4-Hydroxythiobenzamide

Uses

Product Name: 4-Hydroxythiobenzamide
CAS No.: 25984-63-8
Chemical Name: 4-Hydroxythiobenzamide
Synonyms: 4-hydroxybenzothioamide;HydroxythiobenzaMide;p-HydroxyThioBenzamide;Febuxostat Intermediate;Benzenecarbothioamide, 4-hydroxy-;Febuxostat-22;4-hydroxy thiobenzam;4-HYDROXYTHIOBENZAMIDE;5-HydroxythiobenzaMide;4-Hydroxythiobenzamied
CBNumber: CB1314575
Molecular Formula: C7H7NOS
Formula Weight: 153.2
MOL File: 25984-63-8.mol

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4-Hydroxythiobenzamide Property

Melting point:: 181-185℃
Boiling point:: 320.4±44.0 °C(Predicted)
Density: 1.338±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 9.24±0.26(Predicted)
color: Light Yellow
InChI: InChI=1S/C7H7NOS/c8-7(10)5-1-3-6(9)4-2-5/h1-4,9H,(H2,8,10)
InChIKey: VDTNKXSVUGXUOJ-UHFFFAOYSA-N
SMILES: C1(C(N)=S)=CC=C(O)C=C1
CAS DataBase Reference: 25984-63-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 20/21/22-36/37/38-43-22
Safety Statements: 26-36/37/39-36/37
HS Code: 29242990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: H1308
Product name: 4-Hydroxythiobenzamide
Purity: >98.0%(HPLC)(N)
Packaging: 5g
Price: $39
Updated: 2025/07/31

TCI Chemical

Product number: H1308
Product name: 4-Hydroxythiobenzamide
Purity: >98.0%(HPLC)(N)
Packaging: 25g
Price: $154
Updated: 2025/07/31

TRC

Product number: H807820
Product name: 4-Hydroxythiobenzamide
Packaging: 25g
Price: $205
Updated: 2021/12/16

Matrix Scientific

Product number: 071923
Product name: 4-Hydroxythiobenzamide
Purity: 95+%
Packaging: 25g
Price: $178
Updated: 2021/12/16

AK Scientific

Product number: I350
Product name: 4-Hydroxythiobenzamide
Packaging: 1kg
Price: $334
Updated: 2021/12/16

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4-Hydroxythiobenzamide Chemical Properties,Usage,Production

Uses

4-Hydroxythiobenzamide(25984-63-8) is used in the synthesis of PPARα agonists used in increasing HDLc levels. Also used in the synthesis of potent CDK5 inhibitors in the treatment of Alzheimer’s disease.

Chemical Properties

4-Hydroxythiobenzamide has an appearance ranging from light orange to yellow to green, powder to crystalline, melting point 192 °C, soluble in methanol.

Uses

febuxostat intermediate

Uses

4-Hydroxythiobenzamide is used in the synthesis of PPARα agonists used in increasing HDLc levels. Also used in the synthesis of potent CDK5 inhibitors in the treatment of Alzheimer’s disease.

Synthesis

4-Hydroxythiobenzamide is an important intermediate of Febuxostat, a new anti-gout drug. A patent discloses a method for preparing p-hydroxythiobenzamide. Specifically, a certain amount of water, p-cyanophenol, sodium hydrosulfide, and secondary amine are mixed evenly. At a specific temperature, an organic weak acid is added dropwise. After the reaction is completed, the mixture is filtered, and the filter cake is dried to obtain 4-Hydroxythiobenzamide.

References

[1] Patent: US2005/75503, 2005, A1. Location in patent: Page/Page column 3
[2] Patent: US2012/78013, 2012, A1. Location in patent: Page/Page column 4
[3] Patent: CN106928108, 2017, A. Location in patent: Paragraph 0043; 0044; 0046; 0048; 0063; 0065; 0067; 0071
[4] Patent: WO2016/46836, 2016, A2. Location in patent: Page/Page column 3
[5] Synthetic Communications, 2000, vol. 30, # 6, p. 1083 - 1094

4-Hydroxythiobenzamide Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Hydroxythiobenzamide Suppliers

Americas 1 Belgium 1 Canada 1 China 456 Europe 1 France 1 Germany 8 India 32 Japan 2 South Korea 1 Switzerland 1 The Netherlands 1 United Kingdom 14 United States 40 Global 560

Hubei jian chu biological technology co., LTD

Tel: 027-65528353 13554206703
Email: HBJC3279834739@foxmail.com
Country: China
ProdList: 1009
Advantage: 58

Jinan Lide Pharmaceutical Technology Co., Ltd.

