2'-Deoxyguanosine monohydrate
- Product Name
- 2'-Deoxyguanosine monohydrate
- CAS No.
- 312693-72-4
- Chemical Name
- 2'-Deoxyguanosine monohydrate
- Synonyms
- DG;DEOXYGUANOSINE-2';5′-Nucleotides &A-2'-DEOXYGUANOSINE;2'-DEOXY-D-GUANOSINE;Adenosine Impurity 16;GUANINE DESOXYRIBOSIDE;2'-DEOXYGUANOSINE USP/EP/BP;2'-Deoxyguanosine monohydrate;2'-Deoxyguanosine monohydrate
- CBNumber
- CB0209021
- Molecular Formula
- C10H15N5O5
- Formula Weight
- 285.26
- MOL File
- 312693-72-4.mol
2'-Deoxyguanosine monohydrate Property
- Melting point:
- >300 °C (dec.)(lit.)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- NH4OH 1 M: 50 mg/mL, clear to very faintly turbid, yellow to brown
- form
- powder
- pka
- pK1:2.5(+1) (25°C,μ=0.1)
- color
- White to Off-White
- BRN
- 39814
- InChI
- InChI=1/C10H13N5O4/c11-10-13-8-7(9(18)14-10)12-3-15(8)6-1-4(17)5(2-16)19-6/h3-6,16-17H,1-2H2,(H3,11,13,14,18)/t4-,5+,6+/s3
- InChIKey
- LZSCQUCOIRGCEJ-FPKZOZHISA-N
- SMILES
- OC[C@H]1O[C@@H](N2C3=C(C(NC(=N3)N)=O)N=C2)C[C@@H]1O |&1:2,4,17,r|
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P403Store in a well-ventilated place.
N-Bromosuccinimide Price
- Product number
- D0901
- Product name
- 2′-Deoxyguanosine monohydrate
- Purity
- powder, BioReagent, suitable for cell culture, 99-100%
- Packaging
- 100mg
- Price
- $148
- Updated
- 2024/03/01
- Product number
- D0901
- Product name
- 2′-Deoxyguanosine monohydrate
- Purity
- powder, BioReagent, suitable for cell culture, 99-100%
- Packaging
- 1g
- Price
- $905
- Updated
- 2024/03/01
- Product number
- J14304
- Product name
- 2'-Deoxyguanosine monohydrate, synthetic, 98+% (dry basis), Affymetrix/USB
- Packaging
- 10g
- Price
- $721.65
- Updated
- 2024/03/01
- Product number
- J60741
- Product name
- 2'-Deoxyguanosine monohydrate
- Purity
- 98+%
- Packaging
- 1g
- Price
- $78.4
- Updated
- 2023/06/20
- Product number
- J60741
- Product name
- 2'-Deoxyguanosine monohydrate
- Purity
- 98+%
- Packaging
- 5g
- Price
- $155
- Updated
- 2023/06/20
2'-Deoxyguanosine monohydrate Chemical Properties,Usage,Production
Description
2''-Deoxyguanosine is a purine nucleoside with diverse biological activities. It inhibits the clonogenic growth of HL-60 and K562 leukemia cells (IC50s = 80 and 100 μM, respectively). 2''-Deoxyguanosine inhibits the growth of MOLT-4 T cells and MGL-8 B cells by 99.8 and 68.3%, respectively, when used at a concentration of 50 μM. It increases the number of binucleated cells, a marker of inhibited cytokinesis, in A. sativum meristems. 2''-Deoxyguanosine (>1 μM) also induces relaxation of precontracted isolated bovine lingual artery.
Chemical Properties
White to Off-White Solid. Soluble in NH4OH 1 M: 50 mg/mL, clear to very faintly turbid.
Uses
2′-Deoxyguanosine monohydrate has been used in stromal cell purification. It has also been used for the quantification of whole cell dNTP (deoxyribonucleotide triphosphate).
Definition
ChEBI: 2'-Deoxyguanosine monohydrate is a purine 2'-deoxyribonucleoside having guanine as the nucleobase. It has a role as a Saccharomyces cerevisiae metabolite, a human metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a purines 2'-deoxy-D-ribonucleoside and a purine 2'-deoxyribonucleoside. It is functionally related to a guanosine.
Application
2′-Deoxyguanosine monohydrate has been used as a nucleoside supplement:
to study its effect on mitochondrial DNA copy number in deoxyguanosine kinase (dguok) mutant zebrafish,
in tissue culture medium for deoxyribonucleotide triphosphate (dNTP) synthesis,
in RPMI (Roswell Park Memorial Institute)-1640 medium to eliminate the endogenous thymocytes.
