methyl trimethoxyacetate
- Product Name
- methyl trimethoxyacetate
- CAS No.
- 18370-95-1
- Chemical Name
- methyl trimethoxyacetate
- Synonyms
- methyl 2,2,2-trimethoxyacetate;(MeO)3CCO2Me;methyl trimethoxyacetate;Methyl trimethoxyacetate 96%;TRIMETHOXY-ACETIC ACID METHYL ESTER;2,2,2-Trimethoxyacetic acid methyl ester;Acetic acid, 2,2,2-trimethoxy-, methyl ester
- CBNumber
- CB02077217
- Molecular Formula
- C6H12O5
- Formula Weight
- 164.16
- MOL File
- 18370-95-1.mol
methyl trimethoxyacetate Property
- Boiling point:
- 70 °C(Press: 8 Torr)
- Density
- 1.129 g/mL at 25 °C
- refractive index
- n20/D1.413
- Flash point:
- 82℃
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- liquid
- Appearance
- Colorless to light yellow Liquid
- InChI
- InChI=1S/C6H12O5/c1-8-5(7)6(9-2,10-3)11-4/h1-4H3
- InChIKey
- QTABOWCQAPYNPP-UHFFFAOYSA-N
- SMILES
- C(OC)(=O)C(OC)(OC)OC
N-Bromosuccinimide Price
- Product number
- 738131
- Product name
- Methyl trimethoxyacetate
- Purity
- 96%
- Packaging
- 1g
- Price
- $270
- Updated
- 2025/07/31
- Product number
- M339345
- Product name
- Methyl2,2,2-Trimethoxyacetate
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- X4999
- Product name
- Methyl trimethoxyacetate
- Packaging
- 250mg
- Price
- $97
- Updated
- 2021/12/16
- Product number
- OR918584
- Product name
- Methyl2,2,2-trimethoxyacetate
- Purity
- 95%
- Packaging
- 1g
- Price
- $102
- Updated
- 2021/12/16
- Product number
- 094798
- Product name
- Methyl 2,2,2-trimethoxyacetate
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $152
- Updated
- 2021/12/16
methyl trimethoxyacetate Chemical Properties,Usage,Production
Synthesis
67-56-1
17640-25-4
18370-95-1
Methyl 2,2-dichloro-2-methoxyacetate (50 g, 248.5 mmol, 1 eq.) was added to a 500 mL round bottom flask. The reaction flask was cooled to 0 °C in an ice bath, followed by the slow addition of anhydrous methanol (34.33 g, 745.7 mmol, 44 mL, 3 eq.) over 5 min with stirring. The reaction mixture was immediately diluted with anhydrous ether (150 mL). Maintaining the reaction temperature at 0 °C, anhydrous pyridine (49.10 g, 621.4 mmol, 50.20 mL, 2.5 eq.) was slowly added through a constant pressure dropping funnel over 1 hour. After addition, the reaction mixture was continued to be stirred rapidly at 0 °C for 30 min. Stirring was stopped and the mixture was allowed to stand at room temperature for 72 h. Long white needle-like crystals were observed to form in the solution. The mixture was filtered through a mesoporous glass filter and the collected solid was washed with ether. The filtrate was concentrated by rotary evaporation under reduced pressure to give a light yellow oil. The oily substance was again cooled to 0 °C in an ice bath and pyrrolidine (25 mL) was added dropwise through a constant pressure dropping funnel under rapid stirring over a period of 20 min, at which time the solution rapidly changed to a yellow-orange color. After addition, the mixture was continued stirring at 0 °C for 30 min. Subsequent decompression distillation was carried out to recover unreacted pyrrolidine and ethanol at 40 Torr and 28 °C, and the final target product, methyl 2,2,2-trimethoxyacetate (44 g, 80% yield), was collected at 2 Torr and 58 °C as a colorless liquid. The product was characterized by NMR (400 MHz, DMSO-d6): δ 3.80 (s, 3H), 3.30 (s, 9H). Mass spectrometry (EI) analysis showed a molecular ion peak (M+) of 145, corresponding to the molecular formula C6H15O5.
References
[1] Bulletin of the Korean Chemical Society, 2010, vol. 31, # 4, p. 1064 - 1066
[2] Patent: WO2012/37226, 2012, A1. Location in patent: Page/Page column 125-126
[3] Tetrahedron Letters, 2010, vol. 51, # 2, p. 337 - 339
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View Lastest Price from methyl trimethoxyacetate manufacturers
- Product
- Methyl 2,2,2-trimethoxyacetate 18370-95-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-09