ChemicalBook > CAS DataBase List > Rutaecarpine

Rutaecarpine

Product Name: Rutaecarpine
CAS No.: 84-26-4
Chemical Name: Rutaecarpine
Synonyms: RUTECARPINE;Rutacarpine;RHETINE;Rutaecarpine;Rutaccarpine;Rutaecarpine;RUTECARPINE 95+;Rutaecarpine-RM;Rutaecarpine >Rutaecarpine std.
CBNumber: CB0226965
Molecular Formula: C18H13N3O
Formula Weight: 287.32
MOL File: 84-26-4.mol

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Rutaecarpine Property

Melting point:: 259.5-260°
Boiling point:: 429.62°C (rough estimate)
Density: 1.2030 (rough estimate)
refractive index: 1.5855 (estimate)
storage temp.: Sealed in dry,2-8°C
solubility: DMSO: 18 mg/mL clear yellow solution, soluble
form: solid
pka: 15.79±0.20(Predicted)
color: white
Merck: 14,8298
InChI: InChI=1S/C18H13N3O/c22-18-13-6-2-4-8-15(13)20-17-16-12(9-10-21(17)18)11-5-1-3-7-14(11)19-16/h1-8,19H,9-10H2
InChIKey: ACVGWSKVRYFWRP-UHFFFAOYSA-N
SMILES: N1C2=C(C=CC=C2)C(=O)N2CCC3C4=C(NC=3C=12)C=CC=C4
CAS DataBase Reference: 84-26-4(CAS DataBase Reference)

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Safety

Hazard Codes: T
Risk Statements: 25-36/37/38
Safety Statements: 45-36-26
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: NM3454000
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: R3277
Product name: Rutaecarpine
Purity: >98% (HPLC)
Packaging: 5mg
Price: $86
Updated: 2025/07/31

Sigma-Aldrich

Product number: R3277
Product name: Rutaecarpine
Purity: >98% (HPLC)
Packaging: 25mg
Price: $673
Updated: 2025/07/31

Sigma-Aldrich

Product number: PHL89319
Product name: Rutaecarpine
Purity: phyproof<SUP>®</SUP> Reference Substance
Packaging: 10 mg
Price: $229
Updated: 2025/07/31

TCI Chemical

Product number: R0102
Product name: Rutaecarpine
Purity: >98.0%(HPLC)(N)
Packaging: 200mg
Price: $198
Updated: 2025/07/31

Cayman Chemical

Product number: 22897
Product name: Rutaecarpine
Purity: ≥98%
Packaging: 5mg
Price: $49
Updated: 2024/03/01

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Rutaecarpine Chemical Properties,Usage,Production

Description

This alkaloid occurs with Evodiamine (q.v.) in the Chinese drug 'Wou-chou-yu' which is the dried fruit of Evodia rutaecarpa Benth. It crystallizes from boiling EtOH as colourless, or pale yellow, needles and is optically inactive. The acetyl derivative has m.p. 184-6°C and the benzoyl compound, m.p. 194°C. The alkaloid gives a yellow colour with concentrated H2S04 and is decomposed by KOH in boiling amyl alcohol yielding anthranilic acid and 3-{3-aminoethylindole- 2-O!carboxylic acid, CllH120 2N2, silky crystals, m.p. 257°C.
Pharmacologically, the alkaloid causes increased arterial pressure on injection.

Chemical Properties

Solid

Uses

Rutaecarpine is an indole alkaloid contained in the fruit of Evodiae fruits. It been shown to ameliorate bodyweight gain through orexigenic neuropeptides NPY and AgRP. It also playes a role in the treatment of high blood pressure

Definition

ChEBI: Rutecarpine is a member of beta-carbolines.

in vivo

Rutaecarpine showed in vivo anti-inflammatory activity on rat l-carrageenan induced paw edema by intraperitoneal administration^[1]. Rutaecarpine significantly decreases the number of antibody-forming cells and causes weight decrease in spleen in a dose-dependent manner. In addition, rutaecarpine administered mice exhibit reduced splenic cellularity, decreased numbers of total T cells, CD4+ cells, CD8+ cells, and B cells in spleen. IL-2, interferon and IL-10 mRNA expressions are suppressed significantly by rutaecarpine treatment. The number of CD4+IL-2+ cells is reduced significantly following administration of mice with rutaecarpine^[3].