Biological Functions
lu et al. found that 2'-Deoxyguanosine (2-dG) is a key immune signaling molecule in plant–microbe interactions and that Arabidopsis VENOSA4 (VEN4) is essential for plant immunity. 2-dG is the immunoreactive component in ZhiNengCong (ZNC). This compound induced classical immune responses, including ROS production, allose accumulation and MPKs phosphorylation, and upregulated the expression of plant immunity-associated genes. In addition, 2-dG-induced plant immunity requires salicylic acid (SA) receptor NPR1 (but not SA), ethylene (ET) signaling, pattern-recognition receptors/coreceptors (PRRs/coreceptors) and the ATP receptor P2K1[1]. VEN4 was involved in 2-dG biosynthesis and could convert dGTP to 2-dG.
Biochem/physiol Actions
Deoxyguanosine (dG) is a purine nucleoside that upon sequential phosphorylation (kinases) forms deoxyguanosine triphosphate (dGTP) which is used by DNA polymerases and reverse transcriptases to synthesize DNA(s). Deoxyguanosine is the most electron-rich of the four canonical bases and includes many nucleophilic sites which are susceptible to oxidative damage. This makes deoxyguanosine and its oxidized derivatives useful reagents to study mechanisms of oxidative damage to nucleosides and nucleotides.
References
[1] Chongchong Lu . “Discovery of a novel nucleoside immune signaling molecule 2′-deoxyguanosine in microbes and plants.” Journal of Advanced Research 46 (2023): Pages 1-15.
2'-Deoxyguanosine monohydrate Preparation Products And Raw materials
Raw materials
Preparation Products
2'-Deoxyguanosine monohydrate Suppliers
- Tel
- 025-86506605 13952030024
- Fax
- QQ：24810051
- 13811988123@139.com
- Country
- China
- ProdList
- 24
- Advantage
- 58
- Tel
- 027-59223049 15807102573
- Fax
- 027-84666270
- lj_xxjlbio@163.com
- Country
- China
- ProdList
- 309
- Advantage
- 58
- Tel
- 0371-68865717 13213090566
- firstbio@126.com
- Country
- China
- ProdList
- 15
- Advantage
- 58
- Tel
- 18221553137
- ddwuyu@126.com
- Country
- China
- ProdList
- 823
- Advantage
- 58
- Tel
- 0571-89918262 13357170655
- chenlingwei@hizyme.com
- Country
- China
- ProdList
- 284
- Advantage
- 58
- Tel
- 0571-86236268
- 3762199508@qq.com
- Country
- China
- ProdList
- 41
- Advantage
- 58
- Tel
- 0373-6014999 18937330588
- xxycswsale@163.com
- Country
- China
- ProdList
- 69
- Advantage
- 58
- Tel
- 153-0048-7802 15300487802
- jlin@microbiosyn.com
- Country
- China
- ProdList
- 164
- Advantage
- 58
- Tel
- 010-82848833 400-666-7788
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 021-64757213
- Fax
- 86-21-64700613
- info@hongene.com
- Country
- China
- ProdList
- 672
- Advantage
- 61
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44688
- Advantage
- 61
- Tel
- 025-83697070
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
- ProdList
- 19179
- Advantage
- 64
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42958
- Advantage
- 64
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32321
- Advantage
- 50
- Tel
- Fax
- E-Mail Inquiry
- info@syntechem.com
- Country
- China
- ProdList
- 12984
- Advantage
- 57
- Tel
- 021-51613915-820 13611835272
- Fax
- 021 51613951
- mmwang@sunwaypharm.cn
- Country
- China
- ProdList
- 9734
- Advantage
- 57
- Tel
- 0731-85526065 13308475853
- ivy@hnhbsj.com
- Country
- China
- ProdList
- 4554
- Advantage
- 62
- Tel
- 021-56491756 13512199871
- Fax
- 021-5649-1756
- 2819742715@qq.com
- Country
- China
- ProdList
- 4000
- Advantage
- 55
- Tel
- 021-61551611 13296011611
- Fax
- ＋86 21-50676805
- contact@trustwe.com
- Country
- China
- ProdList
- 9895
- Advantage
- 58
- Tel
- 021-60343070
- Fax
- 021-35122006
- Country
- China
- ProdList
- 12740
- Advantage
- 55
- Tel
- 021-021-33632979 15002134094
- Fax
- 021-33632979
- marketing@targetmol.com
- Country
- China
- ProdList
