4-Hydroxythiobenzamide
Uses- Product Name
- 4-Hydroxythiobenzamide
- CAS No.
- 25984-63-8
- Chemical Name
- 4-Hydroxythiobenzamide
- Synonyms
- 4-hydroxybenzothioamide;HydroxythiobenzaMide;p-HydroxyThioBenzamide;Febuxostat Intermediate;Benzenecarbothioamide, 4-hydroxy-;Febuxostat-22;4-hydroxy thiobenzam;4-HYDROXYTHIOBENZAMIDE;5-HydroxythiobenzaMide;4-Hydroxythiobenzamied
- CBNumber
- CB1314575
- Molecular Formula
- C7H7NOS
- Formula Weight
- 153.2
- MOL File
- 25984-63-8.mol
4-Hydroxythiobenzamide Property
- Melting point:
- 181-185℃
- Boiling point:
- 320.4±44.0 °C(Predicted)
- Density
- 1.338±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 9.24±0.26(Predicted)
- color
- Light Yellow
- InChI
- InChI=1S/C7H7NOS/c8-7(10)5-1-3-6(9)4-2-5/h1-4,9H,(H2,8,10)
- InChIKey
- VDTNKXSVUGXUOJ-UHFFFAOYSA-N
- SMILES
- C1(C(N)=S)=CC=C(O)C=C1
- CAS DataBase Reference
- 25984-63-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 20/21/22-36/37/38-43-22
- Safety Statements
- 26-36/37/39-36/37
- HS Code
- 29242990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- H1308
- Product name
- 4-Hydroxythiobenzamide
- Purity
- >98.0%(HPLC)(N)
- Packaging
- 5g
- Price
- $33
- Updated
- 2024/03/01
- Product number
- H1308
- Product name
- 4-Hydroxythiobenzamide
- Purity
- >98.0%(HPLC)(N)
- Packaging
- 25g
- Price
- $132
- Updated
- 2024/03/01
- Product number
- H32780
- Product name
- 4-Hydroxythiobenzamide, 98%
- Packaging
- 5g
- Price
- $98.65
- Updated
- 2024/03/01
- Product number
- H32780
- Product name
- 4-Hydroxythiobenzamide, 98%
- Packaging
- 25g
- Price
- $320.65
- Updated
- 2024/03/01
- Product number
- H807820
- Product name
- 4-Hydroxythiobenzamide
- Packaging
- 25g
- Price
- $205
- Updated
- 2021/12/16
4-Hydroxythiobenzamide Chemical Properties,Usage,Production
Uses
4-Hydroxythiobenzamide(25984-63-8) is used in the synthesis of PPARα agonists used in increasing HDLc levels. Also used in the synthesis of potent CDK5 inhibitors in the treatment of Alzheimer’s disease.
Chemical Properties
4-Hydroxythiobenzamide has an appearance ranging from light orange to yellow to green, powder to crystalline, melting point 192 °C, soluble in methanol.
Uses
febuxostat intermediate
Uses
4-Hydroxythiobenzamide is used in the synthesis of PPARα agonists used in increasing HDLc levels. Also used in the synthesis of potent CDK5 inhibitors in the treatment of Alzheimer’s disease.
Synthesis
4-Hydroxythiobenzamide is an important intermediate of Febuxostat, a new anti-gout drug. A patent discloses a method for preparing p-hydroxythiobenzamide. Specifically, a certain amount of water, p-cyanophenol, sodium hydrosulfide, and secondary amine are mixed evenly. At a specific temperature, an organic weak acid is added dropwise. After the reaction is completed, the mixture is filtered, and the filter cake is dried to obtain 4-Hydroxythiobenzamide.
4-Hydroxythiobenzamide Preparation Products And Raw materials
Raw materials
Preparation Products
4-Hydroxythiobenzamide Suppliers
- Tel
- 800-4238616
- Fax
- +1-888-520-1075 / +1-503-283-1987
- sales@tciamerica.com
- Country
- Americas
- ProdList
- 23653
- Advantage
- 75
View Lastest Price from 4-Hydroxythiobenzamide manufacturers
- Product
- 4-HYDROXYTHIOBENZAMIDE 25984-63-8
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 ton
- Release date
- 2024-12-16
- Product
- 4-Hydroxythiobenzamide 25984-63-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20Tons
- Release date
- 2024-12-11
- Product
- 4-Hydroxythiobenzamide 25984-63-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%min
- Supply Ability
- 1000kg
- Release date
- 2022-07-21