beta-Sitosterol

Product Name: beta-Sitosterol
CAS No.: 83-46-5
Chemical Name: beta-Sitosterol
Synonyms: β-Sitosterol;SITOSTEROL;PHYTOSTEROL;B-SITOSTEROL;22,23-DIHYDROSTIGMASTEROL;Sterol;Stigmast-5-en-3beta-ol;sobatum;Quebrachol;nimbosterol
CBNumber: CB4345688
Molecular Formula: C29H50O
Formula Weight: 414.72
MOL File: 83-46-5.mol

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beta-Sitosterol Property

Melting point:: 136-140 °C(lit.)
Boiling point:: 473.52°C (rough estimate)
alpha: -28 º (c=2, CHCl3)
Density: 0.9540 (rough estimate)
refractive index: 1.5000 (estimate)
storage temp.: 2-8°C
solubility: chloroform: 20 mg/mL, clear, colorless
form: White solid
pka: 15.03±0.70(Predicted)
color: White to Off-White
biological source: synthetic
optical activity: -3725 (c 2, CHCl3)
Water Solubility: INSOLUBLE
Merck: 14,8556
BRN: 1916165
InChIKey: KZJWDPNRJALLNS-VJSFXXLFSA-N
LogP: 10.482 (est)
CAS DataBase Reference: 83-46-5(CAS DataBase Reference)
NIST Chemistry Reference: «beta»-Sitosterol(83-46-5)
EPA Substance Registry System: .beta.-Sitosterol (83-46-5)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-38-40-48/20/22-36/37/38-67-36/38-20-63
Safety Statements: 22-24/25-36-26-36/37
RIDADR: UN 1888 6.1/PG 3
WGK Germany: 3
RTECS: WJ2600000
F: 10
HS Code: 29061990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

H336May cause drowsiness or dizziness

H351Suspected of causing cancer

H372Causes damage to organs through prolonged or repeated exposure

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P273Avoid release to the environment.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y0001615
Product name: Beta-sitosterol
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: 25 mg
Price: $236
Updated: 2025/07/31

Sigma-Aldrich

Product number: PHR2693
Product name: β-Sitosterol
Purity: Pharmaceutical Secondary Standard; Certified Reference Material, certified reference material, pharmaceutical secondary standard, pkg of 200?mg
Packaging: 200MG
Price: $314
Updated: 2025/07/31

Sigma-Aldrich

Product number: PHL89283
Product name: β-Sitosterol
Purity: phyproof? Reference Substance
Packaging: 25MG
Price: $403
Updated: 2025/07/31

Sigma-Aldrich

Product number: 567152
Product name: β-Sitosterol - CAS 83-46-5 - Calbiochem
Purity: Common plant steroid that possesses anticholesteremic properties.
Packaging: 5G
Price: $56.2
Updated: 2025/07/31

Sigma-Aldrich

Product number: 567152
Product name: β-Sitosterol - CAS 83-46-5 - Calbiochem
Purity: Common plant steroid that possesses anticholesteremic properties.
Packaging: 25G
Price: $258
Updated: 2025/07/31

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beta-Sitosterol Chemical Properties,Usage,Production

Description

24α-ethyl Cholesterol is a naturally occurring plant sterol with antioxidant, anticancer, anti-inflammatory, angiogenic, chemopreventive, and immunomodulatory activities. It inhibits the absorption of dietary and endogenously-produced cholesterol from the small intestine, reducing blood cholesterol concentrations. Because of its nutraceutical benefits, 24α-ethyl cholesterol has been used as a food additive intended to lower LDL cholesterol. 24α-ethyl Cholesterol (0.1 - 100 μM) can dose-dependently induce adipogenesis and lipolysis in rat primary preadipocytes as well as stimulate glucose uptake in differentiated adipocytes.

Chemical Properties

White powder

Uses

antiinflammatory, immunomodulator

Uses

A common sterol in plants. Isolated from wheat germ oil, corn oil. Antilipemic. Used in the treatment of prostatic adenoma.This compound is a contaminant of emerging concern (CECs)

Definition

A steroid with long aliphatic side chains (8–10 carbons) and at least one hydroxyl group. They are lipidsoluble and often occur in membranes. Examples are cholesterol and ergosterol.

