ChemicalBook > CAS DataBase List > D-CAMPHOR

D-CAMPHOR

Product Name
D-CAMPHOR
CAS No.
464-49-3
Chemical Name
D-CAMPHOR
Synonyms
Bicyclo[2.2.1]heptan-2-one, 1,7,7-trimethyl-, (1R)-;(1R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-one;d-camphre;FEMA 2230;d-2-Bornanone;7,7-trimethyl-(1r)-bicyclo(2.2.1)heptan-2-on;(1R)-1,7,7-TRIMETHYLBICYCLO[2.2.1]HEPTAN-2-ONE;D-CAMPHOR;camphorusp;Camphor usp
CBNumber
CB0233316
Molecular Formula
C10H16O
Formula Weight
152.23
MOL File
464-49-3.mol
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D-CAMPHOR Property

Melting point:
178-182 °C (lit.)
Boiling point:
204 °C
alpha 
D25 +41 to +43° (c = 10 in U.S.P. alcohol) according to U.S.P. specif
Density 
0,99 g/cm3
vapor density 
5.24 (vs air)
vapor pressure 
4 mm Hg ( 70 °C)
FEMA 
2230 | D-CAMPHOR
refractive index 
44.5 ° (C=20, EtOH)
Flash point:
148 °F
storage temp. 
2-8°C
solubility 
Slightly soluble in water, very soluble in alcohol and in light petroleum, freely soluble in fatty oils, very slightly soluble in glycerol.
form 
Crystals
color 
White
Odor
at 10.00 % in dipropylene glycol. camphor minty phenolic herbal woody
Odor Type
camphoreous
biological source
synthetic
explosive limit
3.5%
optical activity
[α]25/D +44°, c = 10 in ethanol
Water Solubility 
Soluble in water (0.1 g/L at 20°C).
Merck 
14,1732
JECFA Number
1395
BRN 
2042745
Stability:
Stable. Incompatible with strong reducing agents, strong oxidizing agents, chlorinated solvents. Protect from direct sunlight.
LogP
2.3 at 20℃
CAS DataBase Reference
464-49-3(CAS DataBase Reference)
EPA Substance Registry System
D-Camphor (464-49-3)
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Safety

Hazard Codes 
F,Xn,Xi
Risk Statements 
11-22-36/37/38-20/21/22-36
Safety Statements 
16-26-36-37/39
RIDADR 
UN 2717 4.1/PG 3
WGK Germany 
1
RTECS 
EX1260000
Autoignition Temperature
870 °F
TSCA 
Yes
HazardClass 
4.1
PackingGroup 
III
HS Code 
29142910
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H228Flammable solid

H315Causes skin irritation

H318Causes serious eye damage

H332Harmful if inhaled

H371May cause damage to organs

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
W223018
Product name
D-Camphor
Purity
≥97%, FG
Packaging
1kg
Price
$75.5
Updated
2024/03/01
Sigma-Aldrich
Product number
W223018
Product name
D-Camphor
Purity
≥97%, FG
Packaging
10Kg
Price
$513
Updated
2024/03/01
Sigma-Aldrich
Product number
50843
Product name
D-Camphor
Purity
analytical standard
Packaging
100mg
Price
$99.5
Updated
2024/03/01
Sigma-Aldrich
Product number
1087508
Product name
Camphor
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
1g
Price
$436
Updated
2024/03/01
Sigma-Aldrich
Product number
CRM40374
Product name
(1R)-(+)-Camphor solution
Purity
certified reference material, 2000?μg/mL in methanol, ampule of 1?mL
Packaging
1mL
Price
$109
Updated
2022/05/15
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D-CAMPHOR Chemical Properties,Usage,Production

Description

(1R)-(+)-Camphor is a terpene that has been found in C. sativa, C. indica, and C. sativa/C. indica hybrid strains as well as the essential oils from a variety of herbs including rosemary, lavender, and sage and has diverse biological activities. It inhibits norepinephrine secretion and cytosolic calcium and sodium increases induced by the nicotinic acetylcholine receptor (nAChR) agonist 1,1-dimethyl-4-phenylpiperazinium iodide (DMPP) in chromaffin cells (IC50s = 70, 88, and 19 μM, respectively). (1R)-(+)-Camphor (65-260 μM) induces proliferation of and increases expression of collagen IA, collagen IIIA, collagen IVA, and elastin in human primary dermal fibroblasts. In vivo, (1R)-(+)-camphor increases expression of collagen IA, collagen IIIA, collagen IVA, and elastin in skin in UV-exposed mice when administered at doses of 26 and 55 mM in drinking water post UV-exposure. It reduces cough frequency in citric acid-challenged guinea pigs. (1R)-(+)-Camphor is insecticidal, reducing digging activity and inducing mortality of fire ant workers. It has also been used as a building block in the synthesis of cannabinergic ligands.

Chemical Properties

white crystals

Chemical Properties

d-Camphor has a warm, minty, almost ethereal diffusive aroma. For other details of description, see Camphor Tree.

