7-IODO-4-CHLOROQUINOLINE
- Product Name
- 7-IODO-4-CHLOROQUINOLINE
- CAS No.
- 22200-50-6
- Chemical Name
- 7-IODO-4-CHLOROQUINOLINE
- Synonyms
- BUTTPARK 89\09-06;7-IODO-4-CHLOROQUINOLINE;Quinoline, 4-chloro-7-iodo-
- CBNumber
- CB0227816
- Molecular Formula
- C9H5ClIN
- Formula Weight
- 289.5
- MOL File
- 22200-50-6.mol
7-IODO-4-CHLOROQUINOLINE Property
- Melting point:
- 101-102 °C
- Boiling point:
- 174-175 °C(Press: 4 Torr)
- Density
- 1.919±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 2.05±0.27(Predicted)
- Appearance
- Colorless to light yellow Liquid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- 126417
- Product name
- 7-Iodo-4-chloroquinoline
- Purity
- >95%
- Packaging
- 1g
- Price
- $450
- Updated
- 2021/12/16
- Product number
- 126417
- Product name
- 7-Iodo-4-chloroquinoline
- Purity
- >95%
- Packaging
- 5g
- Price
- $1350
- Updated
- 2021/12/16
- Product number
- 61-3076
- Product name
- 7-Iodo-4-chloroquinoline
- Purity
- 95%-98%
- Packaging
- 5g
- Price
- $475
- Updated
- 2021/12/16
- Product number
- CM143574
- Product name
- 7-Iodo-4-chloroquinoline
- Purity
- 97%
- Packaging
- 10g
- Price
- $644
- Updated
- 2021/12/16
- Product number
- 22200506
- Product name
- 7-Iodo-4-chloroquinoline
- Packaging
- 10g
- Price
- $675.22
- Updated
- 2021/12/16
7-IODO-4-CHLOROQUINOLINE Chemical Properties,Usage,Production
Synthesis
22297-71-8
22200-50-6
General procedure for the synthesis of 4-chloro-7-iodoquinoline from 4-hydroxy-7-iodoquinoline: 4-hydroxy-7-iodoquinoline (4.5 g) was dissolved in 30 mL of phosphorus oxychloride (POCl3). The reaction mixture was heated to reflux for 2 hours. Upon completion of the reaction, the excess phosphorous trichloride was removed by distillation under reduced pressure. The residue was alkalized with ammonium hydroxide (NH4OH) to pH>7 and subsequently extracted with ethyl acetate (EtOAc). The organic layers were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 3.95 g (80% yield) of 4-chloro-7-iodoquinoline as a yellow solid.
References
[1] Patent: US2008/234267, 2008, A1. Location in patent: Page/Page column 13
[2] Patent: WO2005/63739, 2005, A1. Location in patent: Page/Page column 53
[3] Chemistry of Heterocyclic Compounds (New York, NY, United States), 1980, vol. 16, # 7, p. 754 - 757
[4] Khimiya Geterotsiklicheskikh Soedinenii, 1980, # 7, p. 972 - 975
[5] Journal of the American Chemical Society, 1949, vol. 71, p. 3236
7-IODO-4-CHLOROQUINOLINE Preparation Products And Raw materials
Raw materials
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