2-HYDROXY-3-NITROACETOPHENONE
- Product Name
- 2-HYDROXY-3-NITROACETOPHENONE
- CAS No.
- 28177-69-7
- Chemical Name
- 2-HYDROXY-3-NITROACETOPHENONE
- Synonyms
- 2-HYDROXY-3-NITROACETOPHENONE;2’-hydroxy-3-nltroacetophenone;2’-Hydroxy-3’-nitroacetophenone;1-(2-HYDROXY-3-NITRO-PHENYL)-ETHANONE;Ethanone, 1-(2-hydroxy-3-nitrophenyl)-;1-(2-hydroxy-3-nitrophenyl)ethan-1-one;2-hydroxy-1-(3-nitrophenyl)ethan-1-one
- CBNumber
- CB0186207
- Molecular Formula
- C8H7NO4
- Formula Weight
- 181.15
- MOL File
- 28177-69-7.mol
2-HYDROXY-3-NITROACETOPHENONE Property
- Melting point:
- 98.5-99.5 °C
- Boiling point:
- 223.5±20.0 °C(Predicted)
- Density
- 1.380±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 7.31±0.24(Predicted)
- Appearance
- Yellow to brown Solid
- InChI
- InChI=1S/C8H7NO4/c1-5(10)6-3-2-4-7(8(6)11)9(12)13/h2-4,11H,1H3
- InChIKey
- XQZGSPSZLMKODN-UHFFFAOYSA-N
- SMILES
- C(=O)(C1=CC=CC([N+]([O-])=O)=C1O)C
- CAS DataBase Reference
- 28177-69-7(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- H950973
- Product name
- 2-Hydroxy-3-nitroacetophenone
- Packaging
- 500mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- W5104
- Product name
- 1-(2-Hydroxy-3-nitrophenyl)ethanone
- Packaging
- 5g
- Price
- $162
- Updated
- 2021/12/16
- Product number
- CHM0016604
- Product name
- 1-(2-HYDROXY-3-NITRO-PHENYL)-ETHANONE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $921.69
- Updated
- 2021/12/16
- Product number
- CHM0016604
- Product name
- 1-(2-HYDROXY-3-NITRO-PHENYL)-ETHANONE
- Purity
- 95.00%
- Packaging
- 25G
- Price
- $1552.32
- Updated
- 2021/12/16
- Product number
- W5104
- Product name
- 1-(2-Hydroxy-3-nitrophenyl)ethanone
- Packaging
- 10g
- Price
- $235
- Updated
- 2021/12/16
2-HYDROXY-3-NITROACETOPHENONE Chemical Properties,Usage,Production
Preparation
Preparation by reaction of boiling 5% aqueous potassium hydroxide on 8-nitrochromone (78%).
Synthesis
118-93-4
1450-76-6
28177-69-7
General procedure for the synthesis of 2-hydroxy-5-nitroacetophenone and 2-hydroxy-3-nitroacetophenone from 2'-hydroxyacetophenone: In a four-necked flask, 2'-hydroxyacetophenone (175 g), acetic acid (183 g), and dichloromethane (800 mL) were added sequentially, and the mixture was heated to 40 °C. Subsequently, 63% concentrated nitric acid (165 g) was slowly added dropwise, and the reaction temperature was controlled to be maintained at 40 °C for 4-6 hours. After completion of the dropwise addition, the reaction was continued at 40 °C for 4-6 hours. At the end of the reaction, water (500 g) was added and stirred for 30 minutes for extraction and layering. The organic layer was concentrated to about 200 g of crude product. The above crude product (200 g) was added to a four-necked flask with toluene (900 g), heated to 60-70 °C and reacted at 70-80 °C for 2-4 hours. The reaction mixture was cooled to 30-50 °C and filtered and the filter cake was dried. The dried filter cake was transferred to a four-necked flask, methanol (100 g) and water (800 g) were added and heated to 50-60°C. The reaction mixture was cooled to 30-50°C and filtered. Acetic acid (150 g) was added slowly dropwise and controlled to be added dropwise within 2 hours at 60-70 °C. The reaction mixture was cooled to room temperature and filtered, and the filter cake was dried to give the product A-2 (80 g).
References
[1] Journal of Medicinal Chemistry, 1994, vol. 37, # 20, p. 3353 - 3362
[2] Journal of Medicinal Chemistry, 1994, vol. 37, # 20, p. 3353 - 3362
[3] Asian Journal of Chemistry, 2015, vol. 27, # 6, p. 2117 - 2124
[4] Patent: WO2009/85256, 2009, A1. Location in patent: Page/Page column 55
[5] Patent: CN103980257, 2016, B. Location in patent: Paragraph 0033; 0034; 0035
2-HYDROXY-3-NITROACETOPHENONE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-HYDROXY-3-NITROACETOPHENONE manufacturers
- Product
- 2-HYDROXY-3-NITROACETOPHENONE 28177-69-7
- Price
- US $10.00/ASSAYS
- Min. Order
- 1ASSAYS
- Purity
- 99%
- Supply Ability
- 1 ton
- Release date
- 2025-08-28
- Product
- 2-HYDROXY-3-NITROACETOPHENONE 28177-69-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-07
- Product
- 2-HYDROXY-3-NITROACETOPHENONE 28177-69-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11