Occurrence

Frequently occurring in nature as the d- or l-form; the optically inactive form is seldom encountered. The d-form has been reported found in Cinnamomum camphora Ness. (Laurus camphora L.) from China, Japan and the East Indies; in Sassafras officinale, Lavandula spica and in other Labiatae. The l-form is reported found in the essential oils of Salvia grandiflora, Matricaria parthenium, Artemisia herba alba; the optically inactive form is found in Chrysanthemum japonicum sinense. Also reported found in orange peel oil, lemon peel oil, apricot, raspberry, anise, cinnamon root bark, ginger, pepper, coriander, calamus, sweet fennel and rosemary.

Uses

(1R)-(+)-Camphor is used as a chiral intermediate and auxiliary. It is also used as a skin antipruritic and as an anti-infective agent.

Uses

analgesic, antiinfective, antipruritic

Uses

D-Camphor may be used as reference material for the quantification of the analyte in Saraca asoca and coriander using chromatography techniques.

Uses

(R)-(+)-Camphor is a terpenoid with a wide variety of use. (R)-(+)-Camphor has insecticidal activity and is also used as an antimicrobial agent. (R)-(+)-Camphor is used as a culinary flavouring agent in parts of asia.

Definition

ChEBI: The (R)- enantiomer of camphor.

Aroma threshold values

Detection at 1 to 1.29 ppm

Taste threshold values

Taste characteristics at 20 ppm: medicinal, camphoraceous, mentholic and woody.

General Description

Colorless or white crystals. Sublimes. Flash point 149°F. Burns readily with a bright, smoky flame. Penetrating aromatic odor. Pungent, aromatic taste followed by a sensation of cold.

Air & Water Reactions

Flammable. Insoluble in water.

Reactivity Profile

D-CAMPHOR is incompatible with strong oxidizing agents, strong reducing agents and chlorinated solvents.

Fire Hazard

D-CAMPHOR is combustible.

Flammability and Explosibility

Flammable

Synthesis

Natural camphor is obtained by distillation from the plants of Cinnamomum or Laurus camphora from China and Japan, together with the corresponding essential oils; the raw camphor contains several impurities. It is separated from the water and the essential oil by pressure or by centrifugation and subsequently purified by sublimation or crystallization. Synthetic camphor is prepared from pinene isolated by fractional distillation of turpentine oil; pinene is reacted to bornyl chloride with gaseous HCl under pressure and then to camphene. The distilled and purified camphene is then oxidized to camphor with Na+ or K+ bichromate in the presence of H2SO4.

Purification Methods

Crystallise it from EtOH, 50% EtOH/water, MeOH, or pet ether or from glacial acetic acid by addition of water. It can be sublimed (50o/14mm) and also fractionally crystallised from its own melt. It is steam volatile. It should be stored in tight containers as it is appreciably volatile at room temperature. The solubility is 0.1% (H2O), 100% (EtOH), 173% (Et2O) and 300%

D-CAMPHOR Preparation Products And Raw materials

Raw materials

Preparation Products

EUROPIUM D-3-TRIFLUOROACETYLCAMPHORATE 3-TRIFLUOROACETYL-D-CAMPHOR Ambroxane (R)-(+)-BORNYLAMINE
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D-CAMPHOR Suppliers

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View Lastest Price from D-CAMPHOR manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Natural Camphor 464-49-3
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
99%
Supply Ability
500kg/month
Release date
2021-08-17
Hebei Fengjia New Material Co., Ltd
Product
D-CAMPHOR 464-49-3
Price
US $2.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10000
Release date
2024-09-02
Hebei Chuanghai Biotechnology Co., Ltd
Product
D-CAMPHOR 464-49-3
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 mt
Release date
2024-12-11

464-49-3, D-CAMPHORRelated Search:

methyl N,N,N-trimethyl-4-[(4,7,7-trimethyl-3-oxobicyclo[2.2.1]hept-2-ylidene)methyl]anilinium sulphate Dexketoprofen trometamol D(+)-Carvone Camphor tree, ext. TARCHONANTHUS CAMPHORATUS OIL TARCHONANTHUS CAMPHORATUS WATER PASSIFLORA LAURIFOLIA FLOWER EXTRACT PASSIFLORA LAURIFOLIA FRUIT EXTRACT EUROPIUM D-3-TRIFLUOROACETYLCAMPHORATE (1S)-(-)-3-Bromo Camphor, 98% min cis-O-Coumarinic acid lactoneCoumarinic acid lactone Tonka bean camphor (1S)-(+)-Camphor-10-sulphonic acid 3-(4-METHYLBENZYLIDENE)CAMPHOR  DL-CAMPHORIC ACID (1R)-(-)-THIOCAMPHOR EUROPIUM TRIS[3-(HEPTAFLUOROPROPYLHYDROXYMETHYLENE)-(+)-CAMPHORATE] White camphor oil (1s)-(+)-3-Bromo Camphor-10-Sulfonic Acid

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  • FEMA 2230
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  • Medical Level D-Camphor CAS 464-49-3 with Top Quality
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  • 464-49-3