Sesamin

Product Name: Sesamin
CAS No.: 607-80-7
Chemical Name: Sesamin
Synonyms: L-Sesamin;FAGAROL;SesameP.E.;SezaMin;SESAMIN;Fsesamin;d-Sesamin;NSC 36403;AI3-00811;SESAMIN(P)
CBNumber: CB5783674
Molecular Formula: C20H18O6
Formula Weight: 354.35
MOL File: 607-80-7.mol

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Sesamin Property

Melting point:: 121.0 to 125.0 °C
Boiling point:: 504.4±50.0 °C(Predicted)
Density: 1.385±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO (>25 mg/ml)
form: crystalline
color: White
biological source: Sesamum indicum (sesame)
Merck: 14,8470
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChI: InChI=1S/C20H18O6/c1-3-15-17(25-9-23-15)5-11(1)19-13-7-22-20(14(13)8-21-19)12-2-4-16-18(6-12)26-10-24-16/h1-6,13-14,19-20H,7-10H2
InChIKey: PEYUIKBAABKQKQ-AFHBHXEDSA-N
SMILES: O1CC2C(C3=CC=C4OCOC4=C3)OCC2C1C1=CC=C2OCOC2=C1
LogP: 4.064 (est)

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
HS Code: 29329990
Storage Class: 11 - Combustible Solids
Hazard Classifications: Skin Sens. 1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SMB00705
Product name: Sesamin
Purity: ≥98% (HPLC)
Packaging: 10MG
Price: $234
Updated: 2025/07/31

Sigma-Aldrich

Product number: SMB00705
Product name: Sesamin
Purity: ≥98% (HPLC)
Packaging: 50MG
Price: $863
Updated: 2025/07/31

Sigma-Aldrich

Product number: 59867
Product name: Sesamin
Purity: analytical standard
Packaging: 10mg
Price: $236
Updated: 2025/07/31

Sigma-Aldrich

Product number: S9314
Product name: Sesamin
Purity: ≥95%, crystalline
Packaging: 5mg
Price: $436
Updated: 2022/05/15

TCI Chemical

Product number: S0495
Product name: Sesamin
Purity: >98.0%(GC)
Packaging: 100mg
Price: $362
Updated: 2025/07/31

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Sesamin Chemical Properties,Usage,Production

Description

Sesamin (607-80-7) is a natural product derived from sesame seeds with anticancer1, antioxidant2, anti-inflammatory/immunomodulatory3, and antidiabetic4,5 effects. It also displayed effects on cholesterol and fatty acid metabolism.6 Sesamin was recently found to inhibit bacterial L-tryptophan indole lyase (Ki = 7 μM).7 This enzyme reacts with dietary tryptophan to produce the uremic toxin indoxyl sulfate which exacerbates chronic kidney disease.

Chemical Properties

White powder

Uses

A lignan isolated from the bark of Fagara plants and from sesame oil. Studies show that it has has multiple functions such as cholesterol-lowering and anti-hypertensive activities. It induces the expr ession of the gene for aldehyde dehydrogenase, an alcohol-metabolizing enzyme suggesting it regulates the metabolism of lipids, xenobiotics, and alcohol at the mRNA level.

Uses

Sesamin has been used:

as a lignan to study its effects on the osteoblastic differentiation of rat bone marrow stromal cells (BMSCs)
as a standard for the isolation of sesamin from sesame oil
as an enterolignan to study its effects on the proliferation of estrogen-receptor (ER)-positive human breast cancer MCF-7 cells

Definition

ChEBI: A lignan that consists of tetrahydro-1H,3H-furo[3,4-c]furan substituted by 1,3-benzodioxole groups at positions 1 and 4 (the 1S,3aR,4S,6aR

General Description

Sesamin is a fat-soluble furfuran lignan present in Sesamum indicumL seeds.

Biochem/physiol Actions

Non-competitive Δ5-desaturase inhibitor.

