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Etidronate disodium

Product Name
Etidronate disodium
CAS No.
7414-83-7
Chemical Name
Etidronate disodium
Synonyms
Etidron;sm-5600;Calcimux;Didronel;didronelr;BA 49280E;ETIDRONATE;Sodium etidronate;sodiumethidronate;sodiumethydronate
CBNumber
CB0207300
Molecular Formula
C2H9NaO7P2
Formula Weight
230.02
MOL File
7414-83-7.mol
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Etidronate disodium Property

Melting point:
>300 °C
storage temp. 
15-25°C
solubility 
H2O: 26 mg/mL
form 
solid
color 
white
Water Solubility 
Soluble in water (26 mg/ml).
Merck 
14,3863
Stability:
Hygroscopic
CAS DataBase Reference
7414-83-7
EPA Substance Registry System
Phosphonic acid, (1-hydroxyethylidene)bis-, disodium salt (7414-83-7)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
36/37/39
WGK Germany 
1
RTECS 
SZ8562240
TSCA 
Yes
HS Code 
29319090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P5248
Product name
Etidronate disodium hydrate
Purity
≥97% (NMR), solid
Packaging
10mg
Price
$129
Updated
2024/03/01
Sigma-Aldrich
Product number
1268502
Product name
Etidronate disodium hydrate
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$377
Updated
2022/05/15
TCI Chemical
Product number
D4159
Product name
Disodium Etidronate Hydrate
Purity
>98.0%(T)
Packaging
5g
Price
$179
Updated
2024/03/01
TCI Chemical
Product number
D4159
Product name
Disodium Etidronate Hydrate
Purity
>98.0%(T)
Packaging
25g
Price
$537
Updated
2024/03/01
Alfa Aesar
Product number
J62381
Product name
Etidronate disodium
Packaging
1g
Price
$234.65
Updated
2024/03/01
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Etidronate disodium Chemical Properties,Usage,Production

Description

Agents in the first generation (e.g., etidronate disodium and tiludronate) that were dosed continuously produced poorly mineralized bone, because there was no interval for appropriate bone mineralization to occur. Subsequent studies that used a cyclic dosing schedule (400 mg/day for 2 weeks, followed by 2.5 months of calcium supplementation only) showed improvement in bone mineralization. Etidronate has been approved for treatment of Paget's disease of the bone but not for treatment of osteoporosis. Tiludronate is approximately 10-fold more potent than etidronate and, when given orally for 6 months (200, 400, or 800 mg/day), increases BMD by 2%. No further bone loss was detected in patients 6 months after cessation of therapy.

Chemical Properties

White Crystalline Solid

Originator

Etidron,Gentili,Italy,1977

Uses

Used as a calcium regulator. A bisphosphonate bone resorptive inhibitor

Uses

Etidronate disodium is a bisphosphonate antiresorptive agent,it is used as a calcium regulator.

Uses

progestin

Uses

Sequestering and chelating agent; scale and corrosion inhibitor.

Definition

ChEBI: An organic sodium salt resulting from the replacement of two protons from etidronic acid (one from from each of the phosphonic acid groups) by sodium ions.

Manufacturing Process

Phosphorous acid was premixed with acetic acid to form a 50 wt % solution of phosphorous acid dissolved in acetic acid. The acids were mixed on a molar basis of 1.36:1, acetic acid to phosphorous acid, and this corresponded on a mol percentage basis to 57.6% acetic acid and 42.4% phosphorous acid. Acetic anhydride was continuously metered into a stream of the phosphorous acid-acetic acid mixture to form the reaction solution. The acetic anhydride was metered into the acid mixture at a mol ratio of 1.33 mols of acetic anhydride per mol of phosphorous acid. The metering rates were 18.5 lb/hr of the phosphorous acid/acetic acid premixed solution and 15.1 lb/hr acetic anhydride. The reaction solution was continuously passed through a heat exchanger where it was heated to 190°F then it was continuously fed into a two stage back-mix reaction zone where due to the heat of reaction the temperature rose to 275°F. The average residence in the reaction zone was 27 min. The reaction zone consisted of two back-mix reactors each having a capacity of 7.5 pounds of the reaction solution. A stream of reaction solution was continuously with drawn from the second reactor and continuously mixed with a stream of water which was being metered at a rate of 2 lb/hr. This amount of water corresponded to 18% excess over the theoretical amount necessary to hydrolyze all of the acetyl-containing compounds in the reaction solution to free acids. The hydrolyzed solution was continuously passed through a heat exchanger and cooled to room temperature after which the solution was continuously passed to a crystallizer where, with agitation, the ethane-1-hydroxy-1,1-diphosphonic acid crystallized. The slurry was then filtered and the crystals were recovered and dried. Analysis of the product showed a conversion rate of phosphorous acid to ethane-1-hydroxy-1,1- diphosphonic acid of 86%. Sodium hydroxide may be used to give the disodium salt.

brand name

Didronel (Millot Laboratories, France); Didronel (Procter & Gamble).

Therapeutic Function

Bone calcium regulator

Biochem/physiol Actions

Etidronate helps to guard chronic ocular hypertension prompted retinal oxidative stress. It stimulates the development of retinal ganglion cells through insulin-like growth factor 1 (IGF-1) signaling pathway. It may possess neuroprotective effects in in vivo and in vitro rat model of glaucoma. Etidronate belongs to bisphosphonates.

Safety Profile

Poison by intravenous and subcutaneous routes. Moderately toxic by ingestion. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of POx, and Na2O.

Veterinary Drugs and Treatments

Etidronate is a first generation bisphosphonate that may be useful for the treatment of severe hypercalcemia associated with neoplastic disease. Its use in human medicine has been largely replaced with newer, more potent bisphosphonates that can be dosed less often or have fewer adverse effects. Etidronate is also indicated in humans for the treatment of Paget’s disease and heterotopic ossification (e.g., after total hip replacement).

Etidronate disodium Preparation Products And Raw materials

Raw materials

Preparation Products

water quality stabilizre DDF-1
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Etidronate disodium Suppliers

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View Lastest Price from Etidronate disodium manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Etidronate disodium 7414-83-7
Price
US $30.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-04-30
Sinoway Industrial co., ltd.
Product
Etidronate Disodium 7414-83-7
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
89.8-95.6%
Supply Ability
20TONS
Release date
2024-11-01
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Etidronate disodium 7414-83-7
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
98%min; CP
Supply Ability
1000kg
Release date
2021-09-17

7414-83-7, Etidronate disodiumRelated Search:

Zinc sulphate Iron oxide Ipriflavone FLB 131, S-(-)-3-Chloro-5-ethyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-6-hydroxy-2-methoxybenzamide hydrochloride CLODRONIC ACID Chlorine dioxide Hydroxyethyl starch Trisodium citrate dihydrate Sodium nitrite Ethylenediaminetetraacetic acid disodium salt Sodium chlorate Water treatment disinfectant Phosphonic acid, disodium salt Ethyl phosphite 1-Hydroxyethylidene-1,1-diphosphonic acid Etidronate disodium 1-Hydroxyethanediphosphonic acid sodium salt ETIDRONIC ACID-D3

  • Sodium etidronate
  • didronelr
  • disodium(1-hydroxyethylidene)diphosphonate
  • disodium1-hydroxyethylidenephosphonate
  • disodiumdihydrogen(1-hydroxyethylidene)diphosphonate
  • disodiumethanol-1,1-diphosphonate
  • disodiumethydronate
  • 1-Hydroxyethylidone-1,1-diphosphonicaciddisodiumsalt
  • 1-Hydroxyethylidone-1,1-diphosphonicacidpentasodiumsalt
  • Pentasodiumetidronate
  • 1-Hydroxyethylidone-1,1-diphosphonicacid
  • 1-Hydroxyethylidone-1,1-diphosphonicacidtrisodiumsalt
  • Calcimux
  • Etidron
  • DIPHOSPHONICACID,(1-HYDROXYETHYLENE)-,DISODIUMSALT
  • DIPHOSPHONICACID,(1-HYDROXYETHYLIDENE)-,DISODIUMSALT
  • etidronate disodium，ETD
  • Dinatriumdihydrogen(1-hydroxyethyliden)bisphosphonat
  • 1-Hydroxyethylidene-1,1-bis-(phosphonic acid) disodium salt
  • Phosphonicacid, P,P'-(1-hydroxyethylidene)bis-, sodiuM salt (1:2)
  • DisodiuM of 1-Hydroxy Ethylidene-1,1-Diphosphonic Acid (HEDPNa2)
  • Etidronate Disodium (200 mg)
  • (1-Hydroxyethane-1,1-diyl)diphosphonic acid disodi
  • Didronel
  • disodium hydroxy-[1-hydroxy-1-[hydroxy(oxidanidyl)phosphoryl]ethyl]phosphinate
  • disodium hydroxy-[1-hydroxy-1-[hydroxy(oxido)phosphoryl]ethyl]phosphinate
  • DisodiuM Etidronate Hydrate
  • 1-Hydroxyethane-1,1-diphosphonic Acid DisodiuM Salt
  • BA 49280E
  • DisodiuM (1-Hydroxyethylidene)-1,1-bisphosphonate
  • P,P'-(1-Hydroxyethylidene)bisphosphonic Acid SodiuM Salt
  • Disodium 1-Hydroxyethane-1,1-diphosphonate 1-Hydroxyethane-1,1-diphosphonic Acid Disodium Salt Etidronic Acid Disodium Salt
  • Etidronate disodiuM hydrate
  • DIHYDROGEN (1-HYDROXYETHYLIDENE)BISPHOSPHONATE DISODIUM
  • DISODIUM ETIDRONATE
  • hedp disodium salt
  • ETIDRONATE
  • ETIDRONATE DISODIUM
  • Etidronic acid disodium salt
  • ETRIDRONIC ACID, DISODIUM SALT
  • 1-HYDROXYETHYLIDENE-1,1-DIPHOSPHONIC ACID DISODIUM SALT
  • (1-HYDROXYETHYLIDENE)BISPHONIC ACID
  • (1-HYDROXYETHYLIDENE)BISPHOSPHONIC ACID
  • (1-hydroxyethane-1,1-diyl)diphosphonicaciddisodiumsalt
  • (1-hydroxyethane-1,1-diyl)di-phosphonicacidisodiumsalt
  • (1-hydroxyethylidene)bis-phosphonicacidisodiumsalt
  • (1-hydroxyethylidene)diphosphonicacid,disodiumsalt
  • (1-hydroxyethylidene)di-phosphonicacidisodiumsalt
  • ethane-1-hydroxy-1,1-diphosphonicacid,disodiumsalt
  • Phosphonicacid,(1-hydroxyethylidene)bis-,disodiumsalt
  • sm-5600
  • sodiumethidronate
  • sodiumethydronate
  • ethydronate disodium
  • ETIDRONATE DISODIUM (1-HYDROXYETHYLIDONE-1,1-DIPHOSPHONIC ACID DISODIUM SALT)
  • ETIDRONATE DISODIUM USP(CRM STANDARD)
  • Dihydrogen (1-hydroxyethylidene)bisphosphonate disodium hydrate
  • disodium dihydrogen (1-hydroxyethylidene)bisphosphonate