CLASTO-LACTACYSTIN BETA-LACTONE

Product Name: CLASTO-LACTACYSTIN BETA-LACTONE
CAS No.: 154226-60-5
Chemical Name: CLASTO-LACTACYSTIN BETA-LACTONE
Synonyms: OMURALIDE;BETA-CLASTOLACTACYSTIN;Clasto-Lactacystin β-lactone;clasto-lactacystin β-lactone;Clasto-lactacystin (OMuralide);CLASTO-LACTACYSTIN BETA-LACTONE;LACTACYSTIN, CLASTO-, BETA-LACTONE;1R-[1S-1HYDROXY-2-METHYLPROPYL]-4R-METHYL-6-OXA-2-AZABICYCLO[3.2.0]HEPTANE-3,7-DIONE;(1R,4R,5S)-1-[(1S)-1-Hydroxy-2-Methylpropyl]-4-Methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione;6-Oxa-2-azabicyclo[3.2.0]heptane-3,7-dione, 1-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-, (1R,4R,5S)-
CBNumber: CB9352564
Molecular Formula: C10H15NO4
Formula Weight: 213.23
MOL File: 154226-60-5.mol

More

Less

CLASTO-LACTACYSTIN BETA-LACTONE Property

Melting point:: 186-187°C
storage temp.: -20°C
solubility: DMF, Ethanol, Hot Ethyl Acetate, Methanol, Pyridine
form: White solid
color: White

More

Less

Safety

Hazard Codes: T
Risk Statements: 20/21/22-37/38-41-36/37/38-25
Safety Statements: 16-26-36/37/39-45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 2

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: L7035
Product name: clasto-Lactacystin β-lactone
Packaging: 0.1mg
Price: $434
Updated: 2024/03/01

Sigma-Aldrich

Product number: 426102
Product name: clasto-Lactacystinβ-Lactone-CAS154226-60-5-Calbiochem
Purity: Ahighlyspecific,cell-permeable,andirreversible20Sproteasomeinhibitor.
Packaging: 100μg
Price: $223.8
Updated: 2024/03/01

Cayman Chemical

Product number: 70988
Product name: Clasto-Lactacystin β-lactone
Purity: ≥95%
Packaging: 50μg
Price: $65
Updated: 2024/03/01

Cayman Chemical

Product number: 70988
Product name: Clasto-Lactacystin β-lactone
Purity: ≥95%
Packaging: 100μg
Price: $124
Updated: 2024/03/01

Cayman Chemical

Product number: 70988
Product name: Clasto-Lactacystin β-lactone
Purity: ≥95%
Packaging: 500μg
Price: $488
Updated: 2024/03/01

More

Less

CLASTO-LACTACYSTIN BETA-LACTONE Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

A cell permeable, irreversible proteasome inhibitor. It is 20-fold more potent than Lactacystin. Lactacytstin spontaneously converts to clasto-lactacystin in biological systems. Clasto-lactacystin is the only cell permeable form of lactacystin. Induces neurite growth and inhibits cell cycle progression similar to lactacytin.

Uses

Clasto-Lactacystin β-lactone has been used as a proteasomal inhibitor.

Uses

clasto-Lactacystin beta-lactone is a 20S proteasome and cathepsin A inhibitor.

Biological Activity

cell-permeable. a highly specific, potent and irreversible proteasome inhibitor. lactacystin (cat. no. 1709-200) acts as a precursor for clasto-lactacystin β-lactone and the latter compound is at least 10 times more active than the parent lactacystin

Biochem/physiol Actions

Clasto-Lactacystin β-lactone (cLβL) is synthesized from lactacystin. It is cell-permeable and cLβL acts on the N-terminal threonine of subunit proteasome β -subunit X It also inhibits 20S proteasome activity in Haloferax volcanii?by acting in the N-threonine residue of the? β -type subunits.

CLASTO-LACTACYSTIN BETA-LACTONE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

CLASTO-LACTACYSTIN BETA-LACTONE Suppliers

Canada 1 China 46 India 1 Switzerland 2 United Kingdom 1 United States 9 Global 60

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
Advantage: 58

ApexBio Technology LLC

Tel: +1-832-696-8203
Fax: +1-832-641-3177
Email: info@apexbt.com
Country: United States
ProdList: 477
Advantage: 60

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51456
Advantage: 80

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57412
Advantage: 58

BOC Sciences

Tel: 16314854226; +16314854226
Email: inquiry@bocsci.com
Country: United States
ProdList: 19741
Advantage: 58

HANGZHOU CLAP TECHNOLOGY CO.,LTD

Tel: 86-571-88216897,88216896 13588875226
Fax: 86-571-88216895
Email: sales@hzclap.com
Country: CHINA
ProdList: 6312
Advantage: 58

DC Chemicals

Tel: 021-58447131 13564518121
Email: sales@dcchemicals.com
Country: China
ProdList: 9409
Advantage: 58

154226-60-5, CLASTO-LACTACYSTIN BETA-LACTONERelated Search:

5-Hydroxymethylpyrrolidin-2-one 2-Methyl-D-serine (2R,3S)-(-)-2-Amino-3-hydroxy-4-methylpentanoic acid Ethyl D-(-)-pyroglutamate (S)-4-Hydroxy-2-pyrrolidinone CIS-3-HYDROXY-DL-PROLINE 2-Oxetanone BETA-BUTYROLACTONE D-Pyroglutamic acid DL-2-ISOBUTYLSERINE LACTACYSTIN dl-3-hydroxynorvaline 2-AMINO-3-HYDROXY-2-METHYLBUTANOIC ACID (2R,4R)-4-METHYL-2-PYROOLIDINE CARBOXYLIC ACID H-ALPHA-ME-D-LEU-OH 3-OXETANAMINE, 3-METHYL- H-ALPHA-ME-D-PRO-OH 3-OXETANAMINE

OMURALIDE

LACTACYSTIN, CLASTO-, BETA-LACTONE

BETA-CLASTOLACTACYSTIN

CLASTO-LACTACYSTIN BETA-LACTONE

1R-[1S-1HYDROXY-2-METHYLPROPYL]-4R-METHYL-6-OXA-2-AZABICYCLO[3.2.0]HEPTANE-3,7-DIONE

clasto-lactacystin β-lactone

Clasto-lactacystin (OMuralide)

(1R,4R,5S)-1-[(1S)-1-Hydroxy-2-Methylpropyl]-4-Methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione

6-Oxa-2-azabicyclo[3.2.0]heptane-3,7-dione, 1-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-, (1R,4R,5S)-

Clasto-Lactacystin β-lactone

154226-60-5

Calpain and Proteasome InhibitorsProteasome, Calpain and Lysosomal Proteases

InhibitorsProtease Inhibitors

Proteasome inhibitor

Proteasome inhibitorEnzyme Inhibitors by Enzyme

Intracellular Protein Degradation

Nitric Oxide and Cell Stress

P to

Protease Inhibitor Specificity Index

Proteasomes

ProteasomeInhibitors

Inhibitors