4-Amino-5,6,7,8-tetrahydro-5-oxo-8-(β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-6-carboxamide

Product Name: 4-Amino-5,6,7,8-tetrahydro-5-oxo-8-(β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-6-carboxamide
CAS No.: 36707-00-3
Chemical Name: 4-Amino-5,6,7,8-tetrahydro-5-oxo-8-(β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-6-carboxamide
Synonyms: API-1;NSC 177223;API-1(NSC 177223);API-1, 10 mM in DMSO;4-Amino-5-oxo-8-pentofuranosyl-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide;4-Amino-5,8-dihydro-5-oxo-8-β-D-ribofuranosyl-pyrido[2,3-d]pyrimidine-6-carboxamide;Pyrido[2,3-d]pyrimidine-6-carboxamide, 4-amino-5,8-dihydro-5-oxo-8-β-D-ribofuranosyl-;4-Amino-5,6,7,8-tetrahydro-5-oxo-8-(β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-6-carboxamide;TRAIL,API 1,PKB,Akt,Inhibitor,API-1,inhibit,Akt/PKB inhibitor,Protein kinase B,API1,Apoptosis;4-amino-8-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-oxopyrido[2,3-d]pyrimidine-6-carboxamide
CBNumber: CB02264862
Molecular Formula: C13H15N5O6
Formula Weight: 337.29
MOL File: 36707-00-3.mol

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4-Amino-5,6,7,8-tetrahydro-5-oxo-8-(β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-6-carboxamide Property

storage temp.: Store at RT
solubility: DMF: slightly soluble; DMSO: 2 mg/ml
form: powder
color: white to beige

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Safety

RIDADR: UN 2811 6.1 / PGIII

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1342
Product name: API-1
Packaging: 5mg
Price: $139
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1342
Product name: API-1
Packaging: 25mg
Price: $552
Updated: 2022/05/15

Cayman Chemical

Product number: 22081
Product name: API-1
Purity: ≥98%
Packaging: 1mg
Price: $34
Updated: 2024/03/01

Cayman Chemical

Product number: 22081
Product name: API-1
Purity: ≥98%
Packaging: 5mg
Price: $152
Updated: 2024/03/01

Cayman Chemical

Product number: 22081
Product name: API-1
Purity: ≥98%
Packaging: 10mg
Price: $270
Updated: 2024/03/01

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4-Amino-5,6,7,8-tetrahydro-5-oxo-8-(β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-6-carboxamide Chemical Properties,Usage,Production

Uses

NSC 177223 is a Akt/protein kinase B inhibitor. It binds to pleckstrin homologous domain of Akt and blocks Akt membrane translocation. Treatment of cancer cells with NSC 177223 results in inhibition of the kinase activities and induction of cell growth arrest and apoptosis selectively in human cancer cells that harbor constitutively activated Akt.

Biological Activity

API-1 is a potent and specific Akt/PKB inhibitor. API-1 binds to pleckstrin homology (PH) domain of Akt and blocks Akt membrane translocation. The compound inhibits all three members of the family Akt1/PKBa, Akt2/PKBb and Akt3/PKBg. API-1 does not inhibit the activation of PKC, SGK, PKA, STAT3, Erk-1/2 or JNK.

in vivo

API-1 (10 mg/kg; i.p.; daily for 6-8 weeks) selectively inhibits the growth of tumors with hyperactivated Akt in OVCAR3 and PANC-1 xenograft mice model^[3].

Animal Model:	8-week-old female nude mice (implanted tumors with hyperactivated Akt (OVCAR3 and PANC-1) into the left flank and those tumors that express low levels of activated Akt (OVCAR5 and COLO357) into the right flank)^[3]
Dosage:	10 mg/kg
Administration:	Intraperitoneal injection (i.p.); daily for 6-8 weeks
Result:	Inhibited OVCAR3 and PANC1 tumor growth by 70 and 50%, respectively. Had little effect on the growth of OVCAR5 and COLO357 cells in nude mice. Had no effects on blood glucose level, body weight, activity, and food intake of mice. Phosphorylation levels of Akt were reduced about 70% without a change of total Akt content.

IC 50

Caspase-8; Caspase 3; Caspase-9; PARP

storage

Store at RT

4-Amino-5,6,7,8-tetrahydro-5-oxo-8-(β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-6-carboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Amino-5,6,7,8-tetrahydro-5-oxo-8-(β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-6-carboxamide Suppliers

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36707-00-3, 4-Amino-5,6,7,8-tetrahydro-5-oxo-8-(β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-6-carboxamideRelated Search:

NSC 177223

4-amino-8-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-oxopyrido[2,3-d]pyrimidine-6-carboxamide

4-Amino-5,6,7,8-tetrahydro-5-oxo-8-(β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-6-carboxamide

4-Amino-5,8-dihydro-5-oxo-8-β-D-ribofuranosyl-pyrido[2,3-d]pyrimidine-6-carboxamide

API-1

4-Amino-5-oxo-8-pentofuranosyl-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide

Pyrido[2,3-d]pyrimidine-6-carboxamide, 4-amino-5,8-dihydro-5-oxo-8-β-D-ribofuranosyl-

API-1(NSC 177223)

TRAIL,API 1,PKB,Akt,Inhibitor,API-1,inhibit,Akt/PKB inhibitor,Protein kinase B,API1,Apoptosis

API-1, 10 mM in DMSO

36707-00-3

C13H15N5O6