Uses
ChemicalBook > CAS DataBase List > 4-Hydroxythiobenzamide

4-Hydroxythiobenzamide

Uses
Product Name
4-Hydroxythiobenzamide
CAS No.
25984-63-8
Chemical Name
4-Hydroxythiobenzamide
Synonyms
4-hydroxybenzothioamide;HydroxythiobenzaMide;p-HydroxyThioBenzamide;Febuxostat Intermediate;Benzenecarbothioamide, 4-hydroxy-;Febuxostat-22;4-hydroxy thiobenzam;4-HYDROXYTHIOBENZAMIDE;5-HydroxythiobenzaMide;4-Hydroxythiobenzamied
CBNumber
CB1314575
Molecular Formula
C7H7NOS
Formula Weight
153.2
MOL File
25984-63-8.mol
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4-Hydroxythiobenzamide Property

Melting point:
181-185℃
Boiling point:
320.4±44.0 °C(Predicted)
Density 
1.338±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
9.24±0.26(Predicted)
color 
Light Yellow
InChI
InChI=1S/C7H7NOS/c8-7(10)5-1-3-6(9)4-2-5/h1-4,9H,(H2,8,10)
InChIKey
VDTNKXSVUGXUOJ-UHFFFAOYSA-N
SMILES
C1(C(N)=S)=CC=C(O)C=C1
CAS DataBase Reference
25984-63-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
20/21/22-36/37/38-43-22
Safety Statements 
26-36/37/39-36/37
HS Code 
29242990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
H1308
Product name
4-Hydroxythiobenzamide
Purity
>98.0%(HPLC)(N)
Packaging
5g
Price
$33
Updated
2024/03/01
TCI Chemical
Product number
H1308
Product name
4-Hydroxythiobenzamide
Purity
>98.0%(HPLC)(N)
Packaging
25g
Price
$132
Updated
2024/03/01
Alfa Aesar
Product number
H32780
Product name
4-Hydroxythiobenzamide, 98%
Packaging
5g
Price
$98.65
Updated
2024/03/01
Alfa Aesar
Product number
H32780
Product name
4-Hydroxythiobenzamide, 98%
Packaging
25g
Price
$320.65
Updated
2024/03/01
TRC
Product number
H807820
Product name
4-Hydroxythiobenzamide
Packaging
25g
Price
$205
Updated
2021/12/16
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4-Hydroxythiobenzamide Chemical Properties,Usage,Production

Uses

4-Hydroxythiobenzamide(25984-63-8) is used in the synthesis of PPARα agonists used in increasing HDLc levels. Also used in the synthesis of potent CDK5 inhibitors in the treatment of Alzheimer’s disease.

Chemical Properties

4-Hydroxythiobenzamide has an appearance ranging from light orange to yellow to green, powder to crystalline, melting point 192 °C, soluble in methanol.

Uses

febuxostat intermediate

Uses

4-Hydroxythiobenzamide is used in the synthesis of PPARα agonists used in increasing HDLc levels. Also used in the synthesis of potent CDK5 inhibitors in the treatment of Alzheimer’s disease.

Synthesis

4-Hydroxythiobenzamide is an important intermediate of Febuxostat, a new anti-gout drug. A patent discloses a method for preparing p-hydroxythiobenzamide. Specifically, a certain amount of water, p-cyanophenol, sodium hydrosulfide, and secondary amine are mixed evenly. At a specific temperature, an organic weak acid is added dropwise. After the reaction is completed, the mixture is filtered, and the filter cake is dried to obtain 4-Hydroxythiobenzamide.

4-Hydroxythiobenzamide Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Hydroxythiobenzamide Suppliers

Americas 1 Belgium 1 Canada 1 China 451 Europe 1 France 1 Germany 8 India 31 Japan 2 South Korea 1 Switzerland 1 The Netherlands 1 United Kingdom 14 United States 40 Global 554
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28387
Advantage
80
Fine Corporation
Tel
--
Fax
--
Email
info@fine-c.jp
Country
Japan
ProdList
1427
Advantage
58
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View Lastest Price from 4-Hydroxythiobenzamide manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
4-HYDROXYTHIOBENZAMIDE 25984-63-8
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 ton
Release date
2024-12-16
Shandong Huizhihan Supply Chain Co., Ltd
Product
4-Hydroxythiobenzamide 25984-63-8
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20Tons
Release date
2024-12-11
WUHAN FORTUNA CHEMICAL CO., LTD
Product
4-Hydroxythiobenzamide 25984-63-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%min
Supply Ability
1000kg
Release date
2022-07-21

25984-63-8, 4-HydroxythiobenzamideRelated Search:

ethyl 2-(4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate Febuxostat 4-HYDROXYTHIOBENZAMIDE 4-METHOXYTHIOBENZAMIDE 2,3-DIHYDRO-1,4-BENZODIOXINE-6-CARBOTHIOAMIDE 6,7-DIMETHOXY-1,2,3,4-TETRAHYDROISOQUINOLINE-1-THIONE Tritiozine Vanitiolide 4-Ethoxybenzenecarbothioamide Benzamide THIOBENZAMIDE 4-[5-(TRIFLUOROMETHYL)PYRID-2-YLOXY]THIOBENZAMIDE 4-METHOXY-3-NITROBENZENE-1-CARBOTHIOAMIDE 2,3-DIHYDROBENZO[B]FURAN-5-CARBOTHIOAMIDE 1,3-BENZODIOXOLE-5-CARBOTHIOAMIDE 1-BENZYL-3-(TERT-BUTYL)-1H-PYRAZOLE-5-CARBOXYLIC ACID

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