Nicardipine hydrochloride

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Nicardipine hydrochloride

Product Name: Nicardipine hydrochloride
CAS No.: 54527-84-3
Chemical Name: Nicardipine hydrochloride
Synonyms: YC-93;dafil;dagan;loxen;lincil;Vasonas;Dacarel;Barizin;Aprovan;NICODEL
CBNumber: CB1244267
Molecular Formula: C26H30ClN3O6
Formula Weight: 515.99
MOL File: 54527-84-3.mol

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Nicardipine hydrochloride Property

Melting point:: 176-1780C
storage temp.: 2-8°C
solubility: DMSO: ~1 mg/mL
form: powder
color: yellow
Merck: 14,6495
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in distilled water or ethanol may be stored at -20°C for up to 1 month.
InChIKey: AIKVCUNQWYTVTO-UHFFFAOYSA-N
CAS DataBase Reference: 54527-84-3(CAS DataBase Reference)

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Safety

Hazard Codes: T
Risk Statements: 23/24/25
Safety Statements: 36/37/39-45
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: US7972100
HazardClass: 6.1(b)
PackingGroup: III
HS Code: 2933399090
Toxicity: LD50 in male, female rats (mg/kg): 634, 557 orally; 18.1, 25.0 i.v.; in male, female mice: 634, 650 orally; 20.7, 19.9 i.v. (Odani, Sado)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Precautionary statements: P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: N7510
Product name: Nicardipine hydrochloride
Purity: powder, ≥98%
Packaging: 1g
Price: $132
Updated: 2024/03/01

Sigma-Aldrich

Product number: PHR2531
Product name: Nicardipine hydrochloride
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 500MG
Price: $267
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1463224
Product name: Nicardipine hydrochloride
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200mg
Price: $436
Updated: 2024/03/01

Sigma-Aldrich

Product number: Y0001924
Product name: Nicardipine hydrochloride
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: Y0001924
Price: $148
Updated: 2023/06/20

Sigma-Aldrich

Product number: Y0001917
Product name: Nicardipine for system suitability
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: Y0001917
Price: $201
Updated: 2023/06/20

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Nicardipine hydrochloride Chemical Properties,Usage,Production

Description

Nicardipine is a dihydropyridine L-type calcium channel antagonist that displays antihypertensive and antianginal activity. It is reported to inhibit adenosine A₁, A_2A, and A₃ receptors with K_i values of 19.6, 63.8, and 3.25 μM, respectively, and can inhibit cytochrome P450 3A4 catalytic activity with an IC₅₀ value of 0.148 μM. Additionally, nicardipine has been shown to activate transient receptor potential A1 channels, producing an increase in Ca²⁺ (EC₅₀ = 0.5 μM).

Chemical Properties

Yellow Solid

Uses

anesthetic (topical)

Uses

Nicardipine is a dihydropyridine L-type calcium channel antagonist that displays antihypertensive and antianginal activity. It is reported to inhibit adenosine A1, A2A, and A3 receptors with Ki values of 19.6, 63.8, and 3.25 μM, respectively, and can inhibit cytochrome P450 3A4 catalytic activity with an IC50 value of 0.148 μM. Additionally, nicardipine has been shown to activate transient receptor potential A1 channels, producing an increase in Ca2+ (EC50 = 0.5 μM).

Uses

Dihydropyridine calcium channel blocker. Antianginal; antihypertensive

Definition

ChEBI: Nicardipine hydrochloride is a dihydropyridine. It has a role as a geroprotector.

brand name

Cardene(PDL Biopharma); Cardene (Roche).

General Description

Nicardipine hydrochloride,1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylicacid methyl 2-[methyl(phenylmethyl)amino]ethylester hydrochloride (Cardene), is a more potent vasodilator ofthe systemic, coronary, cerebral, and renal vasculature andhas been used in the treatment of mild, moderate, and severehypertension. The drug is also used in the management of stableangina.

Biochem/physiol Actions

Blocks L-type voltage-dependent calcium channels; antihypertensive.

Clinical Use

Calcium-channel blocker:
Prophylaxis and treatment of angina
Mild to moderate hypertension
Acute life-threatening hypertension and post operative hypertension (IV)

Safety Profile

Poison by ingestion, intravenous, and intraperitoneal routes. Moderately toxic by subcutaneous route. Human systemic effects: decreased urine volume or anuria. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx an

Drug interactions

Potentially hazardous interactions with other drugs
Aminophylline: possibly increases aminophylline concentration.
Anaesthetics: enhanced hypotensive effect.
Antibacterials: metabolism possibly accelerated by rifampicin; metabolism possibly inhibited by clarithromycin, erythromycin and telithromycin.
Antidepressants: enhanced hypotensive effect with MAOIs.
Antiepileptics: effect reduced by carbamazepine, barbiturates, phenytoin and primidone.
Antifungals: metabolism possibly inhibited by itraconazole and ketoconazole; negative inotropic effect possibly increased with itraconazole.
Antihypertensives: enhanced hypotensive effect, increased risk of first dose hypotensive effect of post synaptic alpha-blockers.
Antivirals: concentration possibly increased by ritonavir; use telaprevir with caution.
Cardiac glycosides: digoxin concentration increased.
Ciclosporin: concentration of ciclosporin increased
Grapefruit juice: concentration increased - avoid.
Tacrolimus: may increase tacrolimus levels.
Theophylline: possibly increased theophylline concentration.

