ChemicalBook > CAS DataBase List > beta-Sitosterol

beta-Sitosterol

Product Name
beta-Sitosterol
CAS No.
83-46-5
Chemical Name
beta-Sitosterol
Synonyms
β-Sitosterol;SITOSTEROL;PHYTOSTEROL;B-SITOSTEROL;22,23-DIHYDROSTIGMASTEROL;Sterol;Stigmast-5-en-3beta-ol;sobatum;Quebrachol;nimbosterol
CBNumber
CB4345688
Molecular Formula
C29H50O
Formula Weight
414.72
MOL File
83-46-5.mol
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beta-Sitosterol Property

Melting point:
136-140 °C(lit.)
alpha 
-28 º (c=2, CHCl3)
Boiling point:
473.52°C (rough estimate)
Density 
0.9540 (rough estimate)
refractive index 
1.5000 (estimate)
storage temp. 
2-8°C
solubility 
chloroform: 20 mg/mL, clear, colorless
form 
White solid
pka
15.03±0.70(Predicted)
color 
White to Off-White
Water Solubility 
INSOLUBLE
Merck 
14,8556
BRN 
1916165
InChIKey
KZJWDPNRJALLNS-VJSFXXLFSA-N
LogP
10.482 (est)
CAS DataBase Reference
83-46-5(CAS DataBase Reference)
NIST Chemistry Reference
«beta»-Sitosterol(83-46-5)
EPA Substance Registry System
.beta.-Sitosterol (83-46-5)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-38-40-48/20/22-36/37/38-67-36/38-20-63
Safety Statements 
22-24/25-36-26-36/37
RIDADR 
UN 1888 6.1/PG 3
WGK Germany 
3
RTECS 
WJ2600000
F 
10
HS Code 
29061990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

H336May cause drowsiness or dizziness

H351Suspected of causing cancer

H372Causes damage to organs through prolonged or repeated exposure

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P273Avoid release to the environment.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR2693
Product name
β-Sitosterol
Purity
Pharmaceutical Secondary Standard; Certified Reference Material, certified reference material, pharmaceutical secondary standard, pkg of 200?mg
Packaging
200MG
Price
$292
Updated
2024/03/01
Sigma-Aldrich
Product number
PHL89283
Product name
β-Sitosterol
Purity
phyproof? Reference Substance
Packaging
25MG
Price
$377
Updated
2024/03/01
Sigma-Aldrich
Product number
567152
Product name
β-Sitosterol - CAS 83-46-5 - Calbiochem
Purity
Common plant steroid that possesses anticholesteremic properties.
Packaging
5G
Price
$54.7
Updated
2024/03/01
Sigma-Aldrich
Product number
567152
Product name
β-Sitosterol - CAS 83-46-5 - Calbiochem
Purity
Common plant steroid that possesses anticholesteremic properties.
Packaging
25G
Price
$239
Updated
2024/03/01
Sigma-Aldrich
Product number
47133
Product name
β-Sitosterol
Purity
certified reference material, 100?μg/mL in chloroform
Packaging
1mL
Price
$45.5
Updated
2024/03/01
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beta-Sitosterol Chemical Properties,Usage,Production

Description

24α-ethyl Cholesterol is a naturally occurring plant sterol with antioxidant, anticancer, anti-inflammatory, angiogenic, chemopreventive, and immunomodulatory activities. It inhibits the absorption of dietary and endogenously-produced cholesterol from the small intestine, reducing blood cholesterol concentrations. Because of its nutraceutical benefits, 24α-ethyl cholesterol has been used as a food additive intended to lower LDL cholesterol. 24α-ethyl Cholesterol (0.1 - 100 μM) can dose-dependently induce adipogenesis and lipolysis in rat primary preadipocytes as well as stimulate glucose uptake in differentiated adipocytes.

Chemical Properties

White powder

Uses

antiinflammatory, immunomodulator

Uses

A common sterol in plants. Isolated from wheat germ oil, corn oil. Antilipemic. Used in the treatment of prostatic adenoma.This compound is a contaminant of emerging concern (CECs)

Definition

A steroid with long aliphatic side chains (8–10 carbons) and at least one hydroxyl group. They are lipidsoluble and often occur in membranes. Examples are cholesterol and ergosterol.

Definition

sterol: Any of a group of steroidbasedalcohols having a hydrocarbonside-chain of 8–10 carbon atoms.Sterols exist either as free sterols oras esters of fatty acids. Animal sterols(zoosterols) include cholesterol andlanosterol. The major plant sterol(phytosterol) is beta-sitosterol, whilefungal sterols (mycosterols) includeergosterol.

Definition

ChEBI: A phytosterols that is stigmast-5-ene substituted by a beta-hydroxy group at position 3.

General Description

Sitosterol, also called as β-sitosterol, is synthesized through the mevalonate and deoxy xylulose pathways. Synthetically, it is synthesized from stigmasterol by Δ22–23 alkene group hydrogenation. Structurally sitosterol differ from cholesterol with ethyl (sitosterol) group in C24 position of side chain(65). Sitosterol is a lipid component of membranes. It corresponds to a molecular mass of 414.71 g/mol).

