASARININ MOLLUGIN Paederosidic acid Jujuboside B Astragaloside II Ganoderenic acid B (20E)-3β,7β,15α-Trihydroxy-11,23-dioxo-5α-lanosta-8,20(22)-dien-26-oic acid ganoderenic acid A

(20E)-7β-Hydroxy-3,11,15,23-tetraoxo-5α-lanosta-8,20(22)-dien-26-oic acid

(20E)-7β-Hydroxy-3,11,15,23-tetraoxolanosta-8,20(22)-diene-26-oic acid

(7beta,20E)-7-Hydroxy-3,11,15,23-tetraoxolanosta-8,20(22)-dien-26-oic acid

Ganoderenic acid d

Apoptosis,Inhibitor,inhibit,Ganoderenic acid D

(E)-6-((5R,7S,10S,13R,14R,17R)-7-Hydroxy-4,4,10,13,14-pentamethyl-3,11,15-trioxo-2,3,4,5,6,7,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-methyl-4-oxohept-5-enoic acid

Lanosta-8,20(22)-dien-26-oic acid, 7-hydroxy-3,11,15,23-tetraoxo-, (7β,20E)-

100665-43-8

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract