Brief description Extraction and Separation Determination of content
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Helicid

Brief description Extraction and Separation Determination of content
Product Name
Helicid
CAS No.
80154-34-3
Chemical Name
Helicid
Synonyms
HELICID;Hiliedum;HELICIDE;HELICIDUM;HILICIDUM;Gynostemma;2-formylphenyl;Tofu glycoside;Helicid/Helicide;Helicid USP/EP/BP
CBNumber
CB0178132
Molecular Formula
C13H16O7
Formula Weight
284.26
MOL File
80154-34-3.mol
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Helicid Property

Melting point:
199-200°C
alpha 
-27 º (c=3.2, MeOH)
Boiling point:
559.9±50.0 °C(Predicted)
Density 
1.510±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
DMF: 1 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
form 
Powder
pka
12.72±0.70(Predicted)
color 
White to Off-white
Water Solubility 
Soluble in hot water. Slightly soluble in water, ethanol or carbinol. Insoluble in aether or chloroform.
InChIKey
OLZAGZCCJJBKNZ-VLJOUNFMSA-N
CAS DataBase Reference
80154-34-3(CAS DataBase Reference)
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Safety

HS Code 
29389090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHL82556
Product name
Helicid
Purity
phyproof? Reference Substance
Packaging
25mg
Price
$286
Updated
2024/03/01
TCI Chemical
Product number
F0542
Product name
4-Formylphenyl beta-D-Allopyranoside
Purity
>98.0%(HPLC)
Packaging
5g
Price
$126
Updated
2024/03/01
Alfa Aesar
Product number
J66102
Product name
4-Formylphenyl beta-D-allopyranoside, 98%
Packaging
5g
Price
$56.65
Updated
2024/03/01
Alfa Aesar
Product number
J66102
Product name
4-Formylphenyl beta-D-allopyranoside, 98%
Packaging
1g
Price
$25.9
Updated
2021/12/16
Usbiological
Product number
300409
Product name
Helicide
Packaging
20mg
Price
$320
Updated
2021/12/16
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Helicid Chemical Properties,Usage,Production

Brief description

Helicid is the active ingredient isolated from the fruit of proteaceae plant Helicia nilagirica, with its chemical structure being similar to gastrodin (hydroxymethyl benzene - O-β-D-glucopyranoside). Pharmacological and clinical studies have shown that helicid has similar effects on the central nervous system with gastrodin, but its sedative, euthanasia and analgesic effect is stronger than gastrodin. The efficacy on the treatment of neurosis efficacy is definite without rebound insomnia and drug dependence. Therefore, it has excellent clinical value. Its fruit tablets have been used in clinical.

Extraction and Separation

Figure 1 the process of purification of helicid from the fruit of proteaceae plant Helicia nilagirica

Determination of content

HPLC method
(1) Chromatographic conditions
Column: YWCT-C18 (25cm × 2.6mm, 10μm) high pressure grouting method. Flowing phase: methanol-water (20:80); flow rate: 0.7 ml / min; column temperature: room temperature; UV detection wavelength: 270 nm; paper speed: 2.5 mm / min.
(2) Reference solution preparation
Precisely weigh control reference substance of helicid; prepare 1 mg/mL solution using 20% methanol. Precise weigh Bergenin; dissolve in 20% methanol; apply ultrasonic solubilization, dub bergenin into about 2mg / ml internal standard solution.
(3) Preparation of sample solution
Accurately weighed dried helicid powder of about 1g, and put it into 25ml volumetric flask; add 20 mL methanol for soak of 0.5 h; ultrasonic extraction 80min, cool, set volume into 25 mL with methanol; filter and filtrate will become the sample solution.
(4) Determination
Take helicid reference solution in 5ml volumetric flask, add bergenin internal standard solution of 1.5ml; diluted with 20% methanol to the mark, mix; take 5 mL sample solution, volatilize; add 1. 5mL the internal standard solution; dilute with 20% methanol to the mark, mix well. Take 5μl of both reference substance and sample solution, inject, determine according to the chromatographic conditions; calculate the content with peak area ratio.
(5) Measurement results
Use the above internal standard method to measure the content of helicid in Samples I and II, and the results were 0.963% and 0.928%.
Its chemical structure is similar to Gastrodia; have a strong analgesic, sedation and euthanasia effect. It is used for the treatment of neurasthenia, neurasthenic syndrome, functional disorders, vascular headache and trigeminal neuralgia. It has remarkable effect on neurasthenic headache, dizziness and sleep disorders.

Chemical Properties

It appears as white needle-like crystals, mp.190 °C ~ 193 °C, [α] D20-100 ° ~ -108 ° (water).

Uses

It is used in the treatment of ischemic cardiovascular and cerebrovascular diseases. Also used in Chinese medicine in the treatment of headache and insomnia.

Definition

ChEBI: Helicid is a glycoside.

Helicid Preparation Products And Raw materials

Raw materials

Preparation Products

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Helicid Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11707
Advantage
57
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7811
Advantage
57
Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85526065 13308475853
Email
ivy@hnhbsj.com
Country
China
ProdList
4552
Advantage
62
Shenzhen Sungening Bio-Tech Co., Ltd
Tel
+86-0755-89668383
Fax
+86-0755-89594066/4038
Email
sales@sungening.com
Country
China
ProdList
1319
Advantage
65
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
meilunui@163.com
Country
China
ProdList
4727
Advantage
58
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View Lastest Price from Helicid manufacturers

Changsha Staherb Natural Ingredients Co., Ltd.
Product
Helicid; Helicia nilagirica extract 80154-34-3
Price
US $0.00/KG
Min. Order
1KG
Purity
≥98% HPLC
Supply Ability
1000KG
Release date
2022-09-16
Xiamen Wonderful Bio Technology Co., Ltd.
Product
Helicid 80154-34-3
Price
US $88.00/kg
Min. Order
1kg
Purity
99.98%
Supply Ability
8000
Release date
2023-07-21
Nanjing Sky Hope Tongyuan Biological Engineering Co., Ltd.
Product
gynostemma
Price
US $75.00/KG
Min. Order
1KG
Purity
80%95%
Supply Ability
100kg
Release date
2021-07-27

80154-34-3, HelicidRelated Search:


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