Tel: 0531-68654990 18560195202
Fax: 053168654990
Email: leadgxm@leadchem.net
Country: China
ProdList: 174
Advantage: 58

Zhengzhou Jingjiang Chemical Co. LTD

Tel: 15238060619
Email: liucunjiang_11@163.com
Country: China
ProdList: 43
Advantage: 58

Lianyungang Xuanyuan Chemical Co., Ltd

Tel: 0518-85415818; 18000194506
Email: 2818153737@qq.com
Country: China
ProdList: 48
Advantage: 58

Hubei Hongxin Ruiyu Fine Chemical Co., Ltd.

Tel: 027-027-65385071 17771822910
Fax: 027-65526669
Email: shelleyl.meng@foxmail.com
Country: China
ProdList: 2354
Advantage: 58

Hubei Yiling Biological Co., Ltd.

Tel: 027-65528557 18062592570
Email: hxry2025cc@foxmail.com
Country: China
ProdList: 1126
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

future industrial shanghai co., ltd

Tel: 400-0066400 13621662912
Fax: 021-55660885
Email: sales@jonln.com
Country: China
ProdList: 1995
Advantage: 65

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

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View Lastest Price from 4-Hydroxythiobenzamide manufacturers

Anhuyan (Hainan) Biotechnology Co., LTD

Product: 4-Hydroxythiobenzamide 25984-63-8
Price: US $0.00-0.00/kg
Min. Order: 0.001kg
Purity: 99%
Supply Ability: 2000000kg
Release date: 2025-06-16

Anhuyan (Hainan) Biotechnology Co., LTD

Product: 4-Hydroxythiobenzamide 25984-63-8
Price: US $0.00/G/KG
Min. Order: 1G/KG
Purity: 99%
Supply Ability: 100MT
Release date: 2025-04-23

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 4-Hydroxythiobenzamide 25984-63-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%min
Supply Ability: 1000kg
Release date: 2022-07-21

25984-63-8, 4-HydroxythiobenzamideRelated Search:

ethyl 2-(4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate Febuxostat 4-HYDROXYTHIOBENZAMIDE 4-METHOXYTHIOBENZAMIDE 2,3-DIHYDRO-1,4-BENZODIOXINE-6-CARBOTHIOAMIDE 6,7-DIMETHOXY-1,2,3,4-TETRAHYDROISOQUINOLINE-1-THIONE Tritiozine Vanitiolide 4-Ethoxybenzenecarbothioamide Benzamide THIOBENZAMIDE 4-[5-(TRIFLUOROMETHYL)PYRID-2-YLOXY]THIOBENZAMIDE 4-METHOXY-3-NITROBENZENE-1-CARBOTHIOAMIDE 2,3-DIHYDROBENZO[B]FURAN-5-CARBOTHIOAMIDE 1,3-BENZODIOXOLE-5-CARBOTHIOAMIDE 1-BENZYL-3-(TERT-BUTYL)-1H-PYRAZOLE-5-CARBOXYLIC ACID

4-HYDROXYTHIOBENZAMIDE

p-HydroxyThioBenzamide

4-hydroxybenzothioamide

4-HYDROXY THIOBENZAMIDE 98.0%MIN

4-Hydroxy Thiobenzamide p-Hydroxy Thiobenzamide

4-[amino(sulfanyl)methylidene]cyclohexa-2,5-dien-1-one

Febuxostat Intermediate

Febuxostat-22

4-Hydroxythiobenzamide 4-Hydroxybenzene-1-carbothioamide

4-Hydroxybenzene-1-carbothioamide

4-hydroxy thiobenzam

HydroxythiobenzaMide

4-HYDROXYTHIOBENZAMIDE 4-Hydroxy ThiobenzaMide p-Hydroxy ThiobenzaMide p-HydroxyThioBenzaMide 4-hydroxybenzothioaMide

5-HydroxythiobenzaMide

4-Hydroxythiobenzamide&gt

Benzenecarbothioamide, 4-hydroxy-

Febuxostat intermediates，4-Hydroxythiobenzamide

4-Hydroxythiobenzamide CAS 25984-63-8

4-Hydroxythiobenzamied

4-hydroxy-3-nitrobenzenecarbothioamide

4-Hydroxythiobenzamide 25984-63-8 Pharmaceutical Intermediates ,Pharmaceutical Raw Material

1/4-hydroxythiobenzamide, an intermediate of fepristone

4-Hydroxythiobenzamide (F1)

25984-63-8

29584-63-8

256984-63-8

25984-36-8

C7H8NOS

C7H7NOS

Febuxostat Intermediates

Febuxostat intermediate

chemical additive

pharmaceutical intermediate

25984-63-8