Definition

sterol: Any of a group of steroidbasedalcohols having a hydrocarbonside-chain of 8–10 carbon atoms.Sterols exist either as free sterols oras esters of fatty acids. Animal sterols(zoosterols) include cholesterol andlanosterol. The major plant sterol(phytosterol) is beta-sitosterol, whilefungal sterols (mycosterols) includeergosterol.

Definition

ChEBI: A phytosterols that is stigmast-5-ene substituted by a beta-hydroxy group at position 3.

General Description

Sitosterol, also called as β-sitosterol, is synthesized through the mevalonate and deoxy xylulose pathways. Synthetically, it is synthesized from stigmasterol by Δ22–23 alkene group hydrogenation. Structurally sitosterol differ from cholesterol with ethyl (sitosterol) group in C24 position of side chain(65). Sitosterol is a lipid component of membranes. It corresponds to a molecular mass of 414.71 g/mol).

Biochem/physiol Actions

Sitosterol promotes the antioxidant levels and is used as an effective anti-inflammatory, antiapoptotic and anticancer agent in medicinal preparations. It acts as a neutralizing agent for the venom from viper and cobra. Sitosterol acts on protein kinase C (PKC) and in the sphingomyelin cycle to mediate tumor progression inhibition.

Purification Methods

Crystallise -sitosterol from EtOH, MeOH, Me2CO, Me2CO/EtOH or Me2CO/MeOH. It has also been purified by zone melting. The acetate crystallises from MeOH or EtOH as plates with m 127128o and [] D 20 -41o (c 2, CHCl3). The benzoate crystallises from EtOH as needles with m 146-147o and [] D 20 –13.8o (c 2, CHCl3). [Fujimoto & Jacobson J Org Chem 29 3377, 3381 1964, Shoppee J Chem Soc 10431948, Heilbron et al. J Chem Soc 344, 347 1941, Beilstein 6 III 2696.]

References

[1] X.C. WENG W. W. Antioxidant activity of compounds isolated from Salvia plebeia[J]. Food Chemistry, 2000, 71 4: Pages 489-493. DOI: 10.1016/s0308-8146(00)00191-6
[2] JEN-WAI CHAI. Gene regulation in β-sitosterol-mediated stimulation of adipogenesis, glucose uptake, and lipid mobilization in rat primary adipocytes.[J]. Genes & Nutrition, 2011, 6 2: 181-188. DOI: 10.1007/s12263-010-0196-4
[3] EVAN HADRIAN. Steroids from Atactodea striata and Their Cytotoxic Activity against MCF-7 Breast Cancer Cell Lines[J]. Indonesian Journal of Chemistry, 2022. DOI: 10.22146/ijc.76438
[4] JIANFENG XU Tiantian L Lei Yang. β-sitosterol targets glucocorticoid receptor to reduce airway inflammation and remodeling in allergic asthma[J]. Pulmonary pharmacology & therapeutics, 2023, 78: Article 102183. DOI: 10.1016/j.pupt.2022.102183
[5] I IKEDA. Antihypercholesterolemic activity of beta-sitostanol in rabbits.[J]. Journal of nutritional science and vitaminology, 1981, 27 3: 243-251. DOI: 10.3177/jnsv.27.243
[6] AYOUB MEDJMEDJ. In Cellulo and In Vivo Comparison of Cholesterol, Beta-Sitosterol and Dioleylphosphatidylethanolamine for Lipid Nanoparticle Formulation of mRNA.[J]. Nanomaterials, 2022. DOI: 10.3390/nano12142446

beta-Sitosterol Preparation Products And Raw materials

Raw materials

Enamel reaction vessel 1-(2,5-dichlorophenyl)-3-pivaloyamido-4-(2-butyloxy-5-tertoctyl phenyl)mercapto-5-phrazolone RICE BRAN OIL

Preparation Products

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beta-Sitosterol Suppliers

Belgium 4 Canada 4 CHINA 629 Czech Republic 1 Europe 3 France 5 Germany 10 India 11 Japan 5 Norway 1 Poland 1 Russia 1 Spain 1 Switzerland 3 The Netherlands 2 United Kingdom 14 United States 78 USA 1 Global 775

Xi'an Kono chem co., Ltd.

Tel: 029-84385017-8006 15891391030
Email: info@konochemical.com
Country: China
ProdList: 643
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Nanning Saifir Biotechnology Co., Ltd.

