5-[4-methoxy-3-[(2S)-norbornan-2-yl]oxy-phenyl]-1,3-diazinan-2-one
- Product Name
- 5-[4-methoxy-3-[(2S)-norbornan-2-yl]oxy-phenyl]-1,3-diazinan-2-one
- CAS No.
- 135637-46-6
- Chemical Name
- 5-[4-methoxy-3-[(2S)-norbornan-2-yl]oxy-phenyl]-1,3-diazinan-2-one
- Synonyms
- AtizoraM;CP 80633;Atizoram, CP-80633;5-[4-methoxy-3-[(2S)-norbornan-2-yl]oxy-phenyl]-1,3-diazinan-2-one;5-[3-[(1S,2S,4R)-Bicyclo[2.2.1]hept-2-yloxy]-4-methoxyphenyl]tetrahydro-2(1H)-pyrimidinone;2(1H)-Pyrimidinone, 5-[3-[(1S,2S,4R)-bicyclo[2.2.1]hept-2-yloxy]-4-methoxyphenyl]tetrahydro-
- CBNumber
- CB01855618
- Molecular Formula
- C18H24N2O3
- Formula Weight
- 316.39
- MOL File
- 135637-46-6.mol
5-[4-methoxy-3-[(2S)-norbornan-2-yl]oxy-phenyl]-1,3-diazinan-2-one Property
- Boiling point:
- 543.0±50.0 °C(Predicted)
- Density
- 1.178±0.06 g/cm3(Predicted)
- storage temp.
- Store at +4°C
- solubility
- DMF: 3 mg/ml; DMF:PBS (pH 7) (1:10): 0.1 mg/ml; DMSO: 2 mg/ml
- form
- A crystalline solid
- pka
- 14.05±0.40(Predicted)
N-Bromosuccinimide Price
- Product number
- 13183
- Product name
- CP 80,633
- Purity
- ≥95%
- Packaging
- 500μg
- Price
- $28
- Updated
- 2024/03/01
- Product number
- 13183
- Product name
- CP 80,633
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $50
- Updated
- 2024/03/01
- Product number
- 13183
- Product name
- CP 80,633
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $207
- Updated
- 2024/03/01
- Product number
- 13183
- Product name
- CP 80,633
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $357
- Updated
- 2024/03/01
- Product number
- 2729
- Product name
- CP80633
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $834
- Updated
- 2021/12/16
5-[4-methoxy-3-[(2S)-norbornan-2-yl]oxy-phenyl]-1,3-diazinan-2-one Chemical Properties,Usage,Production
Uses
Phosphodiesterases (PDE) enzymatically convert the cyclic nucleotide second messengers cAMP and cGMP to 5’-AMP and 5’-GMP, respectively, thus terminating signal transduction. The cAMP-specific PDE4 isoforms may be particularly important in certain respiratory and neurological diseases. CP 80,633 is a selective inhibitor of PDE4 (IC50 = 1.27 μM for PDE4 versus. >100 μM for PDE1, PDE2, PDE3, and PDE5). It potentiates PGE1-dependent increases in cAMP levels in eosinophils, monocytes, and T-cells, inhibits eosinophil superoxide production (IC50 < 0.6 μM), and blocks LPS-induced TNF-α release from monocytes (IC50 = 0.22 μM). CP 80,633 (1 mg/kg) significantly reduces antigen-induced airway inflammation in atopic guinea pigs, monkeys, and mice.[Cayman Chemical]
Uses
CP 80633 is a selective inhibitor of phosphodiesterase type 4.
Definition
ChEBI: 2(1h)-pyrimidinone, 5-[3-[(1s,2s,4r)-bicyclo[2.2.1]hept-2-yloxy]-4-methoxyphenyl]tetrahydro- is a monoterpenoid.
Biological Activity
Selective inhibitor of phosphodiesterase type 4 (IC 50 values are 1.9, > 100, > 100, > 100 and > 100 μ M for human lung PDE4, lung PDE1, lung PDE2, heart PDE3 and platelet PDE-V respectively) that displays no significant PDE4 isozyme selectivity. Inhibits hydrolysis of cAMP in isolated human peripheral blood monocytes, eosinophils and T cells.? Displays anti-inflammatory and bronchodilatory effects in vivo .