IC 50

COX-2: 0.28 μM (IC₅₀, in BMMC); COX-1: 8.7 μM (IC₅₀, in BMMC)

References

Asahina, Kashiwagi., J. Pharm. Chim., 14,54 (1916)
Asahina, Mayeda.,J. Pharm. Soc., Japan, No. 416 (1916)
Asahina, Fujita., ibid, 863 (1921)
Kermack, Perkin, Robinson.,J. Chem. Soc., 119,1615 (1921)
Asahina, Manske, Robinson., ibid, 1708 (1927)
Asahina, Irie, Ohta., J. Pharm. Soc., Japan, 48, 51 (1928)
Ohta., ibid, 60, 109 (1940)
Schopf, Steuer., Annalen, 558, 124 (1947)
Biosynthesis:
Yamazaki, Ikuta., Tetrahedron Lett., 3221 (1966)
Yamazakietal., ibid, 3317 (1967)
Pharmacology:
Raymond-Hamet., Cornpt. rend., 220, 749 (1945)

Rutaecarpine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Rutaecarpine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Rutaecarpine 84-26-4
Price: US $0.00-0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%min HPLC
Supply Ability: 100kg
Release date: 2021-09-15

Henan Aochuang Chemical Co.,Ltd.

Product: Rutaecarpine 84-26-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-29

Dingwang Technology (Wuhan) Co., Ltd.

Product: Rutaecarpine 84-26-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 tons
Release date: 2022-11-02

84-26-4, RutaecarpineRelated Search:

Hydroxyevodiamine Evodiamine CASTICIN Rutaevin 7-acetate EUDESMINE evocarpine Fructus Evodiae Polysaccharide Schisandrin WUWEIZISU C Crocin 1-[(2E,4E,6E,8E,10E,12E,14E)-b-D-glucopyranosyl 2,6,11,15-tetramethyl-2,4,6,8,10,12,14-hexadecaheptaenedioate] 6-O-b-D-glucopyranosyl-b-D-Glucopyranose 2α,19α－Dihydroxyursolic acid 6-(2-O-alpha-L-Arabinopyranosyl-beta-D-glucopyranosyl)-2-[4-(beta-D-glucopyranosyloxy)phenyl]-5,7-dihydroxy-4H-1-benzopyran-4-one schisanhenol KU-55933 (ATM Kinase Inhibitor) Rutin Gefitinib Stigmasterol

:3,4]pyrido[2,1-b]quinazolin-5(7H)-one

Indolo(2',3':3,4)pyrido(2,1-b)quinazolin-5(7H)-one, 8,13-dihydro- (9CI)

Rutacarpine

Rutecarpine (8CI)

7,8-dihydroindolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(13H)-one

RHETINE

RUTECARPINE

8,13-DIHYDRO-INDOLO[2'3':3,4]PYRIDO[2,1-B]QUINAZOLIN-5(7H)-ONE

RUTECARPINE 95+

Rutaecarpine std.

Indolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one,8,13-dihydro-

Rutecarpine, 8,13-Dihydroindolo[2μ,3μ:3,4]pyrido[2,1-b]quinazolin-5(7H)-one

5,7,8,13-Tetrahydroindolo[2',3':3,4]pyrido[2,1-b]quinazoline-5-one

Rutaecarpine (Rutecarpine)

Rutaecarpine

Rutaecarpine (synthetic)

Rutaecarpine, froM TetradiuM ruticarpuM

Rutaecarpine, 98%, from Evodia rutaecarpa (Juss.) Benth.

Rutaecarpine 84-26-4

Rutaecarpine &gt

Rutaecarpine USP/EP/BP

Rutaccarpine

Rutaecarpine 98%min

Rutaecarpine-RM

Rutaecarpine, Indoloquinazoline alkaloid

Wu Zhuyu alkaloid

Rutaecarpine, 10 mM in DMSO

Rutaecarpine

84-26-4

84-16-4

Cell Signaling and Neuroscience

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pharmaceutical intermediate

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reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

Indoles and derivatives

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