4-[(E)-2-(4-methoxyphenyl)diazenyl]-1H-pyrazole-3,5-diamine
- Product Name
- 4-[(E)-2-(4-methoxyphenyl)diazenyl]-1H-pyrazole-3,5-diamine
- CAS No.
- 6975-75-3
- Chemical Name
- 4-[(E)-2-(4-methoxyphenyl)diazenyl]-1H-pyrazole-3,5-diamine
- Synonyms
- ILK-IN-3;ILK-IN-3, 10 mM in DMSO;antitumor,Integrin,inhibit,ILK,Inhibitor,ILK IN 3,ILKIN3;1H-Pyrazole-3,5-diamine, 4-[2-(4-methoxyphenyl)diazenyl]-;4-[(E)-2-(4-methoxyphenyl)diazenyl]-1H-pyrazole-3,5-diamine;3-amino-4-[(E)-2-(4-methoxyphenyl)diazenyl]-1H-pyrazol-5-ylamine
- CBNumber
- CB02111670
- Molecular Formula
- C10H12N6O
- Formula Weight
- 232.24
- MOL File
- 6975-75-3.mol
4-[(E)-2-(4-methoxyphenyl)diazenyl]-1H-pyrazole-3,5-diamine Property
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- solubility
- DMSO: 83.33 mg/mL (358.81 mM)
- form
- Solid
- color
- Light yellow to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P363Wash contaminated clothing before reuse.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CS-0104348
- Product name
- ILK-IN-3
- Purity
- 99.57%
- Packaging
- 5mg
- Price
- $250
- Updated
- 2021/12/16
- Product number
- 173325
- Product name
- 3-Amino-4-[(E)-2-(4-methoxyphenyl)diazenyl]-1H-pyrazol-5-ylamine
- Packaging
- 1g
- Price
- $316
- Updated
- 2021/12/16
- Product number
- CS-0104348
- Product name
- ILK-IN-3
- Purity
- 99.57%
- Packaging
- 25mg
- Price
- $700
- Updated
- 2021/12/16
- Product number
- 173325
- Product name
- 3-Amino-4-[(E)-2-(4-methoxyphenyl)diazenyl]-1H-pyrazol-5-ylamine
- Packaging
- 5g
- Price
- $810
- Updated
- 2021/12/16
- Product number
- 173325
- Product name
- 3-Amino-4-[(E)-2-(4-methoxyphenyl)diazenyl]-1H-pyrazol-5-ylamine
- Packaging
- 10g
- Price
- $1170
- Updated
- 2021/12/16
4-[(E)-2-(4-methoxyphenyl)diazenyl]-1H-pyrazole-3,5-diamine Chemical Properties,Usage,Production
Biological Activity
QLT0267 is an orally active, potent and selective integrin-linked kinase (ILK) inhibitor (IC50 = 26 nM; selectivity: >1000-fold over CK2, CSK, DNA-PK, PIM1, PKB/AKT, PKC, >100-fold over ERK1, GSK3β, LCK, PKA, p70S6K, and RSK1/QLT, >10-fold over CDK1/2/5) th at inhibits ILK-dependent cellular signaling (IC50 in 2h = 1 μM against 20 nM EGF-induced pAKT Ser473 phosphorylation in Hth74 cells). QLT0267 treatment causes thyroid cancer cell cycle arrest and apoptosis, leading to anti-proliferation efficacy in cultures (IC50 <6 μM; NPA187, DRO, and K4 cell lines) and in mice in vivo (DRO xenografts-derived tumor growth; 50-100 mg/kg via daily p.o.).
4-[(E)-2-(4-methoxyphenyl)diazenyl]-1H-pyrazole-3,5-diamine Preparation Products And Raw materials
Raw materials
Preparation Products
4-[(E)-2-(4-methoxyphenyl)diazenyl]-1H-pyrazole-3,5-diamine Suppliers
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