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Nicardipine hydrochloride

Product Name
Nicardipine hydrochloride
CAS No.
54527-84-3
Chemical Name
Nicardipine hydrochloride
Synonyms
YC-93;dafil;dagan;loxen;lincil;Vasonas;Dacarel;Barizin;Aprovan;NICODEL
CBNumber
CB1244267
Molecular Formula
C26H30ClN3O6
Formula Weight
515.99
MOL File
54527-84-3.mol
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Nicardipine hydrochloride Property

Melting point:
176-1780C
storage temp. 
2-8°C
solubility 
DMSO: ~1 mg/mL
form 
powder
color 
yellow
Merck 
14,6495
InChIKey
AIKVCUNQWYTVTO-UHFFFAOYSA-N
CAS DataBase Reference
54527-84-3(CAS DataBase Reference)
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Safety

Hazard Codes 
T
Risk Statements 
23/24/25
Safety Statements 
36/37/39-45
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
US7972100
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
2933399090
Toxicity
LD50 in male, female rats (mg/kg): 634, 557 orally; 18.1, 25.0 i.v.; in male, female mice: 634, 650 orally; 20.7, 19.9 i.v. (Odani, Sado)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H311Toxic in contact with skin

H331Toxic if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P311Call a POISON CENTER or doctor/physician.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P405Store locked up.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
N7510
Product name
Nicardipine hydrochloride
Purity
powder, ≥98%
Packaging
1g
Price
$111
Updated
2021/03/22
Sigma-Aldrich
Product number
PHR2531
Product name
Nicardipine hydrochloride
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
500MG
Price
$199
Updated
2021/03/22
Sigma-Aldrich
Product number
1463224
Product name
Nicardipine hydrochloride
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$366
Updated
2021/03/22
TCI Chemical
Product number
N0635
Product name
Nicardipine Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$108
Updated
2021/03/22
TCI Chemical
Product number
N0635
Product name
Nicardipine Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$315
Updated
2021/03/22
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Nicardipine hydrochloride Chemical Properties,Usage,Production

Chemical Properties

Yellow Solid

Uses

anesthetic (topical)

Uses

Nicardipine is a dihydropyridine L-type calcium channel antagonist that displays antihypertensive and antianginal activity. It is reported to inhibit adenosine A1, A2A, and A3 receptors with Ki values of 19.6, 63.8, and 3.25 μM, respectively, and can inhibit cytochrome P450 3A4 catalytic activity with an IC50 value of 0.148 μM. Additionally, nicardipine has been shown to activate transient receptor potential A1 channels, producing an increase in Ca2+ (EC50 = 0.5 μM).

Uses

Dihydropyridine calcium channel blocker. Antianginal; antihypertensive

brand name

Cardene(PDL Biopharma); Cardene (Roche).

General Description

Nicardipine hydrochloride,1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylicacid methyl 2-[methyl(phenylmethyl)amino]ethylester hydrochloride (Cardene), is a more potent vasodilator ofthe systemic, coronary, cerebral, and renal vasculature andhas been used in the treatment of mild, moderate, and severehypertension. The drug is also used in the management of stableangina.

Safety Profile

Poison by ingestion, intravenous, and intraperitoneal routes. Moderately toxic by subcutaneous route. Human systemic effects: decreased urine volume or anuria. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx an

Nicardipine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Nicardipine hydrochloride Suppliers

Shaanxi Xingbang Pharmaceutical Co., Ltd.
Tel
--
Fax
--
Email
sxxbyy@163.com
Country
China
ProdList
18
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
21-61259100-
Fax
86-21-61259102
Email
sh@meryer.com
Country
China
ProdList
40264
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15877
Advantage
69
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386 / 800-988-0390
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24555
Advantage
81
Energy Chemical
Tel
021-58432009-
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
43499
Advantage
61
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
1938
Advantage
70
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005;021-58099637-8009
Fax
021-58099609
Email
bin.wu@shlschem.com;sales@shlschem.com
Country
China
ProdList
9827
Advantage
59
Nanjing Chemlin Chemical Co., Ltd
Tel
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
20007
Advantage
64
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32358
Advantage
50
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View Lastest Price from Nicardipine hydrochloride manufacturers

Hebei Mojin Biotechnology Co., Ltd
Product
Nicardipine hydrochloride 54527-84-3
Price
US $30.00/drums
Min. Order
1drums
Purity
99%
Supply Ability
20tons
Release date
2021-10-14
Zhuozhou Wenxi import and Export Co., Ltd
Product
Nicardipine hydrochloride 54527-84-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Dideu Industries Group Limited
Product
Nicardipine hydrochloride USP/EP/BP 54527-84-3
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-08-06

54527-84-3, Nicardipine hydrochlorideRelated Search:


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