ChemicalBook > CAS DataBase List > Candesartan

Candesartan

Product Name
Candesartan
CAS No.
139481-59-7
Chemical Name
Candesartan
Synonyms
Atacend;CV-11974;CILEXITIL;CANDESARTAN;tandishatan;Candesartan M1;Candesartan 98%;Candesartan Base;Candesartan (C8);Candesartan (Atacand)
CBNumber
CB0209324
Molecular Formula
C24H20N6O3
Formula Weight
440.45
MOL File
139481-59-7.mol
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Candesartan Property

Melting point:
183-185°C
Boiling point:
754.8±70.0 °C(Predicted)
Density 
1.41±0.1 g/cm3(Predicted)
RTECS 
DD6671000
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
Soluble in DMSO (up to 40 mg/ml)
pka
2.06±0.10(Predicted)
form 
solid
color 
White
Water Solubility 
Soluble in ethyl acetate, methanol, water (<1 mg/ml at 25°C), DMSO (88 mg/ml at 25°C), and ethanol (1 mg/ml at 25°C).
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
CAS DataBase Reference
139481-59-7(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22-36/37/38
Safety Statements 
26-36-60-36/37-9
HS Code 
29419000
Hazardous Substances Data
139481-59-7(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Alfa Aesar
Product number
J62818
Product name
Candesartan, 98%
Packaging
100mg
Price
$68.1
Updated
2024/03/01
Alfa Aesar
Product number
J62818
Product name
Candesartan, 98%
Packaging
1g
Price
$284.65
Updated
2024/03/01
Tocris
Product number
4791
Product name
Candesartan
Purity
≥98%(HPLC)
Packaging
50
Price
$324
Updated
2021/12/16
Tocris
Product number
4791
Product name
Candesartan
Purity
≥98%(HPLC)
Packaging
10
Price
$75
Updated
2021/12/16
TRC
Product number
C175575
Product name
Candesartan
Packaging
100mg
Price
$65
Updated
2021/12/16
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Candesartan Chemical Properties,Usage,Production

Description

Candesartan (CAS 139481-59-7) is an angiotensin II receptor I (AT1) antagonist, IC50s=1.12 and 2.86 nM for bovine adrenal cortex and rabbit aorta respectively.1?Selectively inhibits angiotensin II-induced contraction of rabbit aortic strips with no effect on contraction induced by other agents such as norepinephrine, KCl, serotonin, PGF2αor endothelin. Prevents astrocyte and microglial activation and neuroinflammation and improves hippocampal neurogenesis.2?Attenuates angiogenesis in hepatocellular carcinoma.3?Clinically useful antihypertensive agent. Ameliorates brain inflammation associated with Alzheimer’s disease.4?Active?in vivo?and orally active.

Chemical Properties

Crystalline Solid

Uses

An angiotensin II type-1 receptor antagonist. Used in treatment of congestive heart failure. Antihypertensive

Uses

antihypertensive, angiotensin II inhibitor

Uses

Candesartan is a selective AT1 (angiotensin II receptor 1) antagonist. Antagonism of angiotensin receptors inhibits vasoconstriction and the production of aldosterone, leading to a decrease in water and sodium concentration in blood plasma. Exhibits antihypertensive effects in animal models. Used in treatment of congestive heart failure, as antihypertensive. Candesartan does not affect cell viability or proliferation but increases the expression of VEGF and interleukin-8 in the cultured medium of KU-19-19 cells. Candesartan (0.1 nM) could reduce the maximal contractile response to angiostensin II by approximately 50%.

Definition

ChEBI: A benzimidazolecarboxylic acid that is 1H-benzimidazole-7-carboxylic acid substituted by an ethoxy group at position 2 and a ({2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl}methyl) group at position 1. It is a angiotensin eceptor antagonist used for the treatment of hypertension.

brand name

Atacand (AstraZeneca).

General Description

Candesartan, (+)-1-[[(cyclohexyloxy)carbonyl]-oxy]ethyl 2- ethoxy-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylate(Atacand), like losartan, possesses the acidic tetrazole system,which most likely plays a role in binding to the angiotensin IIreceptor similarly to the acidic groups of angiotensin II. Also,the imidazole system has been replaced with a benzimidazolepossessing an ester at position. This ester must be hydrolyzedto the free acid. Fortunately, this conversion takesplace fairly easily because of the carbonate in the ester sidechain. This facilitates hydrolysis of the ester so much thatconversion to the free acid takes place during absorption fromthe gastrointestinal tract.

storage

Store at RT

References

1) Shibouta?et al.?(1993),?Pharmacological profile of a highly potent and long-acting angiotension II receptor antagonist, 2-ethoxy-1-[[2’-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazol-7-carboxylic acid (CV-11974), and its prodrug, (+/-)-1-(cyclohexyloxycarbonyloxy)-ethyl 2-ethoxy-1-[[2’-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate (TCV-116); J. Pharmacol. Exp. Therap.,?266?114 2) Bhat?et al. (2017),?Angiotensin receptor Blockade by Inhibiting Glial Activation Promotes Hippocampal Neurogenesis Via Activation of Wnt/B-Catenin signaling in hypertension; Mol. Neurobiol.,?55 5282 3) Fan?et al.?(2016),?Candesartan attenuates angiogenesis in hepatocellular carcinoma via downregulating AT1R/VEGF pathway; Biomed. Pharmacother.,?83?704 4) Torika?et al.?(2018),?Candesartan ameliorates brain inflammation associated with Alzheimer’s disease; CNS Neurosci. Ther.?24?231

Candesartan Preparation Products And Raw materials

Raw materials

Sodium azide Mineral oil Potassium carbonate Trifluoroacetic acid tert-Butanol 3-Nitrophthalic acid Benzyl bromide Thionyl chloride

Preparation Products

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View Lastest Price from Candesartan manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Candesartan 139481-59-7
Price
US $120.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-04-24
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Candesartan 139481-59-7
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
98%min
Supply Ability
500kg
Release date
2021-10-20
Wuhan Circle Star Chem-medical Technology Co.,Ltd
Product
Candesartan 139481-59-7
Price
US $0.00-0.00/g
Min. Order
1g
Purity
98
Supply Ability
1000
Release date
2024-12-20

139481-59-7, CandesartanRelated Search:

METSULFURON METHYL Methyl salicylate Kresoxim-methyl Ethoxyquin PHENYL VALERATE Candesartan Cilexetil DIETHOXYMETHANE Methyl 1-[(2'-cyanobiphenyl-4-yl)methyl]-2-ethoxy-1H-benzimidazole-7-carboxylate Ethyl -2-ethoxy-1-[[(2-(1Htetrazol-5-yl)biphenyl-4-yl-) methyl] Ethyl-2-Ethoxy-1-[[(2'-Cyanobiphenyl-4-yl) Methyl] Benzimidazole]-7-Carboxylate Benzimidazole Tribenuron methyl Thiophanate-methyl TRITYL CANDESARTAN 4-Ethoxyphenol Methyl Telmisartan Irbesartan

  • 1-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)Methyl)-2-ethoxy-1H-benzo[d]iMidazole-7-carboxylic acid
  • 2-ethoxy-3-[[4-[2-(1h-tetrazol-5-yl)phenyl]phenyl]methyl]-3h-benzoimidazole-4-carboxylic acid
  • 3-[[2'-(1H-Tetrazol-5-yl)biphenyl-4-yl]Methyl]-2-ethoxy-3H-benziMidazole-4- carboxylic Acid
  • Candesartan M1
  • 2-ETHOXY1-2(1H-TETRAZOL-5YL)1,1-BIPHENYL)-4-YL)-4-YL)METHYL)1H-BENZIMIDAZOLE-7-CARBOXYLIC ACID
  • Candesartan Cilexetil EP IMpurity G
  • 1-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylic
  • 1H-Benzimidazole-7-carboxylic acid, 2-ethoxy-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-
  • 1-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxy
  • Candesartan Base
  • Candesartan 98%
  • Candesartan (Candesartan Cilexetil impurity G)
  • Candesartan Solution, 1000ppm
  • Candesartan Cilexetil Impurity 7(EP Impurity G)
  • Candesartan Solution, 100ppm
  • 2-ETHOXY-1-[[2'-(1H-TETRAZOL-5-YL)(1,1'-BIPHENYL)-4-YL]METHYL]-1H-BENZIMIDAZOLE-7-CARBOXYLIC ACID
  • Candesartan[CandesartanCilexetilIntermediates]
  • Candesartan ( For Candesartan Cilexetil )
  • CANDESARTAN
  • CV-11974
  • CILEXITIL
  • 2-Ethoxy-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic Acid, CV-11974
  • 2-Ethoxy-1-[2'-(1-triphenylmethyltetrazol-5-yl)-biphenyl-4-yl-methyl]benzimidazole-7-carboxylicacidcyclohexyl-1-chloroethylcarbonate
  • 2-ethoxy-1-[[(2-(1Htetrazol-5-yl)biphenyl-4-yl-) methyl]
  • 2-Ethoxy-3-[[4-[2-(1H-tetrazol-5-yl)phenyl]phenyl]
  • Atacend
  • 2-Ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazol-7-carboxylic acid
  • (±)-2-Ethoxy-1-[[2’-(1H-tetrazol-5-y1)[1，l'-biphenyl]-4-y1]methyl]-1H-benzimidazole-7-earboxylic acid
  • 3-(2'-Cyano-biphenyl-4-ylMethyl)-2-ethoxy-3H-benzoiMidazole-4-carboxylic acid Me
  • 2-ethoxy-1-({4-[2-(1H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}Methyl)-1H-1,3-benzodiazole-7-carboxylic acid
  • Candesartan (Atacand)
  • tandishatan
  • Candesartan Cilexetil EP Impurity G(Candesartan)
  • 2-Ethoxy-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid
  • 2-Ethoxy-1-[[(2′-(1Htetrazol-5-Yl)Biphenyl-4-Yl-) Methyl]Benzimidazole-7-Carboxylic Acid
  • Candesartan (C8)
  • 1-((2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylic acid
  • Candesartan USP/EP/BP
  • Cesartan intermediates
  • Candesartan Impurity -G Candesartan Cilexetil EP Impurity G
  • Candesartan EP Impurity G
  • Candesartan Cilexetil EP Impurity G (Candesartan Acid)
  • High Quality Intermediates Candesartan CAS: 139481-59-7
  • Candesartan (CV 11974)
  • candesartan cilexetil impurity1364
  • CandesartanQ: What is Candesartan Q: What is the CAS Number of Candesartan Q: What is the storage condition of Candesartan Q: What are the applications of Candesartan
  • Candesartan Cilexetil Related Compound G (1-{[2''-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-2-ethoxybe (1087870)
  • Candesartan Cilexetil USP Related Compound G
  • Candesartan Cilexetil Impurity 7(Candesartan Cilexetil EP Impurity G)
  • Candesartan Cilexetil Impurity G
  • 3-((2'-(2H-Tetrazol-5-yl)biphenyl-4-yl)methyl)-2-ethoxy-3H-benzo[d]imidazole-4-carboxylic acid [CS-VII (Acid)
  • 1-((2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylic acid
  • 1-((2'-(1H-Tetrazol-5-yl)-[1,1'-Biphenyl]-4-yl)Methyl)-2-Ethoxy-1H-Benzo[d]iMidazole-7-Carboxylicacid
  • Candesartan in methanol
  • Candesartan Impurity-G
  • 2-ethoxy-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylic acid
  • 2-Ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylic Acid (Candesar
  • Candesartan, 10 mM in DMSO