H-ALPHA-ME-D-PRO-OH

Product Name: H-ALPHA-ME-D-PRO-OH
CAS No.: 63399-77-9
Chemical Name: H-ALPHA-ME-D-PRO-OH
Synonyms: EOS-61196;α-Me-D-Pro-OH;H-a-Me-D-Pro-OH;D-5-Methylproline;2-methyl-D-proline;H-ALPHA-ME-D-PRO-OH;(R)-2-Methylproline;(R)-a-Methyl-proline;H-a-Methyl-D-proline;D-Proline, 2-methyl-
CBNumber: CB0191265
Molecular Formula: C6H11NO2
Formula Weight: 129.16
MOL File: 63399-77-9.mol

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H-ALPHA-ME-D-PRO-OH Property

Melting point:: 340℃ (DEC.)
Boiling point:: 241.9±33.0 °C(Predicted)
Density: 1.119
storage temp.: Sealed in dry,Room Temperature
form: powder
pka: 2.44±0.20(Predicted)
color: White
optical activity: 76.369°(C=0.01g/ml MEOH)

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: M265385
Product name: (R)-2-MethylProline
Packaging: 250mg
Price: $195
Updated: 2021/12/16

Chem-Impex

Product number: 14286
Product name: D-α-Methylproline,95%(NMR)
Purity: 95%(NMR)
Packaging: 250MG
Price: $123.2
Updated: 2021/12/16

Apolloscientific

Product number: OR962960
Product name: (2R)-2-Methylpyrrolidine-2-carboxylicacid
Purity: 95%
Packaging: 1g
Price: $131
Updated: 2021/12/16

ChemScene

Product number: CS-M0572
Product name: (R)-2-methylpyrrolidine-2-carboxylicacid
Purity: >97.0%
Packaging: 1g
Price: $62
Updated: 2021/12/16

Chem-Impex

Product number: 14286
Product name: D-α-Methylproline,≥95%(NMR)
Purity: ≥95%(NMR)
Packaging: 100MG
Price: $69.89
Updated: 2021/12/16

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H-ALPHA-ME-D-PRO-OH Chemical Properties,Usage,Production

Uses

(R)-2-Methyl Proline is a derivative of D-Proline (P755990) which is used in the synthesis of (R)-(+)-N-Boc-Pipecolic Acid, (S)-(-)-Coniine, (S)-(+)-Pelletierine, (+)-.beta.-Conhydrine, and (S)-(-)-Ropivacaine and formal synthesis of (-)-Lasubine II and (+)-Cermizine C.

Synthesis

848488-83-5

42856-71-3

63399-77-9

The general procedure for the synthesis of (S)-2-methylproline and (R)-2-methylpyrrolidine-2-carboxylic acid from the compounds (CAS: 848488-83-5) is as follows: (R)-α-methylproline amide (0.40 g, 58% purity, 1.78 mmol) prepared in Reference Example 4 was added to a reaction flask with 6 M hydrochloric acid (2 mL) and stirred at 90°C for The reaction was carried out for 4 hours. Upon completion of the reaction, the product was analyzed by high performance liquid chromatography (HPLC) to confirm the presence of (R)-α-methylproline (204 mg, 1.58 mmol) in 90% yield and 89% ee optical purity.

References

[1] Patent: EP2716629, 2014, A1. Location in patent: Paragraph 0208; 0209
[2] Patent: JP5959417, 2016, B2. Location in patent: Paragraph 0175

H-ALPHA-ME-D-PRO-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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H-ALPHA-ME-D-PRO-OH Suppliers

China 113 Europe 1 Germany 1 India 5 United States 9 Global 129

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
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View Lastest Price from H-ALPHA-ME-D-PRO-OH manufacturers

Hebei Fengjia New Material Co., Ltd

Product: H-ALPHA-ME-D-PRO-OH 63399-77-9
Price: US $3.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 100000
Release date: 2024-08-19

Hebei Chuanghai Biotechnology Co., Ltd

Product: H-ALPHA-ME-D-PRO-OH 63399-77-9
Price: US $9.90/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2025-03-13

Nanjing Fred Technology Co., Ltd

Product: 2-Methyl-D-proline 63399-77-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1 ton
Release date: 2023-12-26

63399-77-9, H-ALPHA-ME-D-PRO-OHRelated Search:

2-Piperidinecarboxylicacid,2-methyl-,(R)-(9CI) (S)-ALPHA-BENZYL-PROLINE-HCL (S)-ALPHA-(2-FLUOROBENZYL)-PROLINE-HCL (R)-ALPHA-(3-PHENYL-PROPYL)-PROLINE-HCL BOC-(R)-ALPHA-(3-PHENYL-PROPYL)-PROLINE (R)-ALPHA-PHENETHYL-L-PROLINE-HCL BOC-(S)-ALPHA-(1-NAPHTHALENYLMETHYL)-PROLINE (S)-ALPHA-(1-NAPHTHALENYLMETHYL)-PROLINE-HCL (S)-ALPHA-(3-FLUOROBENZYL)-PROLINE-HCL BOC-(R)-ALPHA-PHENETHYL-L-PROLINE (S)-ALPHA-(3-PHENYL-ALLYL)-PROLINE-HCL BOC-(S)-ALPHA-BENZYL-PROLINE (S)-ALPHA-(4-BIPHENYLMETHYL)-PROLINE-HCL (S)-ALPHA-(2-NAPHTHALENYLMETHYL)-PROLINE-HCL CLASTO-LACTACYSTIN BETA-LACTONE BOC-(S)-ALPHA-(2-NAPHTHALENYLMETHYL)-PROLINE BOC-(S)-ALPHA-(2-FLUOROBENZYL)-PROLINE methyl 7-azabicyclo[2.2.1]heptane-1-carboxylate hydrochloride

(R)-2-Methylpyrrolidine-2-carboxylic acid

H-alpha-Methyl-D-proline

H-a-Methyl-D-proline

2-Methyl-D-proline hydroc...

(2R)-2-methylpyrrolidine-2-carboxylic acid

(R)-2-Methylproline Hydrochloride, ≥98%

(R)-a-Methyl-proline

2-Methyl-D-proline hydrochloride

α-Me-D-Pro-OH

H-ALPHA-ME-D-PRO-OH

D-ALPHA-METHYLPROLINE

(2r,5r)-5-Methylpyrrolidine-2-Carboxylic Acid

D-5-Methylproline

D-Proline, 2-methyl- (9CI)

alpha-Methyl-D-proline, (R)-a-Methyl-proline

H-a-Me-D-Pro-OH

(R)-2-Methylproline

2-methyl-D-proline

2-methyl-D-proline(SALTDATA: HCl)

EOS-61196

Alpha-Methyl-D-Pro-OH

(R)-2-Methylproline Hydrochloride

ALPHA-METHYL-D-PROLINE

D-Proline, 2-methyl-

(R)-2-Methylpyrrolidine-2-carboxylicaci

H-ALPHA-ME-D-PRO-OH USP/EP/BP

(R)-2-methylpyrolidine-2-carboxylic acid (DeMepro)

63399-77-9

14388-65-5

63366-77-6

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