Metabolism

Nicardipine is subject to saturable first-pass metabolism. It is extensively metabolised in the liver and excreted in the urine and faeces, mainly as inactive metabolites.

References

1) Merck 14 6495 2) Hulubei et al. (2012), 4-Isoxazolyl-1,4-dihydropyridines exhibit binding at the multidrug-resistance transporter; Bioorg. Med. Chem., 20 6620

Nicardipine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Nicardipine hydrochloride manufacturers

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Product: Nicardipine Hydrochloride 54527-84-3
Price: US $0.00/g
Min. Order: 1g
Purity: More Than 99%
Supply Ability: 100kg/Month
Release date: 2024-10-11

Hebei Weibang Biotechnology Co., Ltd

Product: Nicardipine hydrochloride 54527-84-3
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-28

Hebei Yanxi Chemical Co., Ltd.

Product: Nicardipine hydrochloride 54527-84-3
Price: US $50.00-16.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20 tons
Release date: 2023-09-13

54527-84-3, Nicardipine hydrochlorideRelated Search:

Chlorodimethylphenylsilane Benzyltrimethylammonium chloride Benzyl alcohol Dimethyl carbonate Topotecan hydrochloride 1-AdaMantanethylaMine Benzyl chloride Dimethyl fumarate Dimethyl sulfoxide Dimethyl ether Nicardipine ETHANE Dimethyl sulfate N,N-Dimethylformamide Benzyltriethylammonium chloride Paroxetine hydrochloride Phenylacetone Sibutramine hydrochloride

methyl 2-(benzyl-methyl-amino)ethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride

2-(benzylmethylamino)ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylatemonohydrochloride

Naratriptan HCl

1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid Methyl 2-[Methyl(phenylmethyl)amino]ethyl Ester Hydrochloride

Antagonyl

Barizin

Dacarel

Vasonas

YC-93

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)methyl-2-[methyl(phenylmethyl)amino]-3,5-pyridinedicarboxylic acid ethyl ester hydrochloride

Vasonase

NICARDIPINE HYDROCHLORIDE (YC-93) CALCIU M CHANNEL ANTAG

NICARDIPINE HYDROCHLORIDE MM(CRM STANDARD)

YC-93, 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)methyl-2-[methyl(phenylmethyl)amino]-3,5-pyridinedicarboxylic acid ethyl ester hydrochloride

Aprovan

3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-diMethyl-4-(3-nitrophenyl)-, 3-Methyl 5-[2-[Methyl(phenylMethyl)aMino]ethyl] ester, hydrochloride

3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-methyl 5-[2-[methyl(phenylmethyl)amino]ethyl] ester, hydrochloride (1:1)

5-pyridinedicarboxylicacid,1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-2-(

angioglebil

benzylmethylamino)ethylmethylester,monohydrochloride

bionicard

dafil

dagan

lincil

loxen

nicardil

perdipina

rs-69216

PERDIPINE

NICODEL

NICARDIPINE HCL

NICARDIPINE HYDROCHLORIDE

YC-93 HCL

YC-93 HYDROCHLORIDE

1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-3,5-PYRIDINE-DICARBOXYLIC ACID 3-METHYL ESTER 5-[2-(METHYL-(BENZYL)AMINO)ETHYL] ESTER HYDROCHLORIDE

1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-3,5-PYRIDINEDICARBOXYLIC ACID METHYL 2- [METHYL-(PHENYLMETHYL)AMINO]ETHYL ESTER HYDROCHLORIDE

1,4-DIHYDRO-2,6-DIMETHYL-4-[3-NITROPHENYL]METHYL-2-[METHYL(PHENYLMETHYL)AMINO]-3,5-PYRIDINEDICARBOXYLIC ACID ETHYL ESTER HYDROCHLORIDE

Nicardipine Hydrochloride, 99.0+ % (HPLC)

NicardipineHydrochloride&gt

Nicardipine for system suitability

Nicardipine hydrochloride USP/EP/BP

3-(2-(Benzyl(methyl)amino)ethyl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride

Antagonil, Dagan, Flusemide)

Nicardipine HCl (RS69216

Nicardipine 13CD3 Hydrochloride

Nicardipine HydrochlorideQ: What is Nicardipine Hydrochloride Q: What is the CAS Number of Nicardipine Hydrochloride Q: What is the storage condition of Nicardipine Hydrochloride Q: What are the applications of Nicardipine Hydrochloride

Nicardipine Hydrochloride (1463224)

13C,2H3]-Nicardipine Hydrochloride

Nicardipine Hydrochloride, ≥ 98.0%

2-(Benzylmethylamino)ethylmethyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridin-3,5-dicarboxylatmonohydrochlorid

54527-84-3

5427-84-3

C26H29N3O6HCl

C26H30ClN3O6

C25H28ClN3O6

C26H29N3O6ClH

Inhibitors and Activators

Ion Channels