Rizatriptan

ChemicalBook > CAS DataBase List > Rizatriptan

Product Name: Rizatriptan
CAS No.: 144034-80-0
Chemical Name: Rizatriptan
Synonyms: CS-281;RIZATRIPTAN;Rizatriptan-d3;Rizatriptan USP/EP/BP;Rizatriptan###144034-80-0;2-(5-((1H-1,2,4-Triazol-1-yl);Acetochlor Impurity 3 (Butachlor);N,N-Dimethyl-5-(1H-1,2,4-trizol-1-ylmethyl)-1H-indole-3-ethanamine;n,n-dimethyl-5-(1h-1,2,4-triazol-1-ylmethyl)-1h-indole-3-ethanamine;1H-Indole-3-ethanaMine,N,N-diMethyl-5-(1H-1,2,4-triazol-1-ylMethyl)-
CBNumber: CB3245026
Molecular Formula: C15H19N5
Formula Weight: 269.34
MOL File: 144034-80-0.mol

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Rizatriptan Property

Melting point:: 178-180°C
Boiling point:: 504.8±60.0 °C(Predicted)
Density: 1.21±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 16.98±0.30(Predicted)
Water Solubility: 42 mg/mL
CAS DataBase Reference: 144034-80-0(CAS DataBase Reference)
EPA Substance Registry System: Acetonitrile, 2,2-dibromo-2-chloro- (144034-80-0)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H319Causes serious eye irritation

H336May cause drowsiness or dizziness

H361Suspected of damaging fertility or the unborn child

H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P281Use personal protective equipment as required.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P314Get medical advice/attention if you feel unwell.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Matrix Scientific

Product number: 076042
Product name: 2-(5-((1H-1,2,4-Triazol-1-yl)methyl)-1H-indol-3-yl)-N,N-dimethylethanamine
Purity: 95+%
Packaging: 250mg
Price: $260
Updated: 2021/12/16

Matrix Scientific

Product number: 076042
Product name: 2-(5-((1H-1,2,4-Triazol-1-yl)methyl)-1H-indol-3-yl)-N,N-dimethylethanamine
Purity: 95+%
Packaging: 1g
Price: $559
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0006958
Product name: RIZATRIPTAN
Purity: 95.00%
Packaging: 1G
Price: $1191.96
Updated: 2021/12/16

AvaChem

Product number: 2800B
Product name: Rizatriptan
Packaging: 10g
Price: $1490
Updated: 2021/12/16

Arctom

Product number: AS008491
Product name: Rizatriptan
Purity: ≥98%
Packaging: 1g
Price: $478
Updated: 2021/12/16

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Rizatriptan Chemical Properties,Usage,Production

Uses

Rizatriptan is reported to be a very effective acute migraine drug. It is reported to display high agonist activity at mainly the serotonin 5-HT1B and 5-HT1D receptor subtypes.

Uses

Ca channel blocker

Definition

ChEBI: Rizatriptan is a member of tryptamines. It has a role as a serotonergic agonist, a vasoconstrictor agent and an anti-inflammatory drug. It is functionally related to a N,N-dimethyltryptamine.

brand name

Maxalt (Merck).

General Description

Rizatriptan, approved in 1998, is a fast-acting triptan becauseof its moderate lipophilicity yet has a very shortelimination half-life similar to sumatriptan (i.e., like sumatriptan,it is mainly metabolized by MAO-A). The only advantagesof this drug when compared with sumatriptan arethat it has a slightly faster onset and that it has an orallydisintegrating tablet formulation which can be taken withoutwater.

Clinical Use

5HT1 receptor agonist:
Acute treatment of migraine

Drug interactions

Potentially hazardous interactions with other drugs
Antidepressants: increased risk of CNS excitation with citalopram - avoid; risk of CNS toxicity with MAOIs, moclobemide and linezolid - avoid for 2 weeks after discontinuation of MAOI and moclobemide; possibly increased serotonergic effects with duloxetine and venlafaxine; increased serotonergic effects with St John’s wort - avoid.
Dapoxetine: possible increased risk of serotonergic effects - avoid for 2 weeks after stopping 5HT1 agonists.
Ergot alkaloids: increased risk of vasospasm - avoid.
Propranolol: rizatriptan levels increased, reduce dose of rizatriptan to 5 mg (max 10 mg in 24 hours).

Metabolism

The main route of rizatriptan metabolism is via oxidative deamination by monoamine oxidase-A (MAO-A) to the indole acetic acid metabolite, which is not pharmacologically active. N-monodesmethyl-rizatriptan, a metabolite with activity similar to that of parent compound, is formed to a minor degree, but does not contribute significantly to the pharmacodynamic activity of rizatriptan.
Less than 1% is excreted in the urine as active N-monodesmethyl metabolite.

Rizatriptan Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Rizatriptan manufacturers

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Rizatriptan 144034-80-0
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 0.98
Supply Ability: 10g
Release date: 2024-05-10

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Rizatriptan 144034-80-0
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 0.98
Supply Ability: 10g
Release date: 2024-05-13

Shaanxi Dideu Medichem Co. Ltd

Product: Rizatriptan 144034-80-0
Price: US $1.00-1.00/Kg/Drum
Min. Order: 1g
Purity: 99%
Supply Ability: 50tons
Release date: 2020-04-30

144034-80-0, RizatriptanRelated Search:

Zolmitriptan Dacthal Dimethyl fumarate Dimethyl sulfate Dimethyl sulfoxide Almotriptan Dimethyl disulfide 1H-Benzotriazole Indole Dimethyl ether 5-Methyl-1H-benzotriazole Sumatriptan ETHANE Dimethyl phthalate Dimethyl carbonate N,N-Dimethylformamide 1,2,4-Triazole Voriconazole

n,n-dimethyl-5-(1h-1,2,4-triazol-1-ylmethyl)-1h-indole-3-ethanamine

n,n-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1h-indol-3-yl]ethanamine

RIZATRIPTAN

diMethyl({2-[5-(1H-1,2,4-triazol-1-ylMethyl)-1H-indol-3-yl]ethyl})aMine

2-(5-((1H-1,2,4-Triazol-1-yl)Methyl)-1H-indol-3-yl)-N,N-diMethylethanaMine

1H-Indole-3-ethanaMine,N,N-diMethyl-5-(1H-1,2,4-triazol-1-ylMethyl)-

Rizatriptan###144034-80-0

2-(5-((1H-1,2,4-Triazol-1-yl)

CS-281

Rizatriptan USP/EP/BP

N,N-Dimethyl-5-(1H-1,2,4-trizol-1-ylmethyl)-1H-indole-3-ethanamine

Rizatriptan-d3

RizatriptanQ: What is Rizatriptan Q: What is the CAS Number of Rizatriptan Q: What is the storage condition of Rizatriptan Q: What are the applications of Rizatriptan

3-[2-(Dimethylamino) ethyl]- 5- (1,2,4- triazol-1- ylmethyl) -indole

Acetochlor Impurity 3 (Butachlor)

144034-80-0

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