ChemicalBook > CAS DataBase List > CLASTO-LACTACYSTIN BETA-LACTONE

CLASTO-LACTACYSTIN BETA-LACTONE

Product Name
CLASTO-LACTACYSTIN BETA-LACTONE
CAS No.
154226-60-5
Chemical Name
CLASTO-LACTACYSTIN BETA-LACTONE
Synonyms
OMURALIDE;BETA-CLASTOLACTACYSTIN;Clasto-Lactacystin β-lactone;clasto-lactacystin β-lactone;Clasto-lactacystin (OMuralide);CLASTO-LACTACYSTIN BETA-LACTONE;LACTACYSTIN, CLASTO-, BETA-LACTONE;1R-[1S-1HYDROXY-2-METHYLPROPYL]-4R-METHYL-6-OXA-2-AZABICYCLO[3.2.0]HEPTANE-3,7-DIONE;(1R,4R,5S)-1-[(1S)-1-Hydroxy-2-Methylpropyl]-4-Methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione;6-Oxa-2-azabicyclo[3.2.0]heptane-3,7-dione, 1-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-, (1R,4R,5S)-
CBNumber
CB9352564
Molecular Formula
C10H15NO4
Formula Weight
213.23
MOL File
154226-60-5.mol
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CLASTO-LACTACYSTIN BETA-LACTONE Property

Melting point:
186-187°C
storage temp. 
-20°C
solubility 
DMF, Ethanol, Hot Ethyl Acetate, Methanol, Pyridine
form 
White solid
color 
White
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Safety

Hazard Codes 
T
Risk Statements 
20/21/22-37/38-41-36/37/38-25
Safety Statements 
16-26-36/37/39-45
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
2
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
L7035
Product name
clasto-Lactacystin β-lactone
Packaging
0.1mg
Price
$434
Updated
2024/03/01
Sigma-Aldrich
Product number
426102
Product name
clasto-Lactacystinβ-Lactone-CAS154226-60-5-Calbiochem
Purity
Ahighlyspecific,cell-permeable,andirreversible20Sproteasomeinhibitor.
Packaging
100μg
Price
$223.8
Updated
2024/03/01
Cayman Chemical
Product number
70988
Product name
Clasto-Lactacystin β-lactone
Purity
≥95%
Packaging
50μg
Price
$65
Updated
2024/03/01
Cayman Chemical
Product number
70988
Product name
Clasto-Lactacystin β-lactone
Purity
≥95%
Packaging
100μg
Price
$124
Updated
2024/03/01
Cayman Chemical
Product number
70988
Product name
Clasto-Lactacystin β-lactone
Purity
≥95%
Packaging
500μg
Price
$488
Updated
2024/03/01
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CLASTO-LACTACYSTIN BETA-LACTONE Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

A cell permeable, irreversible proteasome inhibitor. It is 20-fold more potent than Lactacystin. Lactacytstin spontaneously converts to clasto-lactacystin in biological systems. Clasto-lactacystin is the only cell permeable form of lactacystin. Induces neurite growth and inhibits cell cycle progression similar to lactacytin.

Uses

Clasto-Lactacystin β-lactone has been used as a proteasomal inhibitor.

Uses

clasto-Lactacystin beta-lactone is a 20S proteasome and cathepsin A inhibitor.

Biological Activity

cell-permeable. a highly specific, potent and irreversible proteasome inhibitor. lactacystin (cat. no. 1709-200) acts as a precursor for clasto-lactacystin β-lactone and the latter compound is at least 10 times more active than the parent lactacystin

Biochem/physiol Actions

Clasto-Lactacystin β-lactone (cLβL) is synthesized from lactacystin. It is cell-permeable and cLβL acts on the N-terminal threonine of subunit proteasome β -subunit X It also inhibits 20S proteasome activity in Haloferax volcanii?by acting in the N-threonine residue of the? β -type subunits.

CLASTO-LACTACYSTIN BETA-LACTONE Preparation Products And Raw materials

Raw materials

Preparation Products

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CLASTO-LACTACYSTIN BETA-LACTONE Suppliers

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154226-60-5, CLASTO-LACTACYSTIN BETA-LACTONERelated Search:

5-Hydroxymethylpyrrolidin-2-one 2-Methyl-D-serine (2R,3S)-(-)-2-Amino-3-hydroxy-4-methylpentanoic acid Ethyl D-(-)-pyroglutamate (S)-4-Hydroxy-2-pyrrolidinone CIS-3-HYDROXY-DL-PROLINE 2-Oxetanone BETA-BUTYROLACTONE D-Pyroglutamic acid DL-2-ISOBUTYLSERINE LACTACYSTIN dl-3-hydroxynorvaline 2-AMINO-3-HYDROXY-2-METHYLBUTANOIC ACID (2R,4R)-4-METHYL-2-PYROOLIDINE CARBOXYLIC ACID H-ALPHA-ME-D-LEU-OH 3-OXETANAMINE, 3-METHYL- H-ALPHA-ME-D-PRO-OH 3-OXETANAMINE

  • OMURALIDE
  • LACTACYSTIN, CLASTO-, BETA-LACTONE
  • BETA-CLASTOLACTACYSTIN
  • CLASTO-LACTACYSTIN BETA-LACTONE
  • 1R-[1S-1HYDROXY-2-METHYLPROPYL]-4R-METHYL-6-OXA-2-AZABICYCLO[3.2.0]HEPTANE-3,7-DIONE
  • clasto-lactacystin β-lactone
  • Clasto-lactacystin (OMuralide)
  • (1R,4R,5S)-1-[(1S)-1-Hydroxy-2-Methylpropyl]-4-Methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione
  • 6-Oxa-2-azabicyclo[3.2.0]heptane-3,7-dione, 1-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-, (1R,4R,5S)-
  • Clasto-Lactacystin β-lactone
  • 154226-60-5
  • Calpain and Proteasome InhibitorsProteasome, Calpain and Lysosomal Proteases
  • InhibitorsProtease Inhibitors
  • Proteasome inhibitor
  • Proteasome inhibitorEnzyme Inhibitors by Enzyme
  • Intracellular Protein Degradation
  • Nitric Oxide and Cell Stress
  • P to
  • Protease Inhibitor Specificity Index
  • Proteasomes
  • ProteasomeInhibitors
  • Inhibitors