ChemicalBook > CAS DataBase List > Sesamin

Sesamin

Product Name: Sesamin
CAS No.: 607-80-7
Chemical Name: Sesamin
Synonyms: L-Sesamin;FAGAROL;SesameP.E.;SezaMin;SESAMIN;Fsesamin;d-Sesamin;NSC 36403;AI3-00811;SESAMIN(P)
CBNumber: CB5783674
Molecular Formula: C20H18O6
Formula Weight: 354.35
MOL File: 607-80-7.mol

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Sesamin Property

Melting point:: 121.0 to 125.0 °C
Boiling point:: 504.4±50.0 °C(Predicted)
Density: 1.385±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO (>25 mg/ml)
form: crystalline
color: White
biological source: Sesamum indicum (sesame)
Merck: 14,8470
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChI: InChI=1S/C20H18O6/c1-3-15-17(25-9-23-15)5-11(1)19-13-7-22-20(14(13)8-21-19)12-2-4-16-18(6-12)26-10-24-16/h1-6,13-14,19-20H,7-10H2
InChIKey: PEYUIKBAABKQKQ-AFHBHXEDSA-N
SMILES: O1CC2C(C3=CC=C4OCOC4=C3)OCC2C1C1=CC=C2OCOC2=C1
LogP: 4.064 (est)

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
HS Code: 29329990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SMB00705
Product name: Sesamin
Purity: ≥98% (HPLC)
Packaging: 10MG
Price: $234
Updated: 2025/07/31

Sigma-Aldrich

Product number: SMB00705
Product name: Sesamin
Purity: ≥98% (HPLC)
Packaging: 50MG
Price: $863
Updated: 2025/07/31

Sigma-Aldrich

Product number: 59867
Product name: Sesamin
Purity: analytical standard
Packaging: 10mg
Price: $236
Updated: 2025/07/31

Sigma-Aldrich

Product number: S9314
Product name: Sesamin
Purity: ≥95%, crystalline
Packaging: 5mg
Price: $436
Updated: 2022/05/15

TCI Chemical

Product number: S0495
Product name: Sesamin
Purity: >98.0%(GC)
Packaging: 100mg
Price: $362
Updated: 2025/07/31

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Sesamin Chemical Properties,Usage,Production

Description

Sesamin (607-80-7) is a natural product derived from sesame seeds with anticancer1, antioxidant2, anti-inflammatory/immunomodulatory3, and antidiabetic4,5 effects. It also displayed effects on cholesterol and fatty acid metabolism.6? Sesamin was recently found to inhibit bacterial L-tryptophan indole lyase (Ki = 7 μM).7 This enzyme reacts with dietary tryptophan to produce the uremic toxin indoxyl sulfate which exacerbates chronic kidney disease.

Chemical Properties

White powder

Uses

A lignan isolated from the bark of Fagara plants and from sesame oil. Studies show that it has has multiple functions such as cholesterol-lowering and anti-hypertensive activities. It induces the expr ession of the gene for aldehyde dehydrogenase, an alcohol-metabolizing enzyme suggesting it regulates the metabolism of lipids, xenobiotics, and alcohol at the mRNA level.

Uses

Sesamin has been used:

as a lignan to study its effects on the osteoblastic differentiation of rat bone marrow stromal cells (BMSCs)
as a standard for the isolation of sesamin from sesame oil
as an enterolignan to study its effects on the proliferation of estrogen-receptor (ER)-positive human breast cancer MCF-7 cells

Definition

ChEBI: A lignan that consists of tetrahydro-1H,3H-furo[3,4-c]furan substituted by 1,3-benzodioxole groups at positions 1 and 4 (the 1S,3aR,4S,6aR

General Description

Sesamin is a fat-soluble furfuran lignan present in Sesamum indicum?L seeds.

Biochem/physiol Actions

Non-competitive Δ5-desaturase inhibitor.

References

[1] AMIN F. MAJDALAWIEH Gheyath K N Mariam Massri. A comprehensive review on the anti-cancer properties and mechanisms of action of sesamin, a lignan in sesame seeds (Sesamum indicum)[J]. European journal of pharmacology, 2017, 815: Pages 512-521. DOI:10.1016/j.ejphar.2017.10.020
[2] KISO Y. Antioxidative roles of sesamin, a functional lignan in sesame seed, and it’s effect on lipid- and alcohol-metabolism in the liver: A DNA microarray study[J]. BioFactors, 2008, 21 1-4: 191-196. DOI:10.1002/biof.552210139
[3] AMIN F MAJDALAWIEH. Immunomodulatory and anti-inflammatory effects of sesamin: mechanisms of action and future directions.[J]. Critical reviews in food science and nutrition, 2022, 62 18: 5081-5112. DOI:10.1080/10408398.2021.1881438
[4] MAJID MOHAMMAD SHAHI. Effect of Sesamin Supplementation on Glycemic Status, Inflammatory Markers, and Adiponectin Levels in Patients with Type 2 Diabetes Mellitus.[J]. Journal of Dietary Supplements, 2017, 14 1: 65-75. DOI:10.1080/19390211.2016.1204404
[5] YAGHOOB FARBOOD . Sesamin: A promising protective agent against diabetes-associated cognitive decline in rats[J]. Life sciences, 2019, 230: Pages 169-177. DOI:10.1016/j.lfs.2019.05.071
[6] AMIN F. MAJDALAWIEH Sarah M Y Sarah Dalibalta. Effects of sesamin on fatty acid and cholesterol metabolism, macrophage cholesterol homeostasis and serum lipid profile: A comprehensive review[J]. European journal of pharmacology, 2020, 885: Article 173417. DOI:10.1016/j.ejphar.2020.173417
[7] DAIKI OIKAWA . (+)-Sesamin, a sesame lignan, is a potent inhibitor of gut bacterial tryptophan indole-lyase that is a key enzyme in chronic kidney disease pathogenesis[J]. Biochemical and biophysical research communications, 2022, 590: Pages 158-162. DOI:10.1016/j.bbrc.2021.12.088