Biochem/physiol Actions

Sitosterol promotes the antioxidant levels and is used as an effective anti-inflammatory, antiapoptotic and anticancer agent in medicinal preparations. It acts as a neutralizing agent for the venom from viper and cobra. Sitosterol acts on protein kinase C (PKC) and in the sphingomyelin cycle to mediate tumor progression inhibition.

Purification Methods

Crystallise -sitosterol from EtOH, MeOH, Me2CO, Me2CO/EtOH or Me2CO/MeOH. It has also been purified by zone melting. The acetate crystallises from MeOH or EtOH as plates with m 127128o and [] D 20 -41o (c 2, CHCl3). The benzoate crystallises from EtOH as needles with m 146-147o and [] D 20 –13.8o (c 2, CHCl3). [Fujimoto & Jacobson J Org Chem 29 3377, 3381 1964, Shoppee J Chem Soc 10431948, Heilbron et al. J Chem Soc 344, 347 1941, Beilstein 6 III 2696.]

beta-Sitosterol Preparation Products And Raw materials

Raw materials

Enamel reaction vessel 1-(2,5-dichlorophenyl)-3-pivaloyamido-4-(2-butyloxy-5-tertoctyl phenyl)mercapto-5-phrazolone RICE BRAN OIL

Preparation Products

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View Lastest Price from beta-Sitosterol manufacturers

Hebei Kingfiner Technology Development Co.Ltd
Product
beta-Sitosterol 83-46-5
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
500000kg
Release date
2023-06-05
Shaanxi Dideu Medichem Co. Ltd
Product
beta-Sitosterol 83-46-5
Price
US $0.10/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
1000 tons
Release date
2019-12-30
Changsha Staherb Natural Ingredients Co., Ltd.
Product
beta-Sitosterol; Soybean extract 83-46-5
Price
US $0.00/KG
Min. Order
1KG
Purity
≥ 98% HPLC
Supply Ability
1000KG
Release date
2022-09-23

83-46-5, beta-SitosterolRelated Search:

STIGMASTEROL Diethylstilbestrol Lactobacillus plantarum Phytosphingosine phytosphingosine [2R[2R*(4R*,8R*)]]-3,4-dihydro-2,5,8-trimethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-ol methyl (16alpha,17beta)-17-hydroxyyohimban-16-carboxylate D-beta- Tocotrienol zhiwuyousuan Phytate Fatty acids, C10-20 and C16-18-unsatd., reaction products with triethanolamine, di-Me sulfate-quaternized PEG-25 PHYTOSTEROL PHYTOSTEROLS LUMISTEROL BETA-SITOSTEROL ACETATE PLANT STEROL MIX,PLANT STEROL MIXTURE sterol Cholesterin,Cholest-5-en-3beta-ol 5α-Sitosterol,α1-Sitosterol

  • B-SITOSTEROL
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  • 22,23-DIHYDROSTIGMASTEROL
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  • 24BETA-ETHYLCHOLESTEROL
  • 5-CHOLESTEN-24-BETA-ETHYL-3-BETA-OL
  • (3)-BETA-SITOSTEROL(2)
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  • A-PHYTOSTEROL
  • CINCHOL
  • PHYTOSTEROL
  • SITOSTEROLS
  • SITOSTEROL, B-
  • SITOSTEARIN
  • SITOSTEROL
  • (3.beta.)-Stigmast-5-en-3-ol
  • (3-beta)-stigmast-5-en-3-o
  • (3beta)-stigmast-5-en-3-o
  • Angelicin (steroid)
  • angelicin(steroid)
  • azuprostat
  • beta-Sitosterin
  • Cupreol
  • delta5-stigmasten-3-beta-ol
  • DELTA5-Stigmasten-3beta-ol
  • Harzol
  • β-Sitosterol, >40.0%(GC)
  • β-Sitosterol, >75.0%(GC)
  • α-Dihydrofucosterol, 22,23-Dihydrostigmasterol, 24β-Ethylcholesterol, 5-Stigmasten-3β-ol
  • β-Sitosterd
  • (3β)-stigmast-5-en-3-ol
  • 24β-ethyl-Δ5-cholesten-3β-ol
  • cytellin
  • prostasal
  • stigmast-6-en-3β-ol
  • β-sitosterin
  • Δ5-stigmasten-3β-ol
  • SITOSTENONE, BETA-(P)(PLEASE CALL)
  • β-Sitosterol ,98%
  • β-Sitosterol,α-Dihydrofucosterol, 22,23-Dihydrostigmasterol, 24β-Ethylcholesterol, 5-Stigmasten-3β-ol
  • Beta-Sitosterol (300 mg)
  • Beta-Sitosterol (300 mg)F0D2170.98mg/mg(an)
  • β-Sitosteol
  • b-Sitosterol - min 70%
  • (contains CaMpesterol)
  • beta-Sitosterol&nbsp
  • Flemun
  • Cholest-5-en-24-ethyl-3beta-ol
  • beta-Sitosterol, with ca. 10% caMpesterol, ca. 75% beta-sitosterol 100GR
  • beta-Sitosterol, with ca. 10% caMpesterol, ca. 75% beta-sitosterol 5GR
  • (24R)-Ethylcholest-5-en-3β-ol
  • (24R)-StigMast-5-en-3β-ol
  • Bata-Sitosterol
  • nimbosterol
  • Quebrachol