Synthesis

Measure 1L of sesame oil foot (965.8g), add 4L of anhydrous ethanol, stirring at 30 for 5h, static stratification, take the upper layer of clear liquid, rotary evaporation to get sesquiterpene enriched material; to sesquiterpene enriched material to add anhydrous methanol, sesquiterpene enriched material with anhydrous methanol material-liquid ratio of 1:4 (kg/L), at 55 under the extraction of 3h, get the extract; to the extraction of the liquid to add activated carbon. Activated carbon added to the extraction solution, the amount of 1% of the mass of the extraction solution, stirring for 0.5h, and then filtered to obtain the sesquiterpene extract; the sesquiterpene extract slowly cooled down to -10 , so that the sesquiterpene crystallization, crystallization of 2h, filtration of sesquiterpene crude; to add petroleum ether to sesquiterpene crude, sesquiterpene crude and petroleum ether material-liquid ratio of 1:1 (kg/L), 35 , closed mixing for 0.5h, filtration Sesquiterpene crude product; sesquiterpene crude product dissolved in anhydrous ethanol, sesquiterpene crude product and anhydrous ethanol material-liquid ratio of 1:30 (kg / L), at -5 under the crystallization and purification, the time to maintain 3 hours, under this condition after two times crystallization, vacuum drying to obtain sesquiterpene products 2.16 g, sesquiterpene extraction rate of 89.1%, the purity of the resulting sesquiterpene products is 92.1%.

References

[1] AMIN F. MAJDALAWIEH Gheyath K N Mariam Massri. A comprehensive review on the anti-cancer properties and mechanisms of action of sesamin, a lignan in sesame seeds (Sesamum indicum)[J]. European journal of pharmacology, 2017, 815: Pages 512-521. DOI:10.1016/j.ejphar.2017.10.020
[2] KISO Y. Antioxidative roles of sesamin, a functional lignan in sesame seed, and it’s effect on lipid- and alcohol-metabolism in the liver: A DNA microarray study[J]. BioFactors, 2008, 21 1-4: 191-196. DOI:10.1002/biof.552210139
[3] AMIN F MAJDALAWIEH. Immunomodulatory and anti-inflammatory effects of sesamin: mechanisms of action and future directions.[J]. Critical reviews in food science and nutrition, 2022, 62 18: 5081-5112. DOI:10.1080/10408398.2021.1881438
[4] MAJID MOHAMMAD SHAHI. Effect of Sesamin Supplementation on Glycemic Status, Inflammatory Markers, and Adiponectin Levels in Patients with Type 2 Diabetes Mellitus.[J]. Journal of Dietary Supplements, 2017, 14 1: 65-75. DOI:10.1080/19390211.2016.1204404
[5] YAGHOOB FARBOOD . Sesamin: A promising protective agent against diabetes-associated cognitive decline in rats[J]. Life sciences, 2019, 230: Pages 169-177. DOI:10.1016/j.lfs.2019.05.071
[6] AMIN F. MAJDALAWIEH Sarah M Y Sarah Dalibalta. Effects of sesamin on fatty acid and cholesterol metabolism, macrophage cholesterol homeostasis and serum lipid profile: A comprehensive review[J]. European journal of pharmacology, 2020, 885: Article 173417. DOI:10.1016/j.ejphar.2020.173417
[7] DAIKI OIKAWA . (+)-Sesamin, a sesame lignan, is a potent inhibitor of gut bacterial tryptophan indole-lyase that is a key enzyme in chronic kidney disease pathogenesis[J]. Biochemical and biophysical research communications, 2022, 590: Pages 158-162. DOI:10.1016/j.bbrc.2021.12.088

Sesamin Preparation Products And Raw materials

Raw materials

Preparation Products

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Sesamin Suppliers

Canada 1 China 406 Czech Republic 1 Europe 2 Germany 4 India 7 Japan 1 New Zealand 2 Switzerland 1 United Kingdom 6 United States 43 USA 1 Global 475

Nanjing bingcheng Biotechnology Co., Ltd.

Tel: 18805194892
Email: 2727751293@qq.com
Country: China
ProdList: 171
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

INTATRADE GmbH

Tel: +49 3493/605464
Fax: +49 3493/605470
Email: sales@intatrade.de
Country: Germany
ProdList: 3572
Advantage: 66

future industrial shanghai co., ltd

Tel: 400-0066400 13621662912
Fax: 021-55660885
Email: sales@jonln.com
Country: China
ProdList: 1995
Advantage: 65

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
Advantage: 61

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Beijing HwrkChemical Technology Co., Ltd

Tel: 010-89508211 18501085097
Fax: 010-89508210
Email: sales.bj@hwrkchemical.com
Country: China
ProdList: 9411
Advantage: 55

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44802
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Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

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View Lastest Price from Sesamin manufacturers

Lianyungang Kaiyu Environmental Tech Co., Ltd.

Product: Sesamin 607-80-7
Price: US $1200.00-1100.00/ton
Min. Order: 1ton
Purity: 99%
Supply Ability: 1000T/M
Release date: 2025-09-30

Shaanxi Xianhe Biotech Co., Ltd

Product: Sesamin 607-80-7
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 1000kg
Release date: 2025-04-27

Hebei Zhuanglai Chemical Trading Co Ltd

Product: Sesamin 607-80-7
Price: US $150.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 500kg
Release date: 2024-12-11

607-80-7, SesaminRelated Search:

Anemarrhena Rhizome Extract GardeniaBlue Sesamol SESAMOLIN Sesame Oil CROCEIN ORANGE G Lipopolysaccharides Chlorphenamine maleate (+)-Bicuculline Doxazosin mesylate Veliparib Adenine BEZ235 (NVP-BEZ235, Dactolisib) Sophoricoside Quercetin dihydrate Rotundine pseudoprototimosaponin AIII Spirostan-3-ol

[1S-(1BETA,3ALPHA-BETA,4BETA,6ALPHA-BETA)]-5,5'-(TETRAHYDRO-1H,3H-FURO[3,4-C]FURAN-1,4-DIYL)BIS-1,3-BENZODIOXOLE

SesameP.E.

Sesamine70%

SESAMIN(P)

SESAMIN(RG)

1,3-Benzodioxole,5,5'-(tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl)bis-,[1S-(1α,3aα,4α, 6aα)]-

1,3-Benzodioxole, 5,5'-(tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl)bis-, [1S-(1a,3aa,4a,6aa)]-

Tetrahydro-1,4-bis[3,4-(methylenedioxy)phenyl]-1H,3H-furo[3,4-c]furan

(+)-5,5'-[(1S,3aβ,4S,6aβ)-Tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl]-bis-1,3-benzodioxole

(+)-5,5'-[(1S,3aβ,4β,6aβ)-Tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl]bis(1,3-benzodioxole)

d-Sesamin

Pseudocubebin

SesaMin(Fagarol)

NSC 36403

SezaMin

(1S,3aR,4S,6aR)-5,5'-(Tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl)bis-1,3-benzodioxole

3-(1,3-benzodioxol-5-yl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-6-ol

(1S,3aR,4S,6aR)-Tetrahydro-1,4-bis[3,4-(Methylenedioxy)phenyl]-1H,3H-Furo[3,4-c]furan

[1S-(1α,3aα,4α,6aα)]-5,5'-(Tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl)bis-1,3-benzodioxole

SESAMIN

FAGAROL

SesaMin, froM SesaMuM indicuM

1,3-Benzodioxole,5,5'-(tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl)bis-, (1S,3aR,4S,6aR)-

Fsesamin

L-Sesamin

Sesamin, >=98%

Sesamin, 98%, from Sesamum indicum

Sesamin&gt

Sesamin USP/EP/BP

Jujube powder

Sesame Extract, Sesamin

5-[(3S,3aR,6S,6aR)-3-(1,3-benzodioxol-5-yl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-6-yl]-1,3-benzodioxole

(1S,3aR,4S,6aR)-1,4-Bis(benzo[d][1,3]dioxol-5-yl)hexahydrofuro[3,4-c]furan

Sesamin (Fagarol, Fsesamin)

Sesamin, ≥95%

TIANFU-CHEM -Sesamin

(+)-sesamin

Sesamin powder

Sesame Extract (Sesamin 90%)

Natural Sesamin Powder

AI3-00811

Sesamin-RM

Abametapir Impurity 28

Sesamin CRS

(1S,3a-R,4S,6a-R)-1,4-bis(benzenebenzo[d][1,3]dioxypentylcyclo-5-yl)hexahydrofuranbenzo[3,4-c]furan

607-80-7

C20H15O5

C20H18O6

BioChemical

Biochemicals and Reagents

D to K

Enzyme Inhibitors by Enzyme

Enzyme Inhibitors

Enzymes, Inhibitors, and Substrates

D5-Desaturase

Aromatics

Heterocycles

Intermediates & Fine Chemicals