ChemicalBook > CAS DataBase List > 4-(1H-1,2,4-Triazol-1-ylmethyl)aniline

4-(1H-1,2,4-Triazol-1-ylmethyl)aniline

Product Name: 4-(1H-1,2,4-Triazol-1-ylmethyl)aniline
CAS No.: 119192-10-8
Chemical Name: 4-(1H-1,2,4-Triazol-1-ylmethyl)aniline
Synonyms: AIDS339154;AIDS-339154;ZERO/004632;BAS 10150896;ZINC00337935;AKOS B030090;AR-011/40584933;Rizatriptan Impurity 11;4-Triazol-1-ylmethyl)aniline;1-(4-AMINOBENZYL)-1,2,4-TRIAZOL
CBNumber: CB0176365
Molecular Formula: C9H10N4
Formula Weight: 174.2
MOL File: 119192-10-8.mol

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4-(1H-1,2,4-Triazol-1-ylmethyl)aniline Property

Melting point:: 124 °C
Boiling point:: 402.1±47.0 °C(Predicted)
Density: 1.26±0.1 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: Chloroform (Slightly), Methanol (Slightly)
pka: 4.42±0.10(Predicted)
form: Powder
color: White to pale yellow
InChI: InChI=1S/C9H10N4/c10-9-3-1-8(2-4-9)5-13-7-11-6-12-13/h1-4,6-7H,5,10H2
InChIKey: ZGLQVRIVLWGDNA-UHFFFAOYSA-N
SMILES: C1(N)=CC=C(CN2C=NC=N2)C=C1
CAS DataBase Reference: 119192-10-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 20/21/22-36/37/38-41-37/38
Safety Statements: 22-26-36/37/39
HazardClass: 6.1
HazardClass: IRRITANT
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: A2148
Product name: 4-(1,2,4-Triazol-1-ylmethyl)aniline
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $16
Updated: 2025/07/31

TCI Chemical

Product number: A2148
Product name: 4-(1,2,4-Triazol-1-ylmethyl)aniline
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $30
Updated: 2025/07/31

TRC

Product number: T767530
Product name: 4-(1H-1,2,4-Triazol-1-ylmethyl)benzenamine
Packaging: 2g
Price: $195
Updated: 2021/12/16

AK Scientific

Product number: J51728
Product name: 4-(1H-1,2,4-triazol-1-ylmethyl)aniline
Packaging: 1g
Price: $10
Updated: 2021/12/16

Chem-Impex

Product number: 44367
Product name: 4-(1,2,4-Triazol-1-ylmethyl)aniline,≥98%(GC)
Purity: ≥98%(GC)
Packaging: 1G
Price: $13.5
Updated: 2021/12/16

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4-(1H-1,2,4-Triazol-1-ylmethyl)aniline Chemical Properties,Usage,Production

Chemical Properties

Brown Solid

Uses

Rizatriptan intermediate

Uses

4-(1H-1,2,4-Triazol-1-ylmethyl)benzenamine is an intermediate useful in organic synthesis and other chemical processes.

Synthesis

119192-09-5

119192-10-8

General procedure for the synthesis of 4-[1H-1,2,4-triazol-1-ylmethyl]aniline from 1-(4-nitrophenyl)methyl-1,2,4-triazole: 1-(4-nitrophenyl)methyl-1,2,4-triazole (10.0 g, 49 mmol) was dissolved in a mixed solvent of ethanol (50 ml) and ethyl acetate (50 ml), 5N HCl (10 ml) and water (1 g). The hydrogenation reaction was carried out in a Parr hydrogenation unit at 40 psi hydrogen pressure using 10% Pd/C catalyst (1.0 g) until the hydrogen uptake reached 188 psi (about 10 min). Upon completion of the reaction, the catalyst was removed by Hyflo filtration and the solvent was removed by concentration under vacuum. The residue was azeotroped twice with ethanol to afford the target product 1-(4-aminophenyl)methyl-1,2,4-triazole hydrochloride (10.6 g, 100%). The product was confirmed by NMR hydrogen spectrum (360 MHz, D2O): δ 5.53 (2H, s, CH2), 7.37-7.48 (4H, m, Ar-H), 8.12 (1H, s, Ar-H), 8.66 (1H, s, Ar-H).

References

[1] Patent: US5567726, 1996, A
[2] Patent: US5298520, 1994, A
[3] Farmaco, 1989, vol. 44, # 9, p. 831 - 841
[4] European Journal of Medicinal Chemistry, 1989, vol. 24, # 5, p. 537 - 540
[5] Patent: US5567819, 1996, A

4-(1H-1,2,4-Triazol-1-ylmethyl)aniline Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-(1H-1,2,4-Triazol-1-ylmethyl)aniline manufacturers

Anhui Ruihan Technology Co., Ltd

Product: 4-(1H-1,2,4-Triazol-1-ylmethyl)aniline 119192-10-8
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000tons
Release date: 2023-09-08

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4-(1H-1,2,4-Triazol-1-ylmethyl)aniline 119192-10-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4-(1,2,4-Triazol-1-ylmethyl)aniline 119192-10-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

119192-10-8, 4-(1H-1,2,4-Triazol-1-ylmethyl)anilineRelated Search:

N,N-Dimethylaniline ANILINE BLACK 3,3',5,5'-Tetramethylbenzidine dihydrochloride Tolyltriazole N,N-Dimethyl-1,4-phenylenediamine Aniline o-Toluidine N-Methylaniline 4-(1H-1,2,4-Triazol-1-ylmethyl)benzenamine hydrochloride 1-[(4-Hydrazinophenyl)methyl]-1H-1,2,4-triazole hydrochloride 1-(4-Nitrophenyl)methyl-1,2,4-triazole Rizatriptan 1,2,4-Triazole 1,2,3-1H-Triazole 1-(4-HYDRAZINOBENZYL)-1H-1,2,4-TRIAZOLE 2-(1H-1,2,4-TRIAZOL-1-YLMETHYL)ANILINE 3-(1H-1,2,4-TRIAZOL-1-YLMETHYL)ANILINE 4-(1H-1,2,4-Triazol-1-ylmethyl)aniline

1-(4-Aminobenzyl)-1H-1,2,4-triazole

4-(1H-1,2,4-Triazol-1-ylmethyl)aniline 97%

4-(1H-1,2,4-triazol-1-ylmethyl)-benzenamine( For Rizatriptan )

4-[1H-1,2,4-TRIAZOLE-1-YL METHYL]BENZENE AMINE (FOR RIZATRIPTAN)

1-(4-Aminophenyl)methyl-1,2,4-Triazole see also 4-(1H-1,2,4-Triazol-1-yl-Methyl)Benzenamine

1-(4-AMINOBENZYL)-1,2,4-TRIAZOL

Benzenamine, 4-(1H-1,2,4-triazol-1-ylmethyl)

AIDS339154

AIDS-339154

AR-011/40584933

BAS 10150896

ZERO/004632

ZINC00337935

1-(4-AMINOPHENYL)METHYL-1,2,4-TRIAZOLE

4-(1H-1,2,4-TRIAZOL-1-YLMETHYL)PHENYLAMINE

4-(1H-1,2,4-TRIAZOL-1-YLMETHYL)ANILINE

4-(1H-1,2,4-TRIAZOL-1-YL-METHYL)BENZENAMINE

4-[1H-1,2,4-TRIAZOL-1-YL METHYL] BENZENEAMINE

1-(4-Aminobenzyl)-1,2,4-triazole

4-(1H-1,2,4-TRIZOL-YL-METHYL)-ANILINE

4-(1 2 4-TRIAZOL-1-YLMETHYL)ANILINE

4-(1H-1,2,4-TRIZOL-1-YL-METHYL)-BENZENAMINE

AKOS B030090

4-[1,2,4]TRIAZOL-1-YLMETHYLPHENYLAMINE

4-(1,2,4-Triazole-1-Yl)Methylphenylamine

4-Triazol-1-ylmethyl)aniline

4-(1,2,4-Triazol-1-ylmethyl)aniline &gt

4-(1H-1,2,4-Triazol-1-ylmethyl)aniline ISO 9001：2015 REACH

Rizatriptan Impurity 11

-(1,2,4-TRIAZOL-1-YLMETHYL)ANILINE

1-(4-Aminobenzyl)-1,2,4-triazole, >98%

119192-10-8

C9H10N4

Intermediates of Rizatriptan

Amine

Aromatics

Heterocycles

Phenyls & Phenyl-Het

Chemical Amines

Amines

Anilines, Aromatic Amines and Nitro Compounds