ChemicalBook > CAS DataBase List > α-Naphthoflavone

α-Naphthoflavone

Product Name
α-Naphthoflavone
CAS No.
604-59-1
Chemical Name
α-Naphthoflavone
Synonyms
BENZOFLAVONE;benzo(h)flavone;-Naphthoflavone;α-naphtoflavone;7,8-BENZOFLAVONE;à-naphthoflavone;A-NAPHTHOFLAVONE;1-Naphthoflavone;α-Naphthoflavone;a-Naphthylflavone
CBNumber
CB0184955
Molecular Formula
C19H12O2
Formula Weight
272.3
MOL File
604-59-1.mol
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α-Naphthoflavone Property

Melting point:
153-157 °C (lit.)
Boiling point:
375.35°C (rough estimate)
Density 
1.1382 (rough estimate)
refractive index 
1.5510 (estimate)
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), Ethyl Acetate (Slightly)
form 
Crystalline Powder or Crystals
color 
yellow
BRN 
210862
Stability:
Stable. Incompatible with strong oxidizing agents.
LogP
5.003 (est)
CAS DataBase Reference
604-59-1(CAS DataBase Reference)
EPA Substance Registry System
4H-Naphtho[1,2-b]pyran-4-one, 2-phenyl- (604-59-1)
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Safety

Hazard Codes 
Xi,Xn,C,F
Risk Statements 
68-34-11
Safety Statements 
24/25-36/37-45-36/37/39-26-16
WGK Germany 
3
RTECS 
QL6250000
F 
8
Hazard Note 
Irritant
TSCA 
Yes
HS Code 
29143990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
N5757
Product name
α-Naphthoflavone
Purity
≥98%
Packaging
1g
Price
$48.9
Updated
2024/03/01
Sigma-Aldrich
Product number
N5757
Product name
α-Naphthoflavone
Purity
≥98%
Packaging
5g
Price
$51.66
Updated
2024/03/01
TCI Chemical
Product number
B0056
Product name
alpha-Naphthoflavone
Purity
>98.0%(HPLC)
Packaging
1g
Price
$18
Updated
2024/03/01
TCI Chemical
Product number
B0056
Product name
alpha-Naphthoflavone
Purity
>98.0%(HPLC)
Packaging
5g
Price
$50
Updated
2024/03/01
Alfa Aesar
Product number
A18542
Product name
alpha-Naphthoflavone, 97%
Packaging
5g
Price
$51.65
Updated
2024/03/01
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α-Naphthoflavone Chemical Properties,Usage,Production

Chemical Properties

yellow powder

Uses

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that promotes the expression of phase I and II xenobiotic chemical metabolizing enzyme genes, including the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2. α-Naphthoflavone is a flavone that modulates xenobiotic metabolism at several points. It antagonizes AhR, blocking the expression of phase I and II genes at nanomolar concentrations, although it can agonize AhR at higher concentrations (10 μM). α-Naphthoflavone inhibits CYP19 (aromatase), CYP1A1, CYP1A2, and CYP1B1 (IC50s = 500, 60, 6, and 5 nM, respectively), whereas it activates CYP3A4 (Kd = 7.4 μM). Dietary α-naphthoflavone can contribute to carcinogenesis in the presence of synthetic estrogens.[Cayman Chemical]

Uses

α-Naphthylflavone is a flavenoid compound that acts on μ-opioid receptors in the treatment of pain. Also acts as a non-steroidal aromatase inhibitor used in breast cancer therapy.

Definition

ChEBI: An extended flavonoid resulting from the formal fusion of a benzene ring with the h side of flavone. A synthetic compound, it is an inhibitor of aromatase (EC 1.14.14.14).

Purification Methods

Recrystallise the flavone from EtOH or aqueous EtOH. [IR: Cramer & Windel Chem Ber 89 354 1956, UV Pillon & Massicot Bull Soc Chim Fr 26 1954, Smith J Chem Soc 542

α-Naphthoflavone Preparation Products And Raw materials

Raw materials

FLAVANONE FLAVONE trans-Chalcone

Preparation Products

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α-Naphthoflavone Suppliers

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View Lastest Price from α-Naphthoflavone manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
α-Naphthoflavone 604-59-1
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98.0%
Supply Ability
1kg/month
Release date
2023-02-13
Hebei Yanxi Chemical Co., Ltd.
Product
α-Naphthoflavone 604-59-1
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20 tons
Release date
2023-11-14
Hebei Weibang Biotechnology Co., Ltd
Product
α-Naphthoflavone 604-59-1
Price
US $30.00-10.00/KG
Min. Order
50KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-25

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