Nonivamide
Description References- Product Name
- Nonivamide
- CAS No.
- 2444-46-4
- Chemical Name
- Nonivamide
- Synonyms
- SYNTHETIC CAPSAICIN;N-VANILLYLNONANAMIDE;NON-4-ENE;capscaisin;Capsaicinoid;nonivamide powder;NONYLIC VANILLYLAMIDE;Nonylic acid vanillylamide;PELARGONIC ACID VANILLYLAMIDE;PAVA
- CBNumber
- CB8103743
- Molecular Formula
- C17H27NO3
- Formula Weight
- 293.4
- MOL File
- 2444-46-4.mol
Nonivamide Property
- Melting point:
- 54°C
- Boiling point:
- 200-210 °C(Press: 0.05 Torr)
- Density
- 1,1 g/cm3
- FEMA
- 2787 | NONANOYL 4-HYDROXY-3-METHOXYBENZYLAMIDE
- Flash point:
- 190°C
- storage temp.
- Sealed in dry,2-8°C
- solubility
- methanol: 100 mg/mL, clear to slightly hazy
- form
- powder
- pka
- 9.76±0.20(Predicted)
- color
- white to off-white
- Odor
- bland odorless
- Odor Type
- bland
- JECFA Number
- 1599
- BRN
- 2144300
- Stability:
- Stable. Incompatible with strong oxidizing agents.
- InChIKey
- RGOVYLWUIBMPGK-UHFFFAOYSA-N
- LogP
- 3.43
- CAS DataBase Reference
- 2444-46-4(CAS DataBase Reference)
- EPA Substance Registry System
- Nonanamide, N-[(4-hydroxy-3-methoxyphenyl)methyl]- (2444-46-4)
Safety
- Hazard Codes
- T,Xi
- Risk Statements
- 25-36/37/38-43
- Safety Statements
- 26-45-37/39-36/37
- RIDADR
- UN 3462 6.1/PG 2
- WGK Germany
- 3
- RTECS
- RA5998000
- F
- 19
- HazardClass
- 6.1
- PackingGroup
- II
- HS Code
- 29242990
- Toxicity
- mouse,LD50,intraperitoneal,8mg/kg (8mg/kg),Journal of Medicinal Chemistry. Vol. 36, Pg. 2595, 1993.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H317May cause an allergic skin reaction
H318Causes serious eye damage
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- V9130
- Product name
- N-Vanillylnonanamide
- Purity
- ≥97%, powder
- Packaging
- 1g
- Price
- $68.2
- Updated
- 2024/03/01
- Product number
- S567868
- Product name
- N-VANILLYLNONANOAMIDE
- Purity
- AldrichCPR
- Packaging
- 50mg
- Price
- $179
- Updated
- 2024/03/01
- Product number
- PHL89820
- Product name
- N-Vanillylnonanamide
- Purity
- phyproof? Reference Substance
- Packaging
- 25MG
- Price
- $286
- Updated
- 2024/03/01
- Product number
- 15971
- Product name
- N-Vanillylnonanamide
- Purity
- analytical standard
- Packaging
- 50MG
- Price
- $95.8
- Updated
- 2024/03/01
- Product number
- M0900
- Product name
- N-Vanillylnonanamide [=Capsaicin (Synthetic)]
- Purity
- >98.0%(HPLC)(N)
- Packaging
- 10g
- Price
- $161
- Updated
- 2024/03/01
Nonivamide Chemical Properties,Usage,Production
Description
Nonivamide is also called pelargonic acid vanillylamide or PAVA. It is a capsaicinoid. Nonivamide, isolated from peppers, is a naturally occurring analog of capsaicin (sc-3577). Similar to capsaicin, nonivamide can activate the TRPV1 receptor, thus, stimulate the firing rate of dopaminergic neurons in the ventral tegmental area of the brain and to increase the expression of the serotonin receptor gene HTR2A. Nonivamide is with lower TRPV1 binding affinity, thus, a reduced pungency (9 200 000 scoville heat units) compared to capsaicin (16 000 000 scoville heat units).
Nonivamide is used in the food production to add a hot sensation to flavoring agents and spice mixtures. It is also used in the sweets and confectionary industries to add hot sensation into products. In pharmaceutical industries, nonivamide is used as a cheaper alternative for capsaicin. Warming or heating ointment of nonivamide is used for temporary relief of pain from conditions such as rheumatism, arthritis, lumbao, muscular aches, sprains and strains, sporting injuries and other conditions where local warmth is beneficial. Finalgon is one of the common product utilizing nonivamide for this purpose. Nonivamide is also used as an incapacitant spray, affecting the assailed person’s eyes, causing intense pain and swelling.
References
[1] https://www.scbt.com/scbt/product/nonivamide-2444-46-4
[2] https://pubchem.ncbi.nlm.nih.gov/compound/N-Vanillylnonanamide#section=Clinical-Trials
[3] https://cot.food.gov.uk/sites/default/files/cot/cotsection.pdf
Description
Nonanoyl-4-hydroxy-3-methoxybenzylamide is odorless with a pungent, burning taste. Synthesized from nonanyl chloride and vanillylamine.
Chemical Properties
n-Nonanyl-4-hydroxy-3-methoxybenzyl-amide is an odorless compound, but has a pungent, burning taste
Chemical Properties
solid
Uses
analgesic (topical), depletes Substance P
Uses
N-Vanillylnonanamide is a synthetic analogue of Capsaicin (175680) with similar bioactivity.
Definition
ChEBI: A capsaicinoid that is the carboxamide resulting from the formal condensation of the amino group of 4-hydroxy-3-methoxybenzylamine with the carboxy group of nonanoic acid. It is the active ingredient in many pepper sprays.
Preparation
From nonanyl chloride and vanillylamine.
References
1. m. j. caterina, m. a. schumacher, m. tominaga, t. a. rosen, j. d. levine and d. julius, nature 1997, 389, 816-824. 2. y. g. gil and m. k. kang, life sci 2008, 82, 997-1003. 3. y. s. lee, d. h. nam and j. a. kim, cancer lett 2000, 161, 121-130. 4. h. c. chang, s. t. chen, s. y. chien, s. j. kuo, h. t. tsai and d. r. chen, hum exp toxicol 2011, 30, 1657-1665. 5. k. c. brown, t. r. witte, w. e. hardman, h. luo, y. c. chen, a. b. carpenter, j. k. lau and p. dasgupta, plos one 2010, 5, e10243.>
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View Lastest Price from Nonivamide manufacturers
- Product
- Nonivamide 2444-46-4
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- ≥98% HPLC
- Supply Ability
- 1000KG
- Release date
- 2022-09-30
- Product
- Nonivamide 2444-46-4
- Price
- US $0.00/kg
- Min. Order
- 25kg
- Purity
- 98%
- Supply Ability
- Inquiry
- Release date
- 2023-07-14
- Product
- Nonivamide 2444-46-4
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000tons
- Release date
- 2023-06-20