α-Naphthoflavone
- Product Name
- α-Naphthoflavone
- CAS No.
- 604-59-1
- Chemical Name
- α-Naphthoflavone
- Synonyms
- BENZOFLAVONE;benzo(h)flavone;-Naphthoflavone;α-naphtoflavone;7,8-BENZOFLAVONE;à-naphthoflavone;A-NAPHTHOFLAVONE;1-Naphthoflavone;α-Naphthoflavone;a-Naphthylflavone
- CBNumber
- CB0184955
- Molecular Formula
- C19H12O2
- Formula Weight
- 272.3
- MOL File
- 604-59-1.mol
α-Naphthoflavone Property
- Melting point:
- 153-157 °C (lit.)
- Boiling point:
- 375.35°C (rough estimate)
- Density
- 1.1382 (rough estimate)
- refractive index
- 1.5510 (estimate)
- storage temp.
- 2-8°C
- solubility
- Chloroform (Slightly), Ethyl Acetate (Slightly)
- form
- Crystalline Powder or Crystals
- color
- yellow
- BRN
- 210862
- Stability:
- Stable. Incompatible with strong oxidizing agents.
- LogP
- 5.003 (est)
- CAS DataBase Reference
- 604-59-1(CAS DataBase Reference)
- EPA Substance Registry System
- 4H-Naphtho[1,2-b]pyran-4-one, 2-phenyl- (604-59-1)
Safety
- Hazard Codes
- Xi,Xn,C,F
- Risk Statements
- 68-34-11
- Safety Statements
- 24/25-36/37-45-36/37/39-26-16
- WGK Germany
- 3
- RTECS
- QL6250000
- F
- 8
- Hazard Note
- Irritant
- TSCA
- Yes
- HS Code
- 29143990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H413May cause long lasting harmful effects to aquatic life
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P273Avoid release to the environment.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
N-Bromosuccinimide Price
- Product number
- N5757
- Product name
- α-Naphthoflavone
- Purity
- ≥98%
- Packaging
- 1g
- Price
- $48.9
- Updated
- 2024/03/01
- Product number
- N5757
- Product name
- α-Naphthoflavone
- Purity
- ≥98%
- Packaging
- 5g
- Price
- $51.66
- Updated
- 2024/03/01
- Product number
- B0056
- Product name
- alpha-Naphthoflavone
- Purity
- >98.0%(HPLC)
- Packaging
- 1g
- Price
- $18
- Updated
- 2024/03/01
- Product number
- B0056
- Product name
- alpha-Naphthoflavone
- Purity
- >98.0%(HPLC)
- Packaging
- 5g
- Price
- $50
- Updated
- 2024/03/01
- Product number
- A18542
- Product name
- alpha-Naphthoflavone, 97%
- Packaging
- 5g
- Price
- $51.65
- Updated
- 2024/03/01
α-Naphthoflavone Chemical Properties,Usage,Production
Chemical Properties
yellow powder
Uses
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that promotes the expression of phase I and II xenobiotic chemical metabolizing enzyme genes, including the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2. α-Naphthoflavone is a flavone that modulates xenobiotic metabolism at several points. It antagonizes AhR, blocking the expression of phase I and II genes at nanomolar concentrations, although it can agonize AhR at higher concentrations (10 μM). α-Naphthoflavone inhibits CYP19 (aromatase), CYP1A1, CYP1A2, and CYP1B1 (IC50s = 500, 60, 6, and 5 nM, respectively), whereas it activates CYP3A4 (Kd = 7.4 μM). Dietary α-naphthoflavone can contribute to carcinogenesis in the presence of synthetic estrogens.[Cayman Chemical]
Uses
α-Naphthylflavone is a flavenoid compound that acts on μ-opioid receptors in the treatment of pain. Also acts as a non-steroidal aromatase inhibitor used in breast cancer therapy.
Definition
ChEBI: An extended flavonoid resulting from the formal fusion of a benzene ring with the h side of flavone. A synthetic compound, it is an inhibitor of aromatase (EC 1.14.14.14).
Purification Methods
Recrystallise the flavone from EtOH or aqueous EtOH. [IR: Cramer & Windel Chem Ber 89 354 1956, UV Pillon & Massicot Bull Soc Chim Fr 26 1954, Smith J Chem Soc 542
α-Naphthoflavone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from α-Naphthoflavone manufacturers
- Product
- α-Naphthoflavone 604-59-1
- Price
- US $25.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000 tons
- Release date
- 2023-01-16
- Product
- α-Naphthoflavone 604-59-1
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 20 tons
- Release date
- 2023-11-14
- Product
- α-Naphthoflavone 604-59-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98.0%
- Supply Ability
- 1kg/month
- Release date
- 2023-02-13