ChemicalBook > CAS DataBase List > Indole-4-carboxaldehyde
Indole-4-carboxaldehyde
- Product Name
- Indole-4-carboxaldehyde
- CAS No.
- 1074-86-8
- Chemical Name
- Indole-4-carboxaldehyde
- Synonyms
- 4-INDOLECARBALDEHYDE;1H-INDOLE-4-CARBALDEHYDE;4-FLUOROINDOLE;1H-INDOLE-4-CARBOXALDEHYDE;NSC 337264;e-4-carboxaL;4-FORMYLINDOLE;INDOLE-4-ALDEHYDE;4-Formyl-1H-indole;RARECHEM AH BS 0110
- CBNumber
- CB0217303
- Molecular Formula
- C9H7NO
- Formula Weight
- 145.16
- MOL File
- 1074-86-8.mol
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Indole-4-carboxaldehyde Property
- Melting point:
- 139-143 °C(lit.)
- Boiling point:
- 339.1±15.0 °C(Predicted)
- Density
- 1.278±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- DMF: 10 mg/ml; DMSO: 3 mg/ml; Ethanol: 10 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
- pka
- 15.84±0.30(Predicted)
- form
- powder to crystal
- color
- Light yellow to Brown
- Water Solubility
- Soluble in ethanol and acetone. Insoluble in water.
- Sensitive
- Air Sensitive
- InChI
- InChI=1S/C9H7NO/c11-6-7-2-1-3-9-8(7)4-5-10-9/h1-6,10H
- InChIKey
- JFDDFGLNZWNJTK-UHFFFAOYSA-N
- SMILES
- N1C2=C(C(C=O)=CC=C2)C=C1
- CAS DataBase Reference
- 1074-86-8(CAS DataBase Reference)
- NIST Chemistry Reference
- 1H-indole-4-carboxaldehyde(1074-86-8)
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H317May cause an allergic skin reaction
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 632422
- Product name
- Indole-4-carboxaldehyde
- Purity
- 97%
- Packaging
- 1g
- Price
- $129
- Updated
- 2023/06/20
Sigma-Aldrich
- Product number
- 632422
- Product name
- Indole-4-carboxaldehyde
- Purity
- 97%
- Packaging
- 5g
- Price
- $628
- Updated
- 2023/06/20
TCI Chemical
- Product number
- I0712
- Product name
- Indole-4-carboxaldehyde
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $160
- Updated
- 2024/03/01
TCI Chemical
- Product number
- I0712
- Product name
- Indole-4-carboxaldehyde
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $400
- Updated
- 2024/03/01
Alfa Aesar
- Product number
- H28019
- Product name
- Indole-4-carboxaldehyde, 97%
- Packaging
- 5g
- Price
- $713
- Updated
- 2021/12/16
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Indole-4-carboxaldehyde Chemical Properties,Usage,Production
Chemical Properties
White to dark brown solid
Uses
4-Indolecarbaldehyde is a synthetic intermediate used for pharmaceutical synthesis. Also used as reactant in Biginelli reaction, synthesis of aurora kinase A inhibitors, preparation of antitumor agents, intermolecular Friedel-Crafts acylation, preparation of inhibitors of cell division in E. coli and synthesis of Hantzsch pyridine-containing Schiff bases.
Uses
Indole-4-carboxaldehyde is usually used as reactant in Biginelli reaction,preparation of antitumor agents,intramolecular Friedel-Crafts acylation,preparation of inhibitors of cell division in E. Coli,synthesis of Hantzsch pyridine-containing Schiff bases.
Definition
ChEBI: Indole-4-carbaldehyde is a heteroarenecarbaldehyde that is indole in which the hydrogen at position 4 has been replaced by a formyl group. It has a role as an algal metabolite. It is a member of indoles and a heteroarenecarbaldehyde.
Synthesis Reference(s)
The Journal of Organic Chemistry, 46, p. 1752, 1981 DOI: 10.1021/jo00321a053
Tetrahedron, 39, p. 3695, 1983 DOI: 10.1016/S0040-4020(01)88608-7
General Description
Indole-4-carboxaldehyde participates in the synthesis of arcyriacyanin A. Synthesis of 4-indole-4-carboxaldehyde has been reported. Intramolecular Friedel-Crafts (FC) acylation of indole-4-carboxaldehyde has been reported.
Synthesis
Tetrapropylammonium perruthenate (0.3 g, 0.85 mmol) was added in portions to a mixture of alcohol product from 1H-Indole-4-Methanol (2.5 g, 17 mmol), N-methylmorpholine N-oxide (3.0 g, 25 mmol) and 4 A molecular sieves (3.0 g) in anhydrous methylene chloride (30 mL) at room temperature. The mixture was stirred at room temperature under nitrogen for 1 h and then filtered. The filtrate was concentrated in vacuo, and the residue was purified by chromatography (SiO2, CH2Cl2) to provide Indole-4-carboxaldehyde as a white powder (2.0 g, 80percent): 1H NMR (300 MHz, CDCl3) δ10.2 (s, 1H), 8.52 (br s, 1H), 7.64-7.69 (m, 2H), 7.31-7.44 (m, 3H), CI MS m/z=146 [C9H7NO+H]+.
Indole-4-carboxaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Indole-4-carboxaldehyde manufacturers
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- Indole-4-carboxaldehyde 1074-86-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- Indole-4-carboxaldehyde 1074-86-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
Career Henan Chemical Co
- Product
- Indole-4-carboxaldehyde 1074-86-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000KGS
- Release date
- 2019-12-30
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