TRIACSIN C
- Product Name
- TRIACSIN C
- CAS No.
- 76896-80-5
- Chemical Name
- TRIACSIN C
- Synonyms
- WS1228A;FR-900190;TRIACSIN C;2,4,7-Undecatrienal;Triacsincapprox.90%;Antibiotic WS-1228A;Antibiotic FR-900190;from Streptomyces aureofaciens;2E,4E,7E-undecatriene-1-triazine;triacsin c from streptomyces sp.
- CBNumber
- CB0199054
- Molecular Formula
- C11H17N3O
- Formula Weight
- 207.27
- MOL File
- 76896-80-5.mol
TRIACSIN C Property
- Boiling point:
- 320.7±45.0 °C(Predicted)
- Density
- 0.94±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- methanol: soluble4.90 - 5.10 mg/mL, clear (Pale yellow to yellow)
- form
- Liquid. In DMSO.
- pka
- -0.10±0.70(Predicted)
- color
- clear (Pale yellow to yellow) Solution in DMSO
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions further diluted with DMSO may be stored at -20° for up to 2 months.
Safety
- WGK Germany
- 3
- HS Code
- 29299090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- T4540
- Product name
- Triacsin C from Streptomyces sp.
- Packaging
- 1mg
- Price
- $636
- Updated
- 2024/03/01
- Product number
- 10007448
- Product name
- Triacsin C
- Purity
- ≥95%
- Packaging
- 500μg
- Price
- $287
- Updated
- 2024/03/01
- Product number
- 10007448
- Product name
- Triacsin C
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $515
- Updated
- 2024/03/01
- Product number
- 2472
- Product name
- TriacsinC
- Purity
- ≥95%(HPLC)
- Packaging
- 100U
- Price
- $173
- Updated
- 2021/12/16
- Product number
- 256968
- Product name
- Triacsin C
- Packaging
- 100ug
- Price
- $432
- Updated
- 2021/12/16
TRIACSIN C Chemical Properties,Usage,Production
Description
Triacsin C (76896-80-5) is a long-chain fatty acyl CoA synthetase inhibitor (IC50=3.6-8.7 μM).1?Inhibits mouse macrophage-derived foam cell formation2 and displays anti-atherosclerotic activity3. Cell permeable.
Chemical Properties
Solid
Uses
Triacsin, a fatty acyl CoA synthetase inhibitor, reduces myocardial infarct size, attenuates loss of post-reperfusion cardiac function, increases intravascular nitric oxide (NO) concentration, and inhibits leukocyte recruitment. Triacsin C analogs can also be used as potential antivirals against rotavirus infections.
Definition
ChEBI: Triacsin C is a nitroso compound that is N-undecylnitrous hydrazide carrying double bonds at positions 1,2,4, and 7. It is a long-chain fatty acyl CoA synthetase inhibitor and interferes with lipid metabolism by inhibiting the de novo synthesis of glycerolipids and cholesterol esters. It has a role as an EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor, a vasodilator agent, an apoptosis inhibitor, a bacterial metabolite, an EC 3.1.1.64 (retinoid isomerohydrolase) inhibitor and an antimalarial. It is a nitroso compound, an olefinic compound and a hydrazone.
General Description
Triacsin C belongs to a family of fungal metabolites all having an 11-carbon alkenyl chain with a common N-hydroxytriazene moiety at the terminus.
Biochem/physiol Actions
Triacsin C is a potent inhibitor of long-chain fatty acyl CoA synthetase. It blocks β-cell apoptosis, induced by fatty acids (lipoapoptosis) in a rat model of obesity. In addition, it blocks the de novo synthesis of triglycerides, diglycerides, and cholesterol esters, thus interfering with lipid metabolism.
storage
Store at -20°C
References
1) Hartman et al. (1989), Triacsin C: a differential inhibitor of arachidonoyl-CoA synthetase and nonspecific long chain acyl-CoA synthetase; Prostaglandins, 37 655 2) Namatame et al. (1999), Complete inhibition of mouse macrophage-derived foam cell formation by triacsin C; J. Biochem, 125 319 3) Matsuda et al. (2008), Anti-atherosclerotic activity of triacsin C, an acyl-CoA synthetase inhibitor; J. Antibiot. (Tokyo), 61 318
TRIACSIN C Preparation Products And Raw materials
Raw materials
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