- 7783
- Advantage
- 58
- Tel
- 021-33632979
- Fax
- 021-34692979
- info@tsbiochem.com
- Country
- China
- ProdList
- 8065
- Advantage
- 58
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 41462
- Advantage
- 60
- Tel
- 027-87465837 19945049750
- Fax
- 027-8777-2287
- sales@finetechnology-ind.com
- Country
- China
- ProdList
- 9648
- Advantage
- 58
- Tel
- 021-61478794
- Fax
- 021-61478794
- sales@hcshhai.com
- Country
- China
- ProdList
- 9793
- Advantage
- 50
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
- Country
- China
- ProdList
- 51456
- Advantage
- 80
- Tel
- 027-59207879 1972026995 18140587686
- Fax
- QQ：1972026995
- sales@3600chem.com
- Country
- China
- ProdList
- 4661
- Advantage
- 55
- Tel
- 0510-88770633 13961738808
- jingyaobiotech@126.com
- Country
- China
- ProdList
- 324
- Advantage
- 55
- Tel
- 010-50973130 4009686088
- 3193328036@qq.com
- Country
- China
- ProdList
- 29785
- Advantage
- 68
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 010-60605840 18892239720
- Fax
- 010-60605840
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 12306
- Advantage
- 58
- Tel
- 027-65526929 15102793023
- Fax
- 027-65526669
- hbhxry@foxmail.com
- Country
- China
- ProdList
- 2006
- Advantage
- 55
- Tel
- 027-83778875 15807197853
- Fax
- 027-83991220
- 15807197853@163.com
- Country
- China
- ProdList
- 4027
- Advantage
- 58
- Tel
- 400-711-5280 86-571-81025280
- Fax
- 86-571-85806285
- sales@molcore.com
- Country
- China
- ProdList
- 9967
- Advantage
- 58
- Tel
- 025-58851090 13611564524
- Fax
- (6)02557626880
- lwan@aikonchem.com
- Country
- China
- ProdList
- 15951
- Advantage
- 58
- Tel
- 400-8210725 18016230971
- Fax
- 021-58955996
- malulu@leyan.com
- Country
- China
- ProdList
- 25004
- Advantage
- 58
- Tel
- 18913822354
- market@geneyan-bio.com
- Country
- China
- ProdList
- 299
- Advantage
- 58
- Tel
- 4009004166/18616739031 18616739031
- 3007523370@qq.com
- Country
- China
- ProdList
- 52693
- Advantage
- 58
- Tel
- 010-010-010-62971590 18548936886
- Fax
- 010-62340519
- jack@oka-vip.com
- Country
- China
- ProdList
- 6897
- Advantage
- 58
- Tel
- 13764598896
- grace8018@163.com
- Country
- China
- ProdList
- 290
- Advantage
- 58
- Tel
- 025-025-51191215 18013836722
- Fax
- 025-51191215
- 2399235533@qq.com
- Country
- China
- ProdList
- 4933
- Advantage
- 58
- Tel
- +86-400-002-6226 +86-13028896684;
- sales@rrkchem.com
- Country
- China
- ProdList
- 57423
- Advantage
- 58
- Tel
- +8615866703830
- figo.gao@foxmail.com
- Country
- China
- ProdList
- 8497
- Advantage
- 58
- Tel
- Country
- China
- ProdList
- 10947
- Advantage
- 58
- Tel
- +86-27-87465837 +8618971612321
- Fax
- 86 27 87772287
- info@finetechnology-ind.com
- Country
- China
- ProdList
- 9639
- Advantage
- 58
- Tel
- +86-0571-86912261 +8613735419629
- sales@newcanbio.com
- Country
- China
- ProdList
- 9981
- Advantage
- 58
- Tel
- +862156762820 +86-13564624040
- sales@myuchem.com
- Country
- China
- ProdList
- 7629
- Advantage
- 58
- Tel
- +8617531190177
- peter@yan-xi.com
- Country
- China
- ProdList
- 5857
- Advantage
- 58
- Tel
- +86-0551-65418684 +8618949823763
- Fax
- 0086-551-65418684
- sales@tnjchem.com
- Country
- China
- ProdList
- 25356
- Advantage
- 58
- Tel
- +8617653113219
- sales01@sdlookchemical.com
- Country
- China
- ProdList
- 2737
- Advantage
- 58
View Lastest Price from 2'-Deoxyguanosine monohydrate manufacturers
- Product
- 2'-Deoxyguanosine 312693-72-4
- Price
- US $1588.00/KG
- Min. Order
- 1Kg/Bag
- Purity
- 99%
- Supply Ability
- 1000KG
- Release date
- 2021-06-07
- Product
- 2'-deoxyguanosine 312693-72-4
- Price
- US $220.00-10.00/kgkg
- Min. Order
- 1kgkg
- Purity
- 0.99
- Supply Ability
- 100
- Release date
- 2023-09-14
- Product
- 2'-deoxyguanosine 312693-72-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-25