ChemicalBook > CAS DataBase List > Cephalomannine

Cephalomannine

Product Name: Cephalomannine
CAS No.: 71610-00-9
Chemical Name: Cephalomannine
Synonyms: TAXOL B;NSC 318735;CEPHALOMANNINE;CEPHALOMANNINE(P);Cephalomannine CAS;Cephalomannine, >99%;paclitaxel iMpurity I;Paclitaxel Impurity B;Paclitaxel harringine;Paclitaxel EP Impurity B
CBNumber: CB0214160
Molecular Formula: C45H53NO14
Formula Weight: 831.9
MOL File: 71610-00-9.mol

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Cephalomannine Property

Melting point:: 139-141?C
Boiling point:: 929.5±65.0 °C(Predicted)
Density: 1.36±0.1 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: DMSO: 14 mg/mL, soluble
form: solid
pka: 11.95±0.20(Predicted)
color: White to Pale Beige
InChIKey: DBXFAPJCZABTDR-WBYYIXQISA-N
CAS DataBase Reference: 71610-00-9

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Safety

Hazard Codes: Xi
Risk Statements: 37/38-41
Safety Statements: 26-39
WGK Germany: 3
HS Code: 29329990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR2111
Product name: Paclitaxel Related Compound A
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 50mg
Price: $792
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1491343
Product name: Paclitaxel Related Compound A
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 20mg
Price: $1940
Updated: 2025/07/31

Cayman Chemical

Product number: 27878
Product name: Cephalomannine
Packaging: 1mg
Price: $48
Updated: 2024/03/01

Cayman Chemical

Product number: 27878
Product name: Cephalomannine
Packaging: 10mg
Price: $324
Updated: 2024/03/01

Sigma-Aldrich

Product number: C4991
Product name: Cephalomannine
Purity: ≥97% (HPLC), solid
Packaging: 1mg
Price: $214
Updated: 2025/07/31

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Cephalomannine Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Occurrence

A taxane derivative, cephalomannine occurs in the extract of Cephalotaxus rnannii. It has been obtained as colourless needles from MeOH aq. and is laevorotatory with a specific rotation of [α]D -41° (MeOH).

Uses

Cephalomannine is an active anti-cancer agent obtained from Taxus yunnanensis and has an antineoplastic effect on tumors found in mice. Cephalomannine is a chemotherapy drug that is given as a treatment for some types of cancer. Cephalomannine is most com

Uses

Antitumor, antiproliferative.

Uses

similar anti-cancer function as Taxol

in vivo

Cephalomannine (0.4 mg/kg, intraperitoneal injection, 10 days) could significantly inhibit the growth of lung cancer cells in nude mice xenograft model, with no obvious side effects^[3].
Cephalomannine can interrupt the interaction between APEX1 and HIF-1α by competitive binding with APEX1^[3].

Animal Model:	BALB/C nude mice xenograft model^[3]
Dosage:	0.4 mg/kg
Administration:	Intraperitoneal injection (i.p.)
Result:	Reduced the volume and weight of H460 xenograft tumors.

Animal Model:	BALB/c nude mice bone metastasis xenograft model^[4]
Dosage:	10 mg/kg, 20 mg/kg
Administration:	Intraperitoneal injection (i.p.)
Result:	Decreased bone destruction, reduced bioluminescence intensity and number of bone metastases, significantly extended time to endpoint events, decreased UBE2S expression and number of osteoclasts, and did not produce significant toxicity to the heart, liver, or kidney of nude mice.

IC 50

HIF-1α

Cephalomannine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Cephalomannine manufacturers

Changsha Staherb Natural Ingredients Co., Ltd.

Product: Cephalomannine 71610-00-9
Price: US $0.00-0.00/mg
Min. Order: 20mg
Purity: 98% HPLC
Supply Ability: 100kg
Release date: 2022-10-21

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Paclitaxel Cephalomannine 71610-00-9
Price: US $0.00/mg
Min. Order: 10mg
Purity: 0.98
Supply Ability: 10g
Release date: 2024-04-03

Shanghai Standard Technology Co., Ltd.

Product: Cephalomannine 71610-00-9
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2019-12-26

71610-00-9, CephalomannineRelated Search:

Homoharringtonine Baccatine III CEPHALOTAXINE (2R,3S)-3-PHENYLISOSERINE ETHYLESTER 7-EPI-CEPHALOMANNINE 7-Epitaxol Paclitaxel IMpurity F N-Debenzoyl-N-[(3E)-hex-3-enoyl]paclitaxel Paclitaxel EP Impurity I ACETYLTAXOL, 7-(P) 7-EPI-10-DEACETYLTAXOL Deacetyltaxol Iso CephaloMannine Paclitaxel EP Impurity J Paclitaxel impurity 19/Taxol E/(αR,βS)-α-Hydroxy-β-[[(2S)-2-methyl-1-oxobutyl]amino]benzenepropanoic Acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-Bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetr PACLITAXEL C Paclitaxel IMpurity O (4S,5R)-3-Benzoyl-2-(4-methoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid

TAXOL B

BENZENEPROPANOICACID,ALPHA-HYDROXY-BETA-[(2-METHYL-1-OXO-2-BUTENYL)AMINO]-,6,12B-BIS(ACETYLOXY)-12-(BENZOYLOXY)-2A,3,4,4A,5,6,9,10,11,12,12A,12B-DODECAHYDRO-4,11-DIHYDROXY-4A,8,13,13-TETRAMETHYL-5-OXO-7,11-METHANO-1H-CYCLODECA[3,4]BENZ[1,2-

BENZENEPROPANOIC ACID, ALPHA-HYDROXY-BETA-[(2-METHYL-1-OXO-2-BUTENYL)AMINO]-,6,12B-BIS(ACETYLOXY)-12-(BENZOYLOXY)-2A,3,4,4A,5,6,9,10,11,12,12A,12B-DODECAHYDRO-4,11-DIHYDROXY-4A,8,13,13-TETRAMETHYL-5-OXO-7,11-METHANO-1H-CYCLODECA[3,4]BENZ[1,2-B]OXET-9-YL ESTER,[2AR-[2A,4,4A,6,9[R*,S*(E)],11,12,12A,12B]]-

CEPHALOMANNINE

paclitaxel iMpurity I

CephaloMannine, froM Taxus chinensis

(αR,βS)-α-Hydroxy-β-[[(2E)-2-Methyl-1-oxo-2-buten-1-yl]aMino]benzenepropanoic Acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)- 12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetraMethyl-5-oxo-7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl Ester

NSC 318735

Paclitaxel EP Impurity B

N-Debenzoyl-N-tigloylpaclitaxel

Cephalomannine, 98%, from Taxus chinensis (Pilg.) Rehder

N-debenzoyl-N-tigloylpaclitaxel (cephalomannine)

Paclitaxel Related Compound A (Cephalomannine)

Paclitaxel Impurity 2（Paclitaxel EP Impurity B）

Cephalomannine 71610-00-9

Paclitaxel Impurity Ⅰ:Cephalomannine

Paclitaxel EP Impurity B N-debenzoyl-N-tigloylpaclitaxel (cephalomannine)

Cephalomannine, >99%

Benzenepropanoic acid, α-hydroxy-β-[[(2E)-2-methyl-1-oxo-2-buten-1-yl]amino]-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-

Paclitaxel Related Compound A (20 mg) (Ce-phalomannine)

Paclitaxel Related CoMpound A

CEPHALOMANNINE (TAXOL B)

CEPHALOMANNINE:BENZENEPROPANOICACID, -HYDROXY--[(2-METHYL-1-OXO-2-BUTENYL)AMINO]-,6,12B-BIS(ACETYLOXY)-12-(BENZOYLOXY)-2A,3,4,4A,5,6,9,10,11,12,12A,12B-DODECAHYDRO-4,11-DIHYDROXY-4A,8,13,13-TETRAMETHYL-5-OXO-7,11-METHANO-1H-CYCLODECA[3,4]BENZ[1,2-B]OX...

-[(2-methyl-1-oxo-2-butenyl)amino]-,6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-ylester,[2aR-[2aα,4β,4aβ,6β,9α[αR*,βS*(E)],11α,12α,12aα,12bα]]-

Benzenepropanoicacid, α-hydroxy-β

CEPHALOMANNINE(P)

N-Debenzoyl-N-tigloylpaclitaxel (Ce

3′-N-(trans-2-methyl-2-butenoyl)-3′-N-debenzoylpaclitaxel

Cephalomannine USP/EP/BP

Taxus Extract Cephalomannine

CephalomannineQ: What is Cephalomannine Q: What is the CAS Number of Cephalomannine Q: What is the storage condition of Cephalomannine Q: What are the applications of Cephalomannine

Paclitaxel Related Compound A (Cephalomannine) (1491343)

(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12-(Benzoyloxy)-4,11-dihydroxy-9-(((2R,3S)-2-hydroxy-3-((E)-2-methylbut-2-enamido)-3-phenylpropanoyl)oxy)-4a,8,13,13-tetramethyl-5-oxo-3,4,4a,5,6,9,10,11,12,12a-decahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxete-6,12b(2aH)-diyl diacetate

Paclitaxel Cephalomannine

Paclitaxel USP Related Compound A

Paclitaxel Impurity B

4,10β-bis(acetyloxy)-1,7β-dihydroxy-13α-[[(2R,3S)-2-hydroxy-3-[[(2E)-2-methylbut-2-enoyl]amino]-3-phenylpropanoyl]oxy]-9-oxo-5β,20-epoxytax-11-en-2α-ylbenzoate(N-debenzoyl-N-tigloylpaclitaxel

4-(acetyloxy)-10β,13α-bis[[(2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl]oxy]-1,7β-dihydroxy-9-oxo-5β,20-epoxytax-11-en-2α-ylbenzoate(10-O-[(2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl]-10-O-deacetylpaclitaxel)

Sanjian Shanning alkaloid

Cephalomannine CAS

Paclitaxel EP Impurity B/Cephalomannine

Paclitaxel harringine

Cephalomannine, 10 mM in DMSO

Paclitaxel Impurity Ⅰ:Cephalomannine

Paclitaxel Imp. B (EP): N-debenzoyl-N-tigloylpaclitaxel (cephalomannine)

71610-00-9

610-00-9

C45H53NO14

8319

BioChemical

Antibiotics

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Alkaloids