ChemicalBook > CAS DataBase List > Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate
Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate
- Product Name
- Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate
- CAS No.
- 161797-99-5
- Chemical Name
- Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate
- Synonyms
- ethyl 2-(4-hydroxyphenyl)-4-Methyl-5-Thiazolecarboxylate;Febuxostat-8;Febuxostat Impurity A-1;3-thiazole-5-carboxylate;ethyl 2-(4-hydroxyphenyl);Intermediates of Febuxostat;Intermediate 2 of non brucite;Febuxostat Desaldehyde Impurity;Ethyl 2-(4-hydroxyphenyl)-4-methyl-1;Febuxostat Descyano Hydroxy Ethyl Ester
- CBNumber
- CB02128586
- Molecular Formula
- C13H13NO3S
- Formula Weight
- 263.31
- MOL File
- 161797-99-5.mol
More
Less
Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Property
- Melting point:
- 180 ºC
- Boiling point:
- 426.8±55.0 °C(Predicted)
- Density
- 1.274
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Very Slightly)
- form
- Solid
- pka
- 8.56±0.15(Predicted)
- color
- Off-White
- CAS DataBase Reference
- 161797-99-5(CAS DataBase Reference)
More
Less
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
More
Less
N-Bromosuccinimide Price
Alfa Aesar
- Product number
- H52223
- Product name
- Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate, 97%
- Packaging
- 1g
- Price
- $110
- Updated
- 2021/12/16
Alfa Aesar
- Product number
- H52223
- Product name
- Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate, 97%
- Packaging
- 5g
- Price
- $439
- Updated
- 2021/12/16
TRC
- Product number
- E918910
- Product name
- Ethyl2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxylate
- Packaging
- 5g
- Price
- $395
- Updated
- 2021/12/16
TRC
- Product number
- E918910
- Product name
- Ethyl2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxylate
- Packaging
- 2.5g
- Price
- $210
- Updated
- 2021/12/16
AK Scientific
- Product number
- X8013
- Product name
- Ethyl2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate
- Packaging
- 100g
- Price
- $316
- Updated
- 2021/12/16
More
Less
Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Chemical Properties,Usage,Production
Uses
Ethyl 2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxylate is used in the synthesis of the major metabolites of Febuxostat (F229000), a xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout. 40-120 mg/day febuxostat was proven effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout.
Synthesis
A mixture of 4-cyanophenol, NaOH, and ethanol was mixed in a pressure bottle while heated to 80° C. Hydrogen sulfide gas was then introduced, and the pressure increased to 30-60 psi until the thioamidation was determined to be complete by HPLC. Without isolating the thioamide product, HCl was added to the bottle until the pH was below 3.5, the H2S gas was removed, and the bottle was placed under a vacuum for 20 minutes at 30-40° C. The reaction was then heated to 70° C, and ethyl 2-chloroacetoacetate(1.1 eq.) was added to the reaction solution. The reaction was mixed under reflux for 2-3 hours, treated with enough H2O to dissolve the NaCl salt in the reaction mixture, cooled to room temperature, treated with enough water to precipitate the product, and the solid was collected by filtration. The precipitate was washed with water and dried at 80° C. with nitrogen bleeding to provide Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate.
Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Suppliers
- Tel
- 199-4188-3835 19941883835
- 746524151@qq.com
- Country
- China
- ProdList
- 53
- Advantage
- 58
- Tel
- 010-82848833 400-666-7788
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 021-20908456
- Fax
- 021-58180499
- sales@BioChemBest.com
- Country
- China
- ProdList
- 6011
- Advantage
- 61
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30132
- Advantage
- 84
- Tel
- 0573-85285100 18627885956
- Fax
- 0573-85285100
- isenchem@163.com
- Country
- China
- ProdList
- 9551
- Advantage
- 66
- Tel
- 400-6009262 16621234537
- Fax
- 021-64823266
- zhangsn@titansci.com
- Country
- China
- ProdList
- 14113
- Advantage
- 59
- Tel
- Country
- China
- ProdList
- 42982
- Advantage
- 64
- Tel
- 15527768850
- 1791901229@qq.com
- Country
- China
- ProdList
- 8849
- Advantage
- 52
- Tel
- 010-82954736 13391601435
- sales@isomersyn.com
- Country
- China
- ProdList
- 3296
- Advantage
- 57
- Tel
- 400 638 7771
- sales@heowns.com
- Country
- China
- ProdList
- 14443
- Advantage
- 57
- Tel
- 0086-755-86198205
- acinfo@aemonchem.com
- Country
- China
- ProdList
- 1937
- Advantage
- 57
- Tel
- 86-531-88280989
- Fax
- 86-531-88280989
- mymail1996@126.com
- Country
- China
- ProdList
- 258
- Advantage
- 55
- Tel
- 0871-65217109 13211707573;
- Fax
- 0871-65215563
- y.liu@mail.biobiopha.com
- Country
- China
- ProdList
- 5654
- Advantage
- 65
- Tel
- 0755-4000505016 13380397412
- Fax
- 0755 28094224
- 3001272453@qq.com
- Country
- China
- ProdList
- 4969
- Advantage
- 50
- Tel
- 010-56645598 13366904824
- Fax
- 01062230033
- bjkaida@163.com
- Country
- China
- ProdList
- 1662
- Advantage
- 59
- Tel
- 13132578992
- Fax
- 022-83718543-802
- sales@accendatech.com
- Country
- China
- ProdList
- 332
- Advantage
- 58
- Tel
- 010-52878169 15701683040
- sales@bjcomparison.com
- Country
- China
- ProdList
- 4689
- Advantage
- 58
- Tel
- 18521735133 18521732826;
- Fax
- 021-50323701
- market@aladdin-e.com
- Country
- China
- ProdList
- 25015
- Advantage
- 65
- Tel
- 0833-6186272、6186278、6170066 18990613291
- Fax
- 0833-5590359
- sales@hongshengpharm.com
- Country
- China
- ProdList
- 58
- Advantage
- 60
- Tel
- +86(0)21 60484900
- Fax
- +86(0)21 60484900
- Country
- China
- ProdList
- 764
- Advantage
- 50
- Tel
- 86-0755-86635001
- Fax
- 86-0755-22642228
- cantotech@126.com
- Country
- China
- ProdList
- 4576
- Advantage
- 55
- Tel
- 021-62960152
- Fax
- 021-52212593
- 934678158@qq.com
- Country
- China
- ProdList
- 9906
- Advantage
- 55
- Tel
- 020-39119399 18927568969
- Fax
- 020-39119999
- isunpharm@qq.com
- Country
- China
- ProdList
- 4428
- Advantage
- 55
- Tel
- +86-10-83386766
- Fax
- +86-10-83386758
- sales@lianben.com
- Country
- China
- ProdList
- 91
- Advantage
- 58
- Tel
- 13971561712, 13995564702, 027-50664929
- Fax
- 027-50664927
- hbeixys2001@163.com
- Country
- China
- ProdList
- 3123
- Advantage
- 55
- Tel
- 15722085254
- Fax
- 022-26358246
- phytochemical@126.com
- Country
- China
- ProdList
- 813
- Advantage
- 55
- Tel
- 021-60549325 18616193163
- Fax
- 021-33250306
- Country
- China
- ProdList
- 4528
- Advantage
- 56
- Tel
- 400-1647117 15221909166
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 41438
- Advantage
- 60
- Tel
- 0371-53732842 15981811963
- Fax
- 0371-86239377
- 1758257485@qq.com
- Country
- China
- ProdList
- 951
- Advantage
- 56
- Tel
- 021-021-56795766
- Fax
- +86-21-56795266
- sales@worldyachem.com
- Country
- China
- ProdList
- 9352
- Advantage
- 58
- Tel
- 0755-0755-66853366 13670046396
- Fax
- 0755-28363542
- sales@chem-strong.com
- Country
- China
- ProdList
- 17981
- Advantage
- 56
- Tel
- 0510-85629785 18013409632
- Fax
- 051085625359
- sales@reading-chemicals.com
- Country
- China
- ProdList
- 15185
- Advantage
- 58
- Tel
- 86-574-27787657
- Fax
- 86-574-27912196
- info@dearchem.com
