Nonivamide

ChemicalBook > CAS DataBase List > Nonivamide

Description References

Product Name: Nonivamide
CAS No.: 2444-46-4
Chemical Name: Nonivamide
Synonyms: SYNTHETIC CAPSAICIN;N-VANILLYLNONANAMIDE;NON-4-ENE;capscaisin;Capsaicinoid;nonivamide powder;NONYLIC VANILLYLAMIDE;Nonylic acid vanillylamide;PELARGONIC ACID VANILLYLAMIDE;PAVA
CBNumber: CB8103743
Molecular Formula: C17H27NO3
Formula Weight: 293.4
MOL File: 2444-46-4.mol

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Nonivamide Property

Melting point:: 54°C
Boiling point:: 200-210 °C(Press: 0.05 Torr)
Density: 1,1 g/cm³
FEMA: 2787 | NONANOYL 4-HYDROXY-3-METHOXYBENZYLAMIDE
Flash point:: 190°C
storage temp.: Sealed in dry,2-8°C
solubility: methanol: 100 mg/mL, clear to slightly hazy
form: powder
pka: 9.76±0.20(Predicted)
color: white to off-white
Odor: bland odorless
Odor Type: bland
JECFA Number: 1599
BRN: 2144300
Stability:: Stable. Incompatible with strong oxidizing agents.
InChIKey: RGOVYLWUIBMPGK-UHFFFAOYSA-N
LogP: 3.43
CAS DataBase Reference: 2444-46-4(CAS DataBase Reference)
EPA Substance Registry System: Nonanamide, N-[(4-hydroxy-3-methoxyphenyl)methyl]- (2444-46-4)

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Safety

Hazard Codes: T,Xi
Risk Statements: 25-36/37/38-43
Safety Statements: 26-45-37/39-36/37
RIDADR: UN 3462 6.1/PG 2
WGK Germany: 3
RTECS: RA5998000
F: 19
HazardClass: 6.1
PackingGroup: II
HS Code: 29242990
Toxicity: mouse,LD50,intraperitoneal,8mg/kg (8mg/kg),Journal of Medicinal Chemistry. Vol. 36, Pg. 2595, 1993.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H318Causes serious eye damage

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: V9130
Product name: N-Vanillylnonanamide
Purity: ≥97%, powder
Packaging: 1g
Price: $68.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: S567868
Product name: N-VANILLYLNONANOAMIDE
Purity: AldrichCPR
Packaging: 50mg
Price: $179
Updated: 2024/03/01

Sigma-Aldrich

Product number: PHL89820
Product name: N-Vanillylnonanamide
Purity: phyproof? Reference Substance
Packaging: 25MG
Price: $286
Updated: 2024/03/01

Sigma-Aldrich

Product number: 15971
Product name: N-Vanillylnonanamide
Purity: analytical standard
Packaging: 50MG
Price: $95.8
Updated: 2024/03/01

TCI Chemical

Product number: M0900
Product name: N-Vanillylnonanamide [=Capsaicin (Synthetic)]
Purity: >98.0%(HPLC)(N)
Packaging: 10g
Price: $161
Updated: 2024/03/01

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Nonivamide Chemical Properties,Usage,Production

Description

Nonivamide is also called pelargonic acid vanillylamide or PAVA. It is a capsaicinoid. Nonivamide, isolated from peppers, is a naturally occurring analog of capsaicin (sc-3577). Similar to capsaicin, nonivamide can activate the TRPV1 receptor, thus, stimulate the firing rate of dopaminergic neurons in the ventral tegmental area of the brain and to increase the expression of the serotonin receptor gene HTR2A. Nonivamide is with lower TRPV1 binding affinity, thus, a reduced pungency (9 200 000 scoville heat units) compared to capsaicin (16 000 000 scoville heat units).
Nonivamide is used in the food production to add a hot sensation to flavoring agents and spice mixtures. It is also used in the sweets and confectionary industries to add hot sensation into products. In pharmaceutical industries, nonivamide is used as a cheaper alternative for capsaicin. Warming or heating ointment of nonivamide is used for temporary relief of pain from conditions such as rheumatism, arthritis, lumbao, muscular aches, sprains and strains, sporting injuries and other conditions where local warmth is beneficial. Finalgon is one of the common product utilizing nonivamide for this purpose. Nonivamide is also used as an incapacitant spray, affecting the assailed person’s eyes, causing intense pain and swelling.

References

[1] https://www.scbt.com/scbt/product/nonivamide-2444-46-4
[2] https://pubchem.ncbi.nlm.nih.gov/compound/N-Vanillylnonanamide#section=Clinical-Trials
[3] https://cot.food.gov.uk/sites/default/files/cot/cotsection.pdf

Description

Nonanoyl-4-hydroxy-3-methoxybenzylamide is odorless with a pungent, burning taste. Synthesized from nonanyl chloride and vanillylamine.

Chemical Properties

n-Nonanyl-4-hydroxy-3-methoxybenzyl-amide is an odorless compound, but has a pungent, burning taste

Chemical Properties

solid

Uses

analgesic (topical), depletes Substance P

Uses

N-Vanillylnonanamide is a synthetic analogue of Capsaicin (175680) with similar bioactivity.

Definition

ChEBI: A capsaicinoid that is the carboxamide resulting from the formal condensation of the amino group of 4-hydroxy-3-methoxybenzylamine with the carboxy group of nonanoic acid. It is the active ingredient in many pepper sprays.

Preparation

From nonanyl chloride and vanillylamine.

References

1. m. j. caterina, m. a. schumacher, m. tominaga, t. a. rosen, j. d. levine and d. julius, nature 1997, 389, 816-824. 2. y. g. gil and m. k. kang, life sci 2008, 82, 997-1003. 3. y. s. lee, d. h. nam and j. a. kim, cancer lett 2000, 161, 121-130. 4. h. c. chang, s. t. chen, s. y. chien, s. j. kuo, h. t. tsai and d. r. chen, hum exp toxicol 2011, 30, 1657-1665. 5. k. c. brown, t. r. witte, w. e. hardman, h. luo, y. c. chen, a. b. carpenter, j. k. lau and p. dasgupta, plos one 2010, 5, e10243.>

Nonivamide Preparation Products And Raw materials

Raw materials

Preparation Products

CAPSANTHIN

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View Lastest Price from Nonivamide manufacturers

Changsha Staherb Natural Ingredients Co., Ltd.

Product: Nonivamide 2444-46-4
Price: US $0.00/KG
Min. Order: 1KG
Purity: ≥98% HPLC
Supply Ability: 1000KG
Release date: 2022-09-30

PNP Biotech Co. Ltd

Product: Nonivamide 2444-46-4
Price: US $0.00/kg
Min. Order: 25kg
Purity: 98%
Supply Ability: Inquiry
Release date: 2023-07-14

Wuhan Boyuan Import & Export Co., LTD

Product: Nonivamide 2444-46-4
Price: US $3.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000tons
Release date: 2023-06-20

2444-46-4, NonivamideRelated Search:

CHLOROPHOSPHONAZO III Docosanamide Ethyl 2-(Chlorosulfonyl)acetate Methoxyacetic acid Oxamide p-Anisaldehyde CAPSAICIN, SYNTHETIC ANALOG p-Anisidine Vanillic acid Folic acid Citric acid 4-Methoxybenzoic acid Azelaic acid Nonanoic acid Anisole (Trifluoromethoxy)benzene POLY(ETHYLENE GLYCOL) METHYL ETHER ACRYLATE Stearic acid

Nonivamide(Synthetic Capsaicin)

N-((Hydroxy-3-methoxyphenyl)methyl)4-nonanamide

N-Nonanoyl vanillylamide

Nonanamide, N-((4-hydroxy-3-methoxyphenyl)meth

SYNTHETIC CAPSAICIN

PELARGONYL VANILLYLAMIDE

PELARGONIC ACID VANILLYLAMIDE

N-PELARGONIC ACID VANILLYLAMIDE

N-PELARGONYLVANILLYLAMIDE

NONANOIC ACID VANILLYLAMIDE

NONANYL VANILLYLAMIDE

NONYLIC VANILLYLAMIDE

NONIVAMIDE

NONYLVANYLAMIDE

N-NONYLVANYLAMIDE

N-VANILLYLNONAMIDE

N-VANILLYLNONANAMIDE

N-VANILLYLPELARGONAMIDE

N-(4-HYDROXY-3-METHOXYBENZYL)NONANAMIDE

N-[(4-HYDROXY-3-METHOXYPHENYL)METHYL]-8-METHYL NONANAMIDE

N-[(4-HYDROXY-3-METHOXYPHENYL)METHYL]-NONANAMIDE

VANILLYLNONANAMIDE

VANILLYL PELARGONIC AMIDE

8-METHYL-N-VANILLYLNONENAMIDE

CAPSAICIN (SYNTHETIC)

CAPSAICIN SYNTHETIC ANALOG

CAPSAICINE SYNTHETIC

CAPSAICIN, DIHYDRO-

Capsaicin (synthesis)(=n-Pelargonylvanillylamide)

Capsaicinsynthesispelargonylvanillylamide)

PSEUDOCAPSAICIN(NONIVAMIDE)(P)

PSEUDOCAPSAICIN(SEEPART#03137)(P)

N-VanillylnonanaMide&nbsp

NonvaMide

8-Nordihydrocapsaicin

N-(4-Hydroxy-3-Methoxybenzyl)nonaMide

NSC 172795

N-Nonylvanylamide N-Pelargonic Acid Vanillylamide N-Pelargonylvanillylamide Capsaicin (Synthetic)

NonivaMide Synthetic

Nonivamide Pelargonic acid vanillylamide

capscaisin

Synthetic N-Vanillylnonamide

N-VANILLYLNONANOAMIDE

Nonivamide (pelargonic acid vanillylamide/PAVA)

Capasaicn

nonivamide powder

casaicin

DIHYDROCAPSAICIN(P)

Dihydrocapsacine

NONANOYLVANILLYLAMIDE

N-NONANOYLVANILLYLAMINE

NONANOYLVANILLAMIDE

VANILLYLN-NONOYLAMIDE

PAVA

VANILLYLNONOYLAMIDE

NONYLVANILLYLAMIDE

NONANOYL-4-HYDROXY-3-METHOXY-BENZYLAMINE

N-(4-hydroxy-3-methoxy-benzyl)pelargonamide