CLASTO-LACTACYSTIN BETA-LACTONE
- Product Name
- CLASTO-LACTACYSTIN BETA-LACTONE
- CAS No.
- 154226-60-5
- Chemical Name
- CLASTO-LACTACYSTIN BETA-LACTONE
- Synonyms
- OMURALIDE;BETA-CLASTOLACTACYSTIN;Clasto-Lactacystin β-lactone;clasto-lactacystin β-lactone;Clasto-lactacystin (OMuralide);CLASTO-LACTACYSTIN BETA-LACTONE;LACTACYSTIN, CLASTO-, BETA-LACTONE;1R-[1S-1HYDROXY-2-METHYLPROPYL]-4R-METHYL-6-OXA-2-AZABICYCLO[3.2.0]HEPTANE-3,7-DIONE;(1R,4R,5S)-1-[(1S)-1-Hydroxy-2-Methylpropyl]-4-Methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione;6-Oxa-2-azabicyclo[3.2.0]heptane-3,7-dione, 1-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-, (1R,4R,5S)-
- CBNumber
- CB9352564
- Molecular Formula
- C10H15NO4
- Formula Weight
- 213.23
- MOL File
- 154226-60-5.mol
CLASTO-LACTACYSTIN BETA-LACTONE Property
- Melting point:
- 186-187°C
- storage temp.
- -20°C
- solubility
- DMF, Ethanol, Hot Ethyl Acetate, Methanol, Pyridine
- form
- White solid
- color
- White
Safety
- Hazard Codes
- T
- Risk Statements
- 20/21/22-37/38-41-36/37/38-25
- Safety Statements
- 16-26-36/37/39-45
- RIDADR
- UN 2811 6.1 / PGIII
- WGK Germany
- 2
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- L7035
- Product name
- clasto-Lactacystin β-lactone
- Packaging
- 0.1mg
- Price
- $434
- Updated
- 2024/03/01
- Product number
- 426102
- Product name
- clasto-Lactacystinβ-Lactone-CAS154226-60-5-Calbiochem
- Purity
- Ahighlyspecific,cell-permeable,andirreversible20Sproteasomeinhibitor.
- Packaging
- 100μg
- Price
- $223.8
- Updated
- 2024/03/01
- Product number
- 70988
- Product name
- Clasto-Lactacystin β-lactone
- Purity
- ≥95%
- Packaging
- 50μg
- Price
- $65
- Updated
- 2024/03/01
- Product number
- 70988
- Product name
- Clasto-Lactacystin β-lactone
- Purity
- ≥95%
- Packaging
- 100μg
- Price
- $124
- Updated
- 2024/03/01
- Product number
- 70988
- Product name
- Clasto-Lactacystin β-lactone
- Purity
- ≥95%
- Packaging
- 500μg
- Price
- $488
- Updated
- 2024/03/01
CLASTO-LACTACYSTIN BETA-LACTONE Chemical Properties,Usage,Production
Chemical Properties
White Solid
Uses
A cell permeable, irreversible proteasome inhibitor. It is 20-fold more potent than Lactacystin. Lactacytstin spontaneously converts to clasto-lactacystin in biological systems. Clasto-lactacystin is the only cell permeable form of lactacystin. Induces neurite growth and inhibits cell cycle progression similar to lactacytin.
Uses
Clasto-Lactacystin β-lactone has been used as a proteasomal inhibitor.
Uses
clasto-Lactacystin beta-lactone is a 20S proteasome and cathepsin A inhibitor.
Biological Activity
cell-permeable. a highly specific, potent and irreversible proteasome inhibitor. lactacystin (cat. no. 1709-200) acts as a precursor for clasto-lactacystin β-lactone and the latter compound is at least 10 times more active than the parent lactacystin
Biochem/physiol Actions
Clasto-Lactacystin β-lactone (cLβL) is synthesized from lactacystin. It is cell-permeable and cLβL acts on the N-terminal threonine of subunit proteasome β -subunit X It also inhibits 20S proteasome activity in Haloferax volcanii?by acting in the N-threonine residue of the? β -type subunits.