5-[4-methoxy-3-[(2S)-norbornan-2-yl]oxy-phenyl]-1,3-diazinan-2-one

Product Name: 5-[4-methoxy-3-[(2S)-norbornan-2-yl]oxy-phenyl]-1,3-diazinan-2-one
CAS No.: 135637-46-6
Chemical Name: 5-[4-methoxy-3-[(2S)-norbornan-2-yl]oxy-phenyl]-1,3-diazinan-2-one
Synonyms: AtizoraM;CP 80633;Atizoram, CP-80633;5-[4-methoxy-3-[(2S)-norbornan-2-yl]oxy-phenyl]-1,3-diazinan-2-one;5-[3-[(1S,2S,4R)-Bicyclo[2.2.1]hept-2-yloxy]-4-methoxyphenyl]tetrahydro-2(1H)-pyrimidinone;2(1H)-Pyrimidinone, 5-[3-[(1S,2S,4R)-bicyclo[2.2.1]hept-2-yloxy]-4-methoxyphenyl]tetrahydro-
CBNumber: CB01855618
Molecular Formula: C18H24N2O3
Formula Weight: 316.39
MOL File: 135637-46-6.mol

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5-[4-methoxy-3-[(2S)-norbornan-2-yl]oxy-phenyl]-1,3-diazinan-2-one Property

Boiling point:: 543.0±50.0 °C(Predicted)
Density: 1.178±0.06 g/cm3(Predicted)
storage temp.: Store at +4°C
solubility: DMF: 3 mg/ml; DMF:PBS (pH 7) (1:10): 0.1 mg/ml; DMSO: 2 mg/ml
form: A crystalline solid
pka: 14.05±0.40(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 13183
Product name: CP 80,633
Purity: ≥95%
Packaging: 500μg
Price: $28
Updated: 2024/03/01

Cayman Chemical

Product number: 13183
Product name: CP 80,633
Purity: ≥95%
Packaging: 1mg
Price: $50
Updated: 2024/03/01

Cayman Chemical

Product number: 13183
Product name: CP 80,633
Purity: ≥95%
Packaging: 5mg
Price: $207
Updated: 2024/03/01

Cayman Chemical

Product number: 13183
Product name: CP 80,633
Purity: ≥95%
Packaging: 10mg
Price: $357
Updated: 2024/03/01

Tocris

Product number: 2729
Product name: CP80633
Purity: ≥99%(HPLC)
Packaging: 50
Price: $834
Updated: 2021/12/16

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5-[4-methoxy-3-[(2S)-norbornan-2-yl]oxy-phenyl]-1,3-diazinan-2-one Chemical Properties,Usage,Production

Uses

Phosphodiesterases (PDE) enzymatically convert the cyclic nucleotide second messengers cAMP and cGMP to 5’-AMP and 5’-GMP, respectively, thus terminating signal transduction. The cAMP-specific PDE4 isoforms may be particularly important in certain respiratory and neurological diseases. CP 80,633 is a selective inhibitor of PDE4 (IC50 = 1.27 μM for PDE4 versus. >100 μM for PDE1, PDE2, PDE3, and PDE5). It potentiates PGE1-dependent increases in cAMP levels in eosinophils, monocytes, and T-cells, inhibits eosinophil superoxide production (IC50 < 0.6 μM), and blocks LPS-induced TNF-α release from monocytes (IC50 = 0.22 μM). CP 80,633 (1 mg/kg) significantly reduces antigen-induced airway inflammation in atopic guinea pigs, monkeys, and mice.[Cayman Chemical]

Uses

CP 80633 is a selective inhibitor of phosphodiesterase type 4.

Definition

ChEBI: 2(1h)-pyrimidinone, 5-[3-[(1s,2s,4r)-bicyclo[2.2.1]hept-2-yloxy]-4-methoxyphenyl]tetrahydro- is a monoterpenoid.

Biological Activity

Selective inhibitor of phosphodiesterase type 4 (IC 50 values are 1.9, > 100, > 100, > 100 and > 100 μ M for human lung PDE4, lung PDE1, lung PDE2, heart PDE3 and platelet PDE-V respectively) that displays no significant PDE4 isozyme selectivity. Inhibits hydrolysis of cAMP in isolated human peripheral blood monocytes, eosinophils and T cells.? Displays anti-inflammatory and bronchodilatory effects in vivo .

5-[4-methoxy-3-[(2S)-norbornan-2-yl]oxy-phenyl]-1,3-diazinan-2-one Preparation Products And Raw materials

Raw materials

Preparation Products

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5-[4-methoxy-3-[(2S)-norbornan-2-yl]oxy-phenyl]-1,3-diazinan-2-one Suppliers

China 30 United Kingdom 1 United States 5 USA 1 Global 37

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135637-46-6, 5-[4-methoxy-3-[(2S)-norbornan-2-yl]oxy-phenyl]-1,3-diazinan-2-oneRelated Search:

5-[4-methoxy-3-[(2S)-norbornan-2-yl]oxy-phenyl]-1,3-diazinan-2-one

5-[3-[(1S,2S,4R)-Bicyclo[2.2.1]hept-2-yloxy]-4-methoxyphenyl]tetrahydro-2(1H)-pyrimidinone

CP 80633

AtizoraM

Atizoram, CP-80633

2(1H)-Pyrimidinone, 5-[3-[(1S,2S,4R)-bicyclo[2.2.1]hept-2-yloxy]-4-methoxyphenyl]tetrahydro-

135637-46-6