4-Chloro-3-nitroquinoline
- Product Name
- 4-Chloro-3-nitroquinoline
- CAS No.
- 39061-97-7
- Chemical Name
- 4-Chloro-3-nitroquinoline
- Synonyms
- 3-Nitro-4-chloroquinoline;4-CHLORO-3-NITROQUINOLINE;4-Chloro-3-nitroqulinoline;QUINOLINE, 4-CHLORO-3-NITRO-;4-Chloro-3-nitroquinoline ,98%;4-Chloro-3-nitroquinoline ISO 9001：2015 REACH
- CBNumber
- CB6760548
- Molecular Formula
- C9H5ClN2O2
- Formula Weight
- 208.6
- MOL File
- 39061-97-7.mol
4-Chloro-3-nitroquinoline Property
- Melting point:
- 121-122°C
- Boiling point:
- 333.8±22.0 °C(Predicted)
- Density
- 1.484±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- -0.28±0.24(Predicted)
- color
- Pale Yellow
- InChI
- InChI=1S/C9H5ClN2O2/c10-9-6-3-1-2-4-7(6)11-5-8(9)12(13)14/h1-5H
- InChIKey
- ZRFUZDDJSQVQBY-UHFFFAOYSA-N
- SMILES
- N1C2C(=CC=CC=2)C(Cl)=C([N+]([O-])=O)C=1
- CAS DataBase Reference
- 39061-97-7(CAS DataBase Reference)
Safety
- Safety Statements
- 24/25
- HS Code
- 29334900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C374825
- Product name
- 4-Chloro-3-nitroquinoline
- Packaging
- 25g
- Price
- $590
- Updated
- 2021/12/16
- Product number
- FC20069
- Product name
- 4-Chloro-3-nitroquinoline
- Packaging
- 50g
- Price
- $600
- Updated
- 2021/12/16
- Product number
- 072162
- Product name
- 4-Chloro-3-nitroquinoline
- Purity
- 95+%
- Packaging
- 25g
- Price
- $628
- Updated
- 2021/12/16
- Product number
- HCH0023468
- Product name
- 4-CHLORO-3-NITROQUINOLINE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $704.55
- Updated
- 2021/12/16
- Product number
- JK221037
- Product name
- 4-Chloro-3-nitroquinoline
- Purity
- 98%
- Packaging
- 1g
- Price
- $199
- Updated
- 2021/12/16
4-Chloro-3-nitroquinoline Chemical Properties,Usage,Production
Chemical Properties
yellow crystal powder
Uses
4-Chloro-3-nitroquinoline (cas# 39061-97-7) is a compound useful in organic synthesis.
Synthesis
50332-66-6
39061-97-7
General procedure for the synthesis of 4-chloro-3-nitroquinoline from 4-hydroxy-3-nitroquinoline: The intermediate 3-nitro-4-hydroxyquinoline (18.7 g, 98.4 mmol) was suspended in dichloromethane (150 mL). Thionyl chloride (17.2 mL, 236 mmol) and N,N-dimethylformamide (DMF, 9.2 mL, 118 mmol) were added sequentially to the suspension. The reaction mixture was heated to reflux and kept reacting overnight. Upon completion of the reaction, the mixture was slowly poured into ice water. The organic and aqueous layers were separated and the organic layer was washed sequentially with saturated sodium bicarbonate solution, water and saturated brine. The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The resulting residue (20.52 g, 93% yield) can be used directly in the subsequent reaction without further purification.
References
[1] Patent: EP2674170, 2013, A1. Location in patent: Paragraph 0228
[2] Patent: US2014/141033, 2014, A1. Location in patent: Page/Page column
[3] Journal of Medicinal Chemistry, 1991, vol. 34, # 3, p. 1202 - 1206
[4] Journal of Medicinal Chemistry, 2006, vol. 49, # 11, p. 3354 - 3361
[5] Patent: WO2007/89507, 2007, A1. Location in patent: Page/Page column 20-21
4-Chloro-3-nitroquinoline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Chloro-3-nitroquinoline manufacturers
- Product
- 4-Chloro-3-nitroquinoline 39061-97-7
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2021-10-14
- Product
- 4-Chloro-3-nitroquinoline 39061-97-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-26