ChemicalBook > CAS DataBase List > Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate

Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate

Product Name
Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate
CAS No.
161797-99-5
Chemical Name
Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate
Synonyms
ethyl 2-(4-hydroxyphenyl)-4-Methyl-5-Thiazolecarboxylate;Febuxostat-8;Febuxostat Impurity A-1;3-thiazole-5-carboxylate;ethyl 2-(4-hydroxyphenyl);Intermediates of Febuxostat;Intermediate 2 of non brucite;Febuxostat Desaldehyde Impurity;Ethyl 2-(4-hydroxyphenyl)-4-methyl-1;Febuxostat Descyano Hydroxy Ethyl Ester
CBNumber
CB02128586
Molecular Formula
C13H13NO3S
Formula Weight
263.31
MOL File
161797-99-5.mol
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Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Property

Melting point:
180 ºC
Boiling point:
426.8±55.0 °C(Predicted)
Density 
1.274
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Very Slightly)
form 
Solid
pka
8.56±0.15(Predicted)
color 
Off-White
InChI
InChI=1S/C13H13NO3S/c1-3-17-13(16)11-8(2)14-12(18-11)9-4-6-10(15)7-5-9/h4-7,15H,3H2,1-2H3
InChIKey
LOCYSKNNFCGDTR-UHFFFAOYSA-N
SMILES
S1C(C(OCC)=O)=C(C)N=C1C1=CC=C(O)C=C1
CAS DataBase Reference
161797-99-5(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Alfa Aesar
Product number
H52223
Product name
Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate, 97%
Packaging
1g
Price
$110
Updated
2021/12/16
Alfa Aesar
Product number
H52223
Product name
Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate, 97%
Packaging
5g
Price
$439
Updated
2021/12/16
TRC
Product number
E918910
Product name
Ethyl2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxylate
Packaging
5g
Price
$395
Updated
2021/12/16
TRC
Product number
E918910
Product name
Ethyl2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxylate
Packaging
2.5g
Price
$210
Updated
2021/12/16
AK Scientific
Product number
X8013
Product name
Ethyl2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate
Packaging
100g
Price
$316
Updated
2021/12/16
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Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Chemical Properties,Usage,Production

Uses

Ethyl 2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxylate is used in the synthesis of the major metabolites of Febuxostat (F229000), a xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout. 40-120 mg/day febuxostat was proven effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout.

Synthesis

A mixture of 4-cyanophenol, NaOH, and ethanol was mixed in a pressure bottle while heated to 80° C. Hydrogen sulfide gas was then introduced, and the pressure increased to 30-60 psi until the thioamidation was determined to be complete by HPLC. Without isolating the thioamide product, HCl was added to the bottle until the pH was below 3.5, the H2S gas was removed, and the bottle was placed under a vacuum for 20 minutes at 30-40° C. The reaction was then heated to 70° C, and ethyl 2-chloroacetoacetate(1.1 eq.) was added to the reaction solution. The reaction was mixed under reflux for 2-3 hours, treated with enough H2O to dissolve the NaCl salt in the reaction mixture, cooled to room temperature, treated with enough water to precipitate the product, and the solid was collected by filtration. The precipitate was washed with water and dried at 80° C. with nitrogen bleeding to provide Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate.

Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Suppliers

SuZhou Yumed Pharmaceutical Technology Co.,Ltd
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199-5111-2435 19951112435
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qibuxiang@163.com
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China
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J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
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86-10-82849933
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jkinfo@jkchemical.com
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China
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Chembest Research Laboratories Limited
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+86-21-20908456
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021-58180499
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sales@BioChemBest.com
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China
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Alfa Aesar
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400-6106006
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021-67582001/03/05
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saleschina@alfa-asia.com
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China
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30123
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Jia Xing Isenchem Co.,Ltd
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0573-85285100 18627885956
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0573-85285100
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isenchem@163.com
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China
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Pure Chemistry Scientific Inc.
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001-857-928-2050 or 1-888-588-9418
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001-617-206-9595
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sales@chemreagents.com
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United States
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021-64823266
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chenyj@titansci.com
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Shanghai Hanhong Scientific Co.,Ltd.
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021-54306202 13764082696
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China
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XiaoGan ShenYuan ChemPharm co,ltd
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15527768850
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1791901229@qq.com
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China
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Beijing Isomersyn Technology CO;LTD
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010-82954736 13391601435
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View Lastest Price from Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate manufacturers

hebei hongtan Biotechnology Co., Ltd
Product
ethyl 2-(4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate 161797-99-5
Price
US $30.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000kg
Release date
2024-05-13
Hebei Chuanghai Biotechnology Co,.LTD
Product
Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate 161797-99-5
Price
US $5.00-2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000kg
Release date
2024-08-20
ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Febuxostat Impurity 8 161797-99-5
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
98%
Supply Ability
500mg
Release date
2024-07-10

161797-99-5, Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylateRelated Search:


  • ethyl 2-(4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate
  • Ethyl 2-(4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate
  • 2-(4-hydroxyphenyl)-4-Methyl-5-Thiazolecarboxylicacid ethyl ester
  • 5-Thiazolecarboxylic acid, 2-(4-hydroxyphenyl)-4-Methyl-, ethyl ester
  • Intermediates of Febuxostat
  • ethyl 2-(4-hydroxyphenyl)-4-Methyl-5-Thiazolecarboxylate
  • Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Ethyl 2-(4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate
  • 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate
  • Febuxostat Descyano Hydroxy Ethyl Ester
  • 3-thiazole-5-carboxylate
  • Ethyl 2-(4-hydroxyphenyl)-4-methyl-1
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  • Febuxostat Impurity, Ethyl 2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxylate (G)
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  • Febuxostat-8
  • Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Ethyl 2-
  • ethyl 2-(4-hydroxyphenyl)-4-methyl thiazole-5-carb
  • Ethyl2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate,97%
  • Febuxostat intermediates,Ethyl 2-(4-hydroxyphenyl)-4- methylthiazole-5-carboxylate
  • CAS 161797-99-5 2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxytic acid ethyl
  • Febuxostat Desaldehyde Impurity
  • ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate 2-
  • ethyl 4-methyl-2-(4-oxocyclohexa-2,5-dien-1-ylidene)-3H-1,3-thiazole-5-carboxylate
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  • Febuxostat intermediate