Tel: 18877121284
Email: 1309367106@qq.com
Country: China
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Shandong Tangzheng Biotechnology Co., Ltd

Tel: 15318846974
Email: 3999356010@qq.com
Country: China
ProdList: 497
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SiChuan HHTC Biological Technology Co., LTD

Tel: 15982498737
Email: 85819125@qq.com
Country: China
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Hubei Hengluyuan Technology co.ltd

Tel: 027-88188016 18717196322
Email: 1764683941@qq.com
Country: China
ProdList: 6556
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J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
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Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
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INTATRADE GmbH

Tel: +49 3493/605464
Fax: +49 3493/605470
Email: sales@intatrade.de
Country: Germany
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3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
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Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
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View Lastest Price from beta-Sitosterol manufacturers

BINBO BIOLOGICAL CO.,LTD

Product: Beta-Sitosterol 83-46-5
Price: US $0.00/kg
Min. Order: 1kg
Purity: 60%、70%、80%、90%
Supply Ability: 1000 kg
Release date: 2025-11-27

WUHAN FORTUNA CHEMICAL CO., LTD

Product: beta-Sitosterol 83-46-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 80% β-Sitosterol
Supply Ability: 100KGS
Release date: 2025-09-28

Wuhan JiyunZen Tech Co., Ltd.

Product: Beta-Sitosterol 83-46-5
Price: US $5.00-0.50/KG
Min. Order: 1KG
Purity: 99% hplc
Supply Ability: 500TONS
Release date: 2025-05-08

83-46-5, beta-SitosterolRelated Search:

STIGMASTEROL Diethylstilbestrol Lactobacillus plantarum Phytosphingosine phytosphingosine [2R[2R*(4R*,8R*)]]-3,4-dihydro-2,5,8-trimethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-ol methyl (16alpha,17beta)-17-hydroxyyohimban-16-carboxylate D-beta- Tocotrienol zhiwuyousuan Phytate Fatty acids, C10-20 and C16-18-unsatd., reaction products with triethanolamine, di-Me sulfate-quaternized PEG-25 PHYTOSTEROL PHYTOSTEROLS LUMISTEROL BETA-SITOSTEROL ACETATE PLANT STEROL MIX,PLANT STEROL MIXTURE Cholesterol 5α-Sitosterol,α1-Sitosterol

B-SITOSTEROL

5-STIGMASTEN-3BETA-OL

22,23-DIHYDROSTIMASTEROL

22,23-DIHYDROSTIGMASTEROL

24-ALPHA-ETHYLCHOLESTEROL

24BETA-ETHYLCHOLESTEROL

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PHYTOSTEROL

SITOSTEROLS

SITOSTEROL, B-

SITOSTEARIN

SITOSTEROL

(3.beta.)-Stigmast-5-en-3-ol

(3-beta)-stigmast-5-en-3-o

(3beta)-stigmast-5-en-3-o

Angelicin (steroid)

angelicin(steroid)

azuprostat

beta-Sitosterin

Cupreol

delta5-stigmasten-3-beta-ol

DELTA5-Stigmasten-3beta-ol

Harzol

β-Sitosterol, >40.0%(GC)

β-Sitosterol, >75.0%(GC)

α-Dihydrofucosterol, 22,23-Dihydrostigmasterol, 24β-Ethylcholesterol, 5-Stigmasten-3β-ol

β-Sitosterd

(3β)-stigmast-5-en-3-ol

24β-ethyl-Δ5-cholesten-3β-ol

cytellin

prostasal

stigmast-6-en-3β-ol

β-sitosterin

Δ5-stigmasten-3β-ol

SITOSTENONE, BETA-(P)(PLEASE CALL)

β-Sitosterol ,98%

β-Sitosterol,α-Dihydrofucosterol, 22,23-Dihydrostigmasterol, 24β-Ethylcholesterol, 5-Stigmasten-3β-ol

Beta-Sitosterol (300 mg)

Beta-Sitosterol (300 mg)F0D2170.98mg/mg(an)

β-Sitosteol

b-Sitosterol - min 70%

(contains CaMpesterol)

beta-Sitosterol&nbsp

Flemun

Cholest-5-en-24-ethyl-3beta-ol

beta-Sitosterol, with ca. 10% caMpesterol, ca. 75% beta-sitosterol 100GR

beta-Sitosterol, with ca. 10% caMpesterol, ca. 75% beta-sitosterol 5GR

(24R)-Ethylcholest-5-en-3β-ol

(24R)-StigMast-5-en-3β-ol

Bata-Sitosterol

nimbosterol

Quebrachol