Rizatriptan
- Product Name
- Rizatriptan
- CAS No.
- 144034-80-0
- Chemical Name
- Rizatriptan
- Synonyms
- CS-281;RIZATRIPTAN;Rizatriptan-d3;Rizatriptan USP/EP/BP;Rizatriptan###144034-80-0;2-(5-((1H-1,2,4-Triazol-1-yl);Acetochlor Impurity 3 (Butachlor);N,N-Dimethyl-5-(1H-1,2,4-trizol-1-ylmethyl)-1H-indole-3-ethanamine;n,n-dimethyl-5-(1h-1,2,4-triazol-1-ylmethyl)-1h-indole-3-ethanamine;1H-Indole-3-ethanaMine,N,N-diMethyl-5-(1H-1,2,4-triazol-1-ylMethyl)-
- CBNumber
- CB3245026
- Molecular Formula
- C15H19N5
- Formula Weight
- 269.34
- MOL File
- 144034-80-0.mol
Rizatriptan Property
- Melting point:
- 178-180°C
- Boiling point:
- 504.8±60.0 °C(Predicted)
- Density
- 1.21±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 16.98±0.30(Predicted)
- Water Solubility
- 42 mg/mL
- CAS DataBase Reference
- 144034-80-0(CAS DataBase Reference)
- EPA Substance Registry System
- Acetonitrile, 2,2-dibromo-2-chloro- (144034-80-0)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H319Causes serious eye irritation
H336May cause drowsiness or dizziness
H361Suspected of damaging fertility or the unborn child
H372Causes damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P281Use personal protective equipment as required.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313IF exposed or concerned: Get medical advice/attention.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P314Get medical advice/attention if you feel unwell.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 076042
- Product name
- 2-(5-((1H-1,2,4-Triazol-1-yl)methyl)-1H-indol-3-yl)-N,N-dimethylethanamine
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $260
- Updated
- 2021/12/16
- Product number
- 076042
- Product name
- 2-(5-((1H-1,2,4-Triazol-1-yl)methyl)-1H-indol-3-yl)-N,N-dimethylethanamine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $559
- Updated
- 2021/12/16
- Product number
- API0006958
- Product name
- RIZATRIPTAN
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1191.96
- Updated
- 2021/12/16
- Product number
- 2800B
- Product name
- Rizatriptan
- Packaging
- 10g
- Price
- $1490
- Updated
- 2021/12/16
- Product number
- AS008491
- Product name
- Rizatriptan
- Purity
- ≥98%
- Packaging
- 1g
- Price
- $478
- Updated
- 2021/12/16
Rizatriptan Chemical Properties,Usage,Production
Uses
Rizatriptan is reported to be a very effective acute migraine drug. It is reported to display high agonist activity at mainly the serotonin 5-HT1B and 5-HT1D receptor subtypes.
Uses
Ca channel blocker
Definition
ChEBI: Rizatriptan is a member of tryptamines. It has a role as a serotonergic agonist, a vasoconstrictor agent and an anti-inflammatory drug. It is functionally related to a N,N-dimethyltryptamine.
brand name
Maxalt (Merck).
General Description
Rizatriptan, approved in 1998, is a fast-acting triptan becauseof its moderate lipophilicity yet has a very shortelimination half-life similar to sumatriptan (i.e., like sumatriptan,it is mainly metabolized by MAO-A). The only advantagesof this drug when compared with sumatriptan arethat it has a slightly faster onset and that it has an orallydisintegrating tablet formulation which can be taken withoutwater.
Clinical Use
5HT1
receptor agonist:
Acute treatment of migraine
Drug interactions
Potentially hazardous interactions with other drugs
Antidepressants: increased risk of CNS excitation
with citalopram - avoid; risk of CNS toxicity
with MAOIs, moclobemide and linezolid - avoid
for 2 weeks after discontinuation of MAOI and
moclobemide; possibly increased serotonergic
effects with duloxetine and venlafaxine; increased
serotonergic effects with St John’s wort - avoid.
Dapoxetine: possible increased risk of serotonergic
effects - avoid for 2 weeks after stopping 5HT1
agonists.
Ergot alkaloids: increased risk of vasospasm - avoid.
Propranolol: rizatriptan levels increased, reduce dose
of rizatriptan to 5 mg (max 10 mg in 24 hours).
Metabolism
The main route of rizatriptan metabolism is via oxidative
deamination by monoamine oxidase-A (MAO-A)
to the indole acetic acid metabolite, which is not
pharmacologically active. N-monodesmethyl-rizatriptan,
a metabolite with activity similar to that of parent
compound, is formed to a minor degree, but does not
contribute significantly to the pharmacodynamic activity
of rizatriptan.
Less than 1% is excreted in the urine as active
N-monodesmethyl metabolite.
Rizatriptan Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Rizatriptan manufacturers
- Product
- Rizatriptan 144034-80-0
- Price
- US $25.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 20 tons
- Release date
- 2023-03-23
- Product
- Rizatriptan 144034-80-0
- Price
- US $1.00-1.00/Kg/Drum
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 50tons
- Release date
- 2020-04-30
- Product
- Rizatriptan 144034-80-0
- Price
- US $200.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000kg/Month
- Release date
- 2022-11-27