H-ALA-NHME HCL
- Product Name
- H-ALA-NHME HCL
- CAS No.
- 61275-22-7
- Chemical Name
- H-ALA-NHME HCL
- Synonyms
- H-Ala-NHMe;L-Ala-NHMe·HCl;H-ALA-NHME HCL;ALANINE-NHME HCL;N-methyl-L-alaninamide;H-Ala-NHMe hydrochloride;L-Alanine MethylaMide HCl;L-ALANINE METHYLAMIDE HYDROCHLORIDE;L-ALANINE N-METHYLAMIDE HYDROCHLORIDE;propanamide, 2-amino-N-methyl-, (2S)-
- CBNumber
- CB0188014
- Molecular Formula
- C4H11ClN2O
- Formula Weight
- 138.6
- MOL File
- 61275-22-7.mol
H-ALA-NHME HCL Property
- Melting point:
- 218-220 °C(Solv: methanol (67-56-1); ethyl ether (60-29-7))
- storage temp.
- Inert atmosphere,Room Temperature
- form
- solid
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A614020
- Product name
- H-Ala-NHMehydrochloride
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 451581
- Product name
- H-Ala-NHMe HCl
- Packaging
- 100mg
- Price
- $305
- Updated
- 2021/12/16
- Product number
- 05833
- Product name
- L-Alaninemethylamidehydrochloride,98%(HPLC)
- Purity
- 98%(HPLC)
- Packaging
- 250MG
- Price
- $39.2
- Updated
- 2021/12/16
- Product number
- FA48633
- Product name
- L-Alanine methylamide hydrochloride
- Packaging
- 500mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 05833
- Product name
- L-Alanine methylamide hydrochloride
- Purity
- ≥ 98% (HPLC)
- Packaging
- 1G
- Price
- $65
- Updated
- 2021/12/16
H-ALA-NHME HCL Chemical Properties,Usage,Production
Chemical Properties
White powder or solid
Uses
H-Ala-NHMe HCl
Synthesis
1115-59-9
61275-22-7
The general procedure for the synthesis of (S)-2-amino-N-methylpropionamide hydrochloride from L-alanine ethyl ester hydrochloride was as follows: ethyl L-alanine ethyl ester hydrochloride (8.1 g, 52.4 mmol) was dissolved in ethanol-methylamine solution (36 mL, 289 mmol), and the reaction was stirred for 97 hours. Upon completion of the reaction, the solvent was removed by evaporation. The residue was dissolved in 4 M potassium carbonate solution (30 mL) and saturated sodium bicarbonate solution (20 mL) and subsequently extracted with chloroform (5 × 25 mL). The organic phases were combined, dried over sodium carbonate and evaporated to give the crude (S)-2-amino-N-methylpropionamide as a red oil (3.62 g, 35.5 mmol, 68% yield). The free amine (1.9 g, 18.5 mmol) was dissolved in ether (200 mL) and treated by passing hydrogen chloride gas for 10 min. At the end of the reaction, the product was collected by filtration and washed with ether to afford (S)-2-amino-N-methylpropionamide hydrochloride as clarified crystals (2.2 g, 16.0 mmol, 86% yield). The product was further purified by recrystallization from ethanol and hexane; melting point 213-215 °C; [α]D25 +19.6 (c 0.1, CH3OH); νmax (NaCl disk)/cm-1 3408, 1674, 1514, 1417, 1275, 1169; δH (400 MHz, D2O) 3.85 (1H, q, J 7.1 Hz, CH), 2.60 (3H, s, NCH3), 1.32 (3H, d, J 7.1 Hz, CCH3); δC (100 MHz, D2O) 174.1 (C), 51.2 (CH), 28.5 (CH3), 19.2 (CH3).
References
[1] Tetrahedron, 2011, vol. 67, # 23, p. 4263 - 4267
H-ALA-NHME HCL Preparation Products And Raw materials
Raw materials
Preparation Products
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