Asatone

Product Name: Asatone
CAS No.: 38451-63-7
Chemical Name: Asatone
Synonyms: Asatone;Asatone A;Asatone USP/EP/BP;Asatone, 10 mM in DMSO;NF-κB,inhibit,Asatone,Nuclear factor-κB,Inhibitor,Nuclear factor-kappaB;rel-(1R,4S,4aS,8aS)-3,8a-Diallyl-1,5,5,7,9,9-hexamethoxy-1,4a,5,8a-tetrahydro-1,4-ethanonaphthalene-6,10(4H)-dione;1,4-Ethanonaphthalene-6,10(4H)-dione, 1,4a,5,8a-tetrahydro-1,5,5,7,9,9-hexamethoxy-3,8a-di-2-propen-1-yl-, (1R,4S,4aS,8aS)-rel-
CBNumber: CB11469357
Molecular Formula: C24H32O8
Formula Weight: 448.51
MOL File: 38451-63-7.mol

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Asatone Property

Boiling point:: 536.1±50.0 °C(Predicted)
Density: 1.19±0.1 g/cm3(Predicted)
storage temp.: 4°C, protect from light
solubility: Soluble in DMSO
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0100242
Product name: Asatone
Purity: 99.88%
Packaging: 1mg
Price: $120
Updated: 2021/12/16

AK Scientific

Product number: 2482CC
Product name: Asatone
Packaging: 1mg
Price: $237
Updated: 2021/12/16

ChemScene

Product number: CS-0100242
Product name: Asatone
Purity: 99.88%
Packaging: 5mg
Price: $260
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb594619
Product name: Asatone
Packaging: 10mg
Price: $513.4
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb594619
Product name: Asatone
Packaging: 20mg
Price: $666.4
Updated: 2021/12/16

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Asatone Chemical Properties,Usage,Production

Chemical Properties

Blocky white crystals, soluble in methanol, ethanol, DMSO and other organic solvents, derived from AsarumsieboldiiMiq.

Uses

Asatone is an active component isolated from Radix et Rhizoma Asari, with anti-inflammatory effect via activation of NF-κB and donwn regulation of p-MAPK (ERK, JNK and p38) pathways[1].

Biological Activity

Asatone, an active ingredient isolated from Asarum, has anti-inflammatory activity by activating NF-κB and downregulating p-MAPK (ERK, JNK and p38) pathways.

Synthesis

Asatone was prepared as follows: air-dried whole powdered air-dried powder (28 kg) of the whole plant of Asarum was extracted with 70% ethanol (3 150 L) under reflux for a total of 6 h, and then the solvent was removed under reduced pressure. The 70% ethanol extract (4360 g) was suspended in water and sequentially partitioned with light petroleum (60-90oC), CHCl3, EtOAc and n-butyl OH. The light petroleum layer (260 g) was subjected to silica gel CC elution and gradient elution with n-hexane-EtOAc (30:1 to 0:1) to give 32 fractions (P-fractions 1-32). Semi-preparative HPLC (85% MeOH in H2O) was performed on P-fraction 6 to give asatone (25 mg).

target

NF-κB

References

[1] Chang HY, et al. Asatone Prevents Acute Lung Injury by Reducing Expressions of NF-[Formula: see text]B, MAPK and Inflammatory Cytokines. Am J Chin Med. 2018;46(3):651-671. DOI:10.1142/S0192415X18500349

Asatone Preparation Products And Raw materials

Raw materials

Preparation Products

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Asatone Suppliers

China 59 United States 4 Global 63

BioBioPha Co., Ltd.

Tel: 0871-65217109 13211707573;
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Country: China
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Advantage: 65

ShangHai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847 13636370518
Fax: 021-55068248
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Country: China
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Chengdu Biopurify Phytochemicals Ltd.

Tel: +86-028-82633397 18982077548
Fax: +86-28-82633165
Email: cwb1@biopurify.cn
Country: China
ProdList: 2376
Advantage: 60

Shanghai Tauto Biotech Co., Ltd.

Tel: 021-51320588
Fax: 0086-21-51320502
Email: tauto@tautobiotech.com
Country: China
ProdList: 3988
Advantage: 66

Chengdu Herbpurify Co.Ltd.

Tel: 2355253622; 18981954830
Fax: 086-28-85377358
Email: 2355253622@qq.com;
Country: China
ProdList: 1089
Advantage: 58

Wuhan ChemFaces Biochemical Co., Ltd.

Tel: 18607101326 15172504745
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Country: China
ProdList: 6905
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Shandong Xiya Chemical Co., Ltd.

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Country: China
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Beijing Jin Ming Biotechnology Co., Ltd.

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ProdList: 12306
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Shanghai Uteam Biotechnology Co., Ltd.

Tel: 021-36031160 13311776681
Email: 3338195766@QQ.com
Country: China
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Shanghai Biological Technology Development Co., Ltd.

Tel: 021-69955236-807 13918189704
Fax: 021-65211385
Email: chinaruji@chinaruji.com
Country: China
ProdList: 5095
Advantage: 55

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View Lastest Price from Asatone manufacturers

Shaanxi Haibo Biotechnology Co., Ltd

Product: Asatone 38451-63-7
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000ton
Release date: 2023-08-25

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Asatone

1,4-Ethanonaphthalene-6,10(4H)-dione, 1,4a,5,8a-tetrahydro-1,5,5,7,9,9-hexamethoxy-3,8a-di-2-propen-1-yl-, (1R,4S,4aS,8aS)-rel-

Asatone USP/EP/BP

Asatone A

NF-κB,inhibit,Asatone,Nuclear factor-κB,Inhibitor,Nuclear factor-kappaB

rel-(1R,4S,4aS,8aS)-3,8a-Diallyl-1,5,5,7,9,9-hexamethoxy-1,4a,5,8a-tetrahydro-1,4-ethanonaphthalene-6,10(4H)-dione

Asatone, 10 mM in DMSO

38451-63-7