Sesamin Preparation Products And Raw materials

Raw materials

Preparation Products

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Sesamin Suppliers

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View Lastest Price from Sesamin manufacturers

Lianyungang Kaiyu Environmental Tech Co., Ltd.

Product: Sesamin 607-80-7
Price: US $1200.00-1100.00/ton
Min. Order: 1ton
Purity: 99%
Supply Ability: 1000T/M
Release date: 2025-09-30

Shaanxi Xianhe Biotech Co., Ltd

Product: Sesamin 607-80-7
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 1000kg
Release date: 2025-04-27

Hebei Zhuanglai Chemical Trading Co Ltd

Product: Sesamin 607-80-7
Price: US $150.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 500kg
Release date: 2024-12-11

607-80-7, SesaminRelated Search:

Anemarrhena Rhizome Extract GardeniaBlue Sesamol SESAMOLIN Sesame Oil CROCEIN ORANGE G Lipopolysaccharides Chlorphenamine maleate (+)-Bicuculline Doxazosin mesylate Veliparib Adenine BEZ235 (NVP-BEZ235, Dactolisib) Sophoricoside Quercetin dihydrate Rotundine pseudoprototimosaponin AIII Spirostan-3-ol

[1S-(1BETA,3ALPHA-BETA,4BETA,6ALPHA-BETA)]-5,5'-(TETRAHYDRO-1H,3H-FURO[3,4-C]FURAN-1,4-DIYL)BIS-1,3-BENZODIOXOLE

SesameP.E.

Sesamine70%

SESAMIN(P)

SESAMIN(RG)

1,3-Benzodioxole,5,5'-(tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl)bis-,[1S-(1α,3aα,4α, 6aα)]-

1,3-Benzodioxole, 5,5'-(tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl)bis-, [1S-(1a,3aa,4a,6aa)]-

Tetrahydro-1,4-bis[3,4-(methylenedioxy)phenyl]-1H,3H-furo[3,4-c]furan

(+)-5,5'-[(1S,3aβ,4S,6aβ)-Tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl]-bis-1,3-benzodioxole

(+)-5,5'-[(1S,3aβ,4β,6aβ)-Tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl]bis(1,3-benzodioxole)

d-Sesamin

Pseudocubebin

SesaMin(Fagarol)

NSC 36403

SezaMin

(1S,3aR,4S,6aR)-5,5'-(Tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl)bis-1,3-benzodioxole

3-(1,3-benzodioxol-5-yl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-6-ol

(1S,3aR,4S,6aR)-Tetrahydro-1,4-bis[3,4-(Methylenedioxy)phenyl]-1H,3H-Furo[3,4-c]furan

[1S-(1α,3aα,4α,6aα)]-5,5'-(Tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl)bis-1,3-benzodioxole

SESAMIN

FAGAROL

SesaMin, froM SesaMuM indicuM

1,3-Benzodioxole,5,5'-(tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl)bis-, (1S,3aR,4S,6aR)-

Fsesamin

L-Sesamin

Sesamin, >=98%

Sesamin, 98%, from Sesamum indicum

Sesamin&gt

Sesamin USP/EP/BP

Jujube powder

Sesame Extract, Sesamin

5-[(3S,3aR,6S,6aR)-3-(1,3-benzodioxol-5-yl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-6-yl]-1,3-benzodioxole

(1S,3aR,4S,6aR)-1,4-Bis(benzo[d][1,3]dioxol-5-yl)hexahydrofuro[3,4-c]furan

Sesamin (Fagarol, Fsesamin)

Sesamin, ≥95%

TIANFU-CHEM -Sesamin

(+)-sesamin

Sesamin powder

Sesame Extract (Sesamin 90%)

Natural Sesamin Powder

AI3-00811

Sesamin-RM

Abametapir Impurity 28

Sesamin CRS

607-80-7

C20H15O5

C20H18O6

BioChemical

Biochemicals and Reagents

D to K

Enzyme Inhibitors by Enzyme

Enzyme Inhibitors

Enzymes, Inhibitors, and Substrates

D5-Desaturase

Aromatics

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals