beta-Sitosterol

Product Name: beta-Sitosterol
CAS No.: 83-46-5
Chemical Name: beta-Sitosterol
Synonyms: β-Sitosterol;SITOSTEROL;PHYTOSTEROL;B-SITOSTEROL;22,23-DIHYDROSTIGMASTEROL;Sterol;Stigmast-5-en-3beta-ol;sobatum;Quebrachol;nimbosterol
CBNumber: CB4345688
Molecular Formula: C29H50O
Formula Weight: 414.72
MOL File: 83-46-5.mol

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beta-Sitosterol Property

Melting point:: 136-140 °C(lit.)
alpha: -28 º (c=2, CHCl3)
Boiling point:: 473.52°C (rough estimate)
Density: 0.9540 (rough estimate)
refractive index: 1.5000 (estimate)
storage temp.: 2-8°C
solubility: chloroform: 20 mg/mL, clear, colorless
form: White solid
pka: 15.03±0.70(Predicted)
color: White to Off-White
optical activity: -3725 (c 2, CHCl3)
Water Solubility: INSOLUBLE
Merck: 14,8556
BRN: 1916165
InChIKey: KZJWDPNRJALLNS-VJSFXXLFSA-N
LogP: 10.482 (est)
CAS DataBase Reference: 83-46-5(CAS DataBase Reference)
NIST Chemistry Reference: «beta»-Sitosterol(83-46-5)
EPA Substance Registry System: .beta.-Sitosterol (83-46-5)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-38-40-48/20/22-36/37/38-67-36/38-20-63
Safety Statements: 22-24/25-36-26-36/37
RIDADR: UN 1888 6.1/PG 3
WGK Germany: 3
RTECS: WJ2600000
F: 10
HS Code: 29061990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

H336May cause drowsiness or dizziness

H351Suspected of causing cancer

H372Causes damage to organs through prolonged or repeated exposure

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P273Avoid release to the environment.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR2693
Product name: β-Sitosterol
Purity: Pharmaceutical Secondary Standard; Certified Reference Material, certified reference material, pharmaceutical secondary standard, pkg of 200?mg
Packaging: 200MG
Price: $292
Updated: 2024/03/01

Sigma-Aldrich

Product number: PHL89283
Product name: β-Sitosterol
Purity: phyproof? Reference Substance
Packaging: 25MG
Price: $377
Updated: 2024/03/01

Sigma-Aldrich

Product number: 567152
Product name: β-Sitosterol - CAS 83-46-5 - Calbiochem
Purity: Common plant steroid that possesses anticholesteremic properties.
Packaging: 5G
Price: $54.7
Updated: 2024/03/01

Sigma-Aldrich

Product number: 567152
Product name: β-Sitosterol - CAS 83-46-5 - Calbiochem
Purity: Common plant steroid that possesses anticholesteremic properties.
Packaging: 25G
Price: $239
Updated: 2024/03/01

Sigma-Aldrich

Product number: 47133
Product name: β-Sitosterol
Purity: certified reference material, 100?μg/mL in chloroform
Packaging: 1mL
Price: $45.5
Updated: 2024/03/01

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beta-Sitosterol Chemical Properties,Usage,Production

Description

24α-ethyl Cholesterol is a naturally occurring plant sterol with antioxidant, anticancer, anti-inflammatory, angiogenic, chemopreventive, and immunomodulatory activities. It inhibits the absorption of dietary and endogenously-produced cholesterol from the small intestine, reducing blood cholesterol concentrations. Because of its nutraceutical benefits, 24α-ethyl cholesterol has been used as a food additive intended to lower LDL cholesterol. 24α-ethyl Cholesterol (0.1 - 100 μM) can dose-dependently induce adipogenesis and lipolysis in rat primary preadipocytes as well as stimulate glucose uptake in differentiated adipocytes.

Chemical Properties

White powder

Uses

antiinflammatory, immunomodulator

Uses

A common sterol in plants. Isolated from wheat germ oil, corn oil. Antilipemic. Used in the treatment of prostatic adenoma.This compound is a contaminant of emerging concern (CECs)

Definition

A steroid with long aliphatic side chains (8–10 carbons) and at least one hydroxyl group. They are lipidsoluble and often occur in membranes. Examples are cholesterol and ergosterol.

Definition

sterol: Any of a group of steroidbasedalcohols having a hydrocarbonside-chain of 8–10 carbon atoms.Sterols exist either as free sterols oras esters of fatty acids. Animal sterols(zoosterols) include cholesterol andlanosterol. The major plant sterol(phytosterol) is beta-sitosterol, whilefungal sterols (mycosterols) includeergosterol.

Definition

ChEBI: A phytosterols that is stigmast-5-ene substituted by a beta-hydroxy group at position 3.

General Description

Sitosterol, also called as β-sitosterol, is synthesized through the mevalonate and deoxy xylulose pathways. Synthetically, it is synthesized from stigmasterol by Δ22–23 alkene group hydrogenation. Structurally sitosterol differ from cholesterol with ethyl (sitosterol) group in C24 position of side chain(65). Sitosterol is a lipid component of membranes. It corresponds to a molecular mass of 414.71 g/mol).

Biochem/physiol Actions

Sitosterol promotes the antioxidant levels and is used as an effective anti-inflammatory, antiapoptotic and anticancer agent in medicinal preparations. It acts as a neutralizing agent for the venom from viper and cobra. Sitosterol acts on protein kinase C (PKC) and in the sphingomyelin cycle to mediate tumor progression inhibition.

Purification Methods

Crystallise -sitosterol from EtOH, MeOH, Me2CO, Me2CO/EtOH or Me2CO/MeOH. It has also been purified by zone melting. The acetate crystallises from MeOH or EtOH as plates with m 127128o and [] D 20 -41o (c 2, CHCl3). The benzoate crystallises from EtOH as needles with m 146-147o and [] D 20 –13.8o (c 2, CHCl3). [Fujimoto & Jacobson J Org Chem 29 3377, 3381 1964, Shoppee J Chem Soc 10431948, Heilbron et al. J Chem Soc 344, 347 1941, Beilstein 6 III 2696.]

beta-Sitosterol Preparation Products And Raw materials

Raw materials

Enamel reaction vessel 1-(2,5-dichlorophenyl)-3-pivaloyamido-4-(2-butyloxy-5-tertoctyl phenyl)mercapto-5-phrazolone RICE BRAN OIL

Preparation Products

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beta-Sitosterol Suppliers

Belgium 4 Canada 4 China 534 Czech Republic 1 Europe 3 France 5 Germany 10 India 11 Japan 5 Norway 1 Poland 1 Russia 1 Spain 1 Switzerland 3 The Netherlands 2 United Kingdom 14 United States 77 USA 1 Global 679

INTATRADE GmbH

Tel: +49 3493/605464
Fax: +49 3493/605470
Email: sales@intatrade.de
Country: Germany
ProdList: 3572
Advantage: 66

TransMIT GmbH PlantMetaChem

Tel: +49-172-1024293
Fax: +49-(0)6422-938149
Email: pmc@transmit.de
Country: Germany
ProdList: 142
Advantage: 60

AREVIPHARMA GMBH

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Email: dirk.jung@arevipharma.com
Country: Germany
ProdList: 23
Advantage: 58

CHEMOS GmbH & Co. KG

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Email: chemos@chemos.de
Country: Germany
ProdList: 6727
Advantage: 58

ChemPur GmbH

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Country: Germany
ProdList: 2737
Advantage: 50

ABCR GmbH & CO. KG

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Country: Germany
ProdList: 6831
Advantage: 75

Service Chemical Inc.

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ProdList: 6350
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AppliChem GmbH

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ProdList: 1607
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BIOTREND Chemikalien GmbH

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ProdList: 6115
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cfm Oskar Tropitzsch

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ProdList: 1136
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View Lastest Price from beta-Sitosterol manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

Product: beta-Sitosterol 83-46-5
Price: US $100.00-75.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000Ton
Release date: 2024-08-09

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: beta-Sitosterol 83-46-5
Price: US $20.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000kg/Week
Release date: 2024-05-06

WUHAN FORTUNA CHEMICAL CO., LTD

Product: beta-Sitosterol 83-46-5
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 80% β-Sitosterol
Supply Ability: 100KGS
Release date: 2021-06-30

83-46-5, beta-SitosterolRelated Search:

STIGMASTEROL Diethylstilbestrol Lactobacillus plantarum Phytosphingosine phytosphingosine [2R[2R*(4R*,8R*)]]-3,4-dihydro-2,5,8-trimethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-ol methyl (16alpha,17beta)-17-hydroxyyohimban-16-carboxylate D-beta- Tocotrienol zhiwuyousuan Phytate Fatty acids, C10-20 and C16-18-unsatd., reaction products with triethanolamine, di-Me sulfate-quaternized PEG-25 PHYTOSTEROL PHYTOSTEROLS LUMISTEROL BETA-SITOSTEROL ACETATE PLANT STEROL MIX,PLANT STEROL MIXTURE sterol Cholesterin,Cholest-5-en-3beta-ol 5α-Sitosterol,α1-Sitosterol

B-SITOSTEROL

5-STIGMASTEN-3BETA-OL

22,23-DIHYDROSTIMASTEROL

22,23-DIHYDROSTIGMASTEROL

24-ALPHA-ETHYLCHOLESTEROL

24BETA-ETHYLCHOLESTEROL

5-CHOLESTEN-24-BETA-ETHYL-3-BETA-OL

(3)-BETA-SITOSTEROL(2)

ALPHA-DIHYDROFUCOSTEROL

ALPHA-PHYTOSTEROL

BETA-SITOSTEROL

A-PHYTOSTEROL

CINCHOL

PHYTOSTEROL

SITOSTEROLS

SITOSTEROL, B-

SITOSTEARIN

SITOSTEROL

(3.beta.)-Stigmast-5-en-3-ol

(3-beta)-stigmast-5-en-3-o

(3beta)-stigmast-5-en-3-o

Angelicin (steroid)

angelicin(steroid)

azuprostat

beta-Sitosterin

Cupreol

delta5-stigmasten-3-beta-ol

DELTA5-Stigmasten-3beta-ol

Harzol

β-Sitosterol, >40.0%(GC)

β-Sitosterol, >75.0%(GC)

α-Dihydrofucosterol, 22,23-Dihydrostigmasterol, 24β-Ethylcholesterol, 5-Stigmasten-3β-ol

β-Sitosterd

(3β)-stigmast-5-en-3-ol

24β-ethyl-Δ5-cholesten-3β-ol

cytellin

prostasal

stigmast-6-en-3β-ol

β-sitosterin

Δ5-stigmasten-3β-ol

SITOSTENONE, BETA-(P)(PLEASE CALL)

β-Sitosterol ,98%

β-Sitosterol,α-Dihydrofucosterol, 22,23-Dihydrostigmasterol, 24β-Ethylcholesterol, 5-Stigmasten-3β-ol

Beta-Sitosterol (300 mg)

Beta-Sitosterol (300 mg)F0D2170.98mg/mg(an)

β-Sitosteol

b-Sitosterol - min 70%

(contains CaMpesterol)

beta-Sitosterol&nbsp

Flemun

Cholest-5-en-24-ethyl-3beta-ol

beta-Sitosterol, with ca. 10% caMpesterol, ca. 75% beta-sitosterol 100GR

beta-Sitosterol, with ca. 10% caMpesterol, ca. 75% beta-sitosterol 5GR

(24R)-Ethylcholest-5-en-3β-ol

(24R)-StigMast-5-en-3β-ol

Bata-Sitosterol

nimbosterol

Quebrachol