L-Alaninamide hydrochloride
- Product Name
- L-Alaninamide hydrochloride
- CAS No.
- 33208-99-0
- Chemical Name
- L-Alaninamide hydrochloride
- Synonyms
- H-ALA-NH2 HCL;L-ALANAMINE HCL;L-ALANINE AMIDE HYDROCHLORIDE;(2S)-2-AMINOPROPANAMIDE HYDROCHLORIDE;Ala-NH2.Hcl;L-Ala-NH2·HCl;H-L-ALA-NH2 HCL;ALANINE-NH2 HCL;L-ALANILAMIDE HCL;：L-Alaninamide hyd
- CBNumber
- CB7766754
- Molecular Formula
- C3H9ClN2O
- Formula Weight
- 124.57
- MOL File
- 33208-99-0.mol
L-Alaninamide hydrochloride Property
- Melting point:
- 212-217°C
- alpha
- 11 º (c=1, MeOH)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly), Water
- form
- Solid
- color
- White to Off-White
- optical activity
- [α]25/D +11.0°, c = 1 in methanol
- InChI
- InChI=1S/C3H8N2O.ClH/c1-2(4)3(5)6;/h2H,4H2,1H3,(H2,5,6);1H/t2-;/m0./s1
- InChIKey
- FIAINKIUSZGVGX-DKWTVANSSA-N
- SMILES
- [C@H](N)(C)C(=O)N.Cl
- CAS DataBase Reference
- 33208-99-0(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- 459216
- Product name
- L-Alaninamide hydrochloride
- Purity
- 95%
- Packaging
- 1g
- Price
- $26.8
- Updated
- 2025/07/31
- Product number
- 459216
- Product name
- L-Alaninamide hydrochloride
- Purity
- 95%
- Packaging
- 5g
- Price
- $60.9
- Updated
- 2025/07/31
- Product number
- A1919
- Product name
- L-Alaninamide Hydrochloride
- Purity
- >97.0%(N)
- Packaging
- 5g
- Price
- $26
- Updated
- 2025/07/31
- Product number
- A1919
- Product name
- L-Alaninamide Hydrochloride
- Purity
- >97.0%(N)
- Packaging
- 25g
- Price
- $75
- Updated
- 2025/07/31
- Product number
- A481450
- Product name
- L-AlanineAmideHydrochloride
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
L-Alaninamide hydrochloride Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powder
Uses
L-Alaninamide hydrochloride is used for preparation of novel amide derivatives of steroidal[3,2-c]pyrazole compounds with glucocorticoid activity.
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
2491-20-5
33208-99-0
The general procedure for the synthesis of L-alaninamide hydrochloride from alanine methyl ester hydrochloride is as follows: 500 g of methanol and 100 g of L-alanine were added to a 1000 ml three-necked flask, followed by the slow dropwise addition of 90 ml of thionyl chloride (the reaction temperature was controlled to be below 35 °C). After the dropwise addition, the three-necked flask was transferred to a water bath, heated to reflux temperature (temperature not exceeding 35 °C) and ensured that the generated SO2 was completely removed.Subsequently, the aminolysis reaction was carried out by passing 0.56 kg of ammonia into the reaction system under ice-bath conditions (temperature controlled below 20 °C), after which the reaction mixture was sealed and allowed to stand for 20 h in a room temperature water bath. The temperature of the water bath was raised to 55 °C to remove the remaining ammonia gas, which was finally concentrated to 300 ml and ensured that the ammonia gas was completely removed. Excess ammonium chloride was removed by filtration and the filter cake was washed with 100 ml of methanol, the washings were combined with the mother liquor and transferred to a 1000 ml beaker. The acidification process was completed by slowly adding 34.5 ml of hydrochloric acid at 10% concentration dropwise and adjusting the pH to 1.55. The reaction mixture was sealed and placed in a refrigerator for 12 h. After removal, 400 ml of acetone was added to induce crystallization. The crystals were collected by filtration, washed with an appropriate amount of solvent and subsequently dried at 45 °C for 12 h. 85 g of white crystals were obtained (85% yield). The rotativity of the product was [a] = +11.4°.
References
[1] Journal fur Praktische Chemie - Chemiker - Zeitung, 1996, vol. 338, # 3, p. 251 - 256
[2] Patent: CN108069867, 2018, A. Location in patent: Paragraph 0015-0017
L-Alaninamide hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from L-Alaninamide hydrochloride manufacturers
- Product
- L-Alaninamide hydrochloride 33208-99-0
- Price
- US $0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 10 tons
- Release date
- 2021-08-09
- Product
- L-Alaninamide hydrochloride 33208-99-0
- Price
- US $999.00-800.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000
- Release date
- 2024-08-22
- Product
- ALA-NH2.HCL 33208-99-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98+
- Supply Ability
- 1T
- Release date
- 2023-11-27