- Country
- China
- ProdList
- 4619
- Advantage
- 58
- Tel
- 027-59262863 13277907145 3091977954
- Fax
- 027-59420980
- Country
- China
- ProdList
- 4951
- Advantage
- 58
- Tel
- 021-60345187 13671753212
- Fax
- 021-34702061
- lzz841106@aliyun.com
- Country
- China
- ProdList
- 10287
- Advantage
- 55
- Tel
- 021-64609169 18901607656
- Fax
- 021-64609160
- greensnown@163.com
- Country
- China
- ProdList
- 9911
- Advantage
- 50
- Tel
- 025-57018978 18251899859
- Fax
- 025-57018008
- sales@chalf-pharm.com
- Country
- China
- ProdList
- 5945
- Advantage
- 50
- Tel
- +86 (21) 61124340
- Fax
- +86 (21) 6129-4103
- Country
- China
- ProdList
- 9767
- Advantage
- 58
- Tel
- 13585175604 13585175604
- Fax
- +86-25-52261140
- sales@chicopharm.com
- Country
- China
- ProdList
- 498
- Advantage
- 65
- Tel
- 18068075658
- Fax
- -
- sales@chempioneer.com
- Country
- China
- ProdList
- 1811
- Advantage
- 58
- Tel
- 025-87193546 18652950785
- Fax
- 025-87193546
- chemweiao@163.com
- Country
- China
- ProdList
- 9030
- Advantage
- 60
- Tel
- +86 (531) 8099-2215
- Fax
- +86 (531) 8099-2215
- putubio@outlook.com
- Country
- China
- ProdList
- 1261
- Advantage
- 55
- Tel
- 0531-88801869 15562622698
- Fax
- 0531-88801867
- sciencechem@163.com
- Country
- China
- ProdList
- 274
- Advantage
- 55
- Tel
- 025-5276156 18936048580
- chemxilang@163.com
- Country
- China
- ProdList
- 4008
- Advantage
- 58
- Tel
- 19138486554 18582380095
- Fax
- 0575-89298961
- sales@artisbio.com
- Country
- China
- ProdList
- 3015
- Advantage
- 58
- Tel
- 021-58892003
- info@qiaochem.com
- Country
- China
- ProdList
- 5881
- Advantage
- 65
- Tel
- 0311-89250318 031166536426
- Fax
- 4000311741
- master@sjzsdyn.com
- Country
- China
- ProdList
- 3496
- Advantage
- 58
- Tel
- 0531-88110457 15562555968
- info@pharmachemm.com
- Country
- China
- ProdList
- 168
- Advantage
- 58
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 27322
- Advantage
- 60
- Tel
- 02781293128
- orders@biochemsafebuy.com
- Country
- China
- ProdList
- 9934
- Advantage
- 55
More
Less
View Lastest Price from Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate manufacturers
Zibo Hangyu Biotechnology Development Co., Ltd
- Product
- ethyl 2-(4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate 161797-99-5
- Price
- US $70.00-700.00/kg
- Min. Order
- 10kg
- Purity
- 0.99
- Supply Ability
- 20tons
- Release date
- 2023-11-13
hebei hongtan Biotechnology Co., Ltd
- Product
- ethyl 2-(4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate 161797-99-5
- Price
- US $30.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 2000kg
- Release date
- 2024-03-18
PNP Biotech Co. Ltd
- Product
- Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate 161797-99-5
- Price
- US $0.00/kg
- Min. Order
- 25kg
- Purity
- 98%-99%
- Supply Ability
- Inquiry
- Release date
- 2022-10-18
161797-99-5, Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylateRelated Search:
ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate
2-[3-(AMinocarbonyl)-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-thiazolecarboxylic Acid
Febuxostat Descyano Impurity
isopropyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate
2-(4-HYDROXY-PHENYL)-4-METHYL-THIAZOLE-5-CARBOXYLIC ACID
FeBuxostat Impurity 18
2-[3-Carboxy-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-thiazolecarboxylic Acid
Febuxostat Impurity 8
Methyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate
Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate
Febuxostat
Ethyl 2-(3-Cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate
3-Cyano-4-(2-methylpropoxy)benzenecarbothioamide
Ethyl 2-(3-bromo-4-isobutoxyphenyl)- 4-methyl-5-thiazolecarboxylate
4-HYDROXYTHIOBENZAMIDE
ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate
ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE
4-Methylthiazole