ChemicalBook > CAS DataBase List > trans-Clomiphene Citrate

trans-Clomiphene Citrate

Product Name: trans-Clomiphene Citrate
CAS No.: 7599-79-3
Chemical Name: trans-Clomiphene Citrate
Synonyms: Enclomiphene citrate;Enclomifene citrate;Androxal;Enclomid;Unii-J303A6U9Y6;Clomiphene B citrate;(E)-Clomiphene citrate;tans-clomifene citrate;trans-clomifene citrate;trans-Clomiphene citrate
CBNumber: CB02079569
Molecular Formula: C32H36ClNO8
Formula Weight: 598.09
MOL File: 7599-79-3.mol

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trans-Clomiphene Citrate Property

Melting point:: 143-145°C
storage temp.: Amber Vial, -20°C Freezer
solubility: DMSO (Slightly), Ethyl Acetate (Slightly, Heated, Sonicated)
form: Solid
color: White to Off-White
Stability:: Light Sensitive
InChI: InChI=1S/C26H28ClNO.C6H8O7/c1-3-28(4-2)19-20-29-24-17-15-22(16-18-24)25(21-11-7-5-8-12-21)26(27)23-13-9-6-10-14-23;7-3(8)1-6(13,5(11)12)2-4(9)10/h5-18H,3-4,19-20H2,1-2H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/b26-25+;
InChIKey: PYTMYKVIJXPNBD-BTKVJIOYSA-N
SMILES: Cl/C(/C1C([H])=C([H])C([H])=C([H])C=1[H])=C(\C1C([H])=C([H])C([H])=C([H])C=1[H])/C1C([H])=C([H])C(=C([H])C=1[H])OC([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H].O([H])C(C(=O)O[H])(C([H])([H])C(=O)O[H])C([H])([H])C(=O)O[H]

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H360May damage fertility or the unborn child

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N-Bromosuccinimide Price

TRC

Product number: C587045
Product name: trans-ClomipheneCitrate
Packaging: 10mg
Price: $125
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0018264
Product name: TRANS-EMCLOMIPHENE CITRATE
Purity: 95.00%
Packaging: 1G
Price: $351.75
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0018264
Product name: TRANS-EMCLOMIPHENE CITRATE
Purity: 95.00%
Packaging: 10G
Price: $1166.55
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0018264
Product name: TRANS-EMCLOMIPHENE CITRATE
Purity: 95.00%
Packaging: 100G
Price: $3326.4
Updated: 2021/12/16

DC Chemicals

Product number: DC8177
Product name: Enclomiphenecitrate
Purity: >98%
Packaging: 100mg
Price: $450
Updated: 2021/12/16

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trans-Clomiphene Citrate Chemical Properties,Usage,Production

Chemical Properties

Enclomiphene citrate is chemically an organic citrate with good photoluminescent properties in organic solutions due to the presence of a tristyrene unit in its structure. Due to the presence of a tertiary amine unit in the structure, it is sensitive to oxidants and is easily oxidized by oxidants to the corresponding nitrogen oxides.

Uses

trans-Clomiphene Citrate, stereoisomer of Clomiphene Citrate (C587025), a synthetic estrogen agonist-antagonist. Gonad-stimulating principle.

Toxicology

The effects of the cis and trans isomers of clomiphene citrate on the uterine hexokinase activity of immature ovariectomized rats were studied in long- and short-term experiments. At a dose level of 600 μg/kg, both trans-Clomiphene Citrate and cis-Clomiphene Citrate caused a similar increase in total uterine hexokinase activity observable in 18 hr. When enzyme activity was expressed per g of the uterus (specific activity), significant increases were noted 18 hr after a single injection of trans clomiphene or after 4 daily injections of either isomer. Treatment of these animals with 170-estradiol (5 μg/kg) caused an elevation of both the specific and total hexokinase activities within 18 hr[1].

in vivo

Enclomiphene citrate (subcutaneous injection, 0.25 and 0.5 mg/animal, daily) inhibits spermatogenesis and decreases serum luteinizing hormone (LH) and testosterone levels in intact or castrated rats^[5].
Enclomiphene citrate (oral adminstration, 0.03-3 mg/kg, daily for 90 days) reductes body weight to sham levels, and reduced serum cholesterol^[6].

Animal Model:	21 days-old Charles River male rats^[5]
Dosage:	0.25 and 0.5 mg/animal, daily for 24 days.
Administration:	Subcutaneous injection
Result:	Decreased LH and testosterone levels in the serum.

Animal Model:	OVX (ovariectomy) rat model^[6]
Dosage:	0.03, 1, and 3 mg/kg, daily for 90 days.
Administration:	Oral adminstration
Result:	Reducted body weight to sham levels, and reduced serum cholesterol. Showed dose-dependent effects on the proximal tibia with BMD and BMC approaching posttreatment Sham levels.

References

[1] D L DiPietro, D A Goss, F J Sanders. “Effect of cis and trans isomers of clomiphene citrate on uterine hexokinase activity.” Endocrinology 84 6 (1969): 1404–8.

trans-Clomiphene Citrate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from trans-Clomiphene Citrate manufacturers

LIDE PHARMACEUTICALS LIMITED

Product: trans-Clomiphene Citrate 7599-79-3
Price: US $0.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 1000kg
Release date: 2025-11-11

RongNa Biotechnology Co.,Ltd

Product: trans-Clomiphene Citrate 7599-79-3
Price: US $10.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 99%
Supply Ability: 1 ton
Release date: 2025-08-16

Shaanxi Dideu Medichem Co. Ltd

Product: Enclomiphene citrate 7599-79-3
Price: US $0.00-0.00/G
Min. Order: 10G
Purity: 99%
Supply Ability: 100G 1KG
Release date: 2025-05-20